| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMTK2 | lemur tyrosine kinase 2 | 0.0976805 |
| PRELID2 | PRELI domain containing 2 | 0.0861794 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0752199 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.075158 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.070039 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0688849 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0684694 |
| DST | dystonin | 0.0614775 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0605938 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0548373 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0513774 |
| CDC42SE2 | CDC42 small effector 2 | 0.048976 |
| ERBIN | erbb2 interacting protein | 0.0478896 |
| RNF213 | ring finger protein 213 | 0.0476844 |
| TUFT1 | tuftelin 1 | 0.045879 |
| GOLGA4 | golgin A4 | 0.0456665 |
| TRRAP | transformation/transcription domain-associated protein | 0.0448248 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.044785 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.044163 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.043199 |
| B2M | beta-2-microglobulin | 0.0415865 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0413544 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.041352 |
| KIF16B | kinesin family member 16B | 0.0390822 |
| FAM13A | family with sequence similarity 13, member A | 0.0390745 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0389861 |
| ZNF292 | zinc finger protein 292 | 0.0389139 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0379799 |
| TNS3 | tensin 3 | 0.0371678 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0370712 |
| MYOF | myoferlin | 0.0365092 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0360044 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0359506 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0355191 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0354916 |
| SQSTM1 | sequestosome 1 | 0.035353 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0348858 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0348798 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.034835 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0346456 |
| ADAR | adenosine deaminase, RNA-specific | 0.0345048 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0343479 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0336823 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.033202 |
| ANXA4 | annexin A4 | 0.0328909 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0321661 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0318744 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0316256 |
| MED13L | mediator complex subunit 13-like | 0.0313707 |
| PTK2 | protein tyrosine kinase 2 | 0.0310211 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.030611 |
| ITGAV | integrin, alpha V | 0.0305323 |
| CD2AP | CD2-associated protein | 0.030468 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0300936 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0299705 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0299152 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0298598 |
| KCNQ3 | potassium channel, voltage gated KQT-like subfamily Q, member 3 | 0.0292606 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0289337 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.028896 |
| ADM | adrenomedullin | 0.0288954 |
| PLAC8 | placenta-specific 8 | 0.0284234 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0281926 |
| PGK1 | phosphoglycerate kinase 1 | 0.0278734 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0278012 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0277269 |
| NPNT | nephronectin | 0.0273235 |
| FAT1 | FAT atypical cadherin 1 | 0.0269757 |
| APOL1 | apolipoprotein L, 1 | 0.0269746 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0265867 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.026313 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0262043 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0258426 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0257175 |
| DSPP | dentin sialophosphoprotein | 0.0255194 |
| TRIM31 | tripartite motif containing 31 | 0.0253949 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0253509 |
| PCM1 | pericentriolar material 1 | 0.025094 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0250623 |
| LIMA1 | LIM domain and actin binding 1 | 0.0249382 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0248752 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0247639 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0247274 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0245906 |
| ANLN | anillin, actin binding protein | 0.0245607 |
| AOPEP | aminopeptidase O (putative) | 0.0245246 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0245196 |
| ADD3 | adducin 3 (gamma) | 0.0244567 |
| MEF2A | myocyte enhancer factor 2A | 0.0244178 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0238384 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0237667 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0235054 |
| ETV6 | ets variant 6 | 0.0234006 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0233622 |
| ANXA11 | annexin A11 | 0.0229974 |
| GPD2 | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.0228332 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0220611 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.0212177 |
| KRT19 | keratin 19, type I | 0.0211951 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0211319 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.242221 |
| FLNB | filamin B, beta | -0.201288 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.174437 |
| LAMB3 | laminin, beta 3 | -0.154095 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.150355 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.148893 |
| EGFR | epidermal growth factor receptor | -0.126119 |
| VIM | vimentin | -0.114876 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.111198 |
| UBC | ubiquitin C | -0.111135 |
| NDRG1 | N-myc downstream regulated 1 | -0.105226 |
| EZR | ezrin | -0.102094 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0982116 |
| ASPH | aspartate beta-hydroxylase | -0.097992 |
| S100A10 | S100 calcium binding protein A10 | -0.0978696 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0877148 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.084646 |
| HMGA1 | high mobility group AT-hook 1 | -0.083762 |
| AHNAK | AHNAK nucleoprotein | -0.0787693 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0773433 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0747303 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0740088 |
| SDC4 | syndecan 4 | -0.0712079 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0709805 |
| LAMA4 | laminin, alpha 4 | -0.0670531 |
| POTEF | POTE ankyrin domain family, member F | -0.0649927 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0641206 |
| DOCK5 | dedicator of cytokinesis 5 | -0.063793 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0622545 |
| ITGA6 | integrin, alpha 6 | -0.0615844 |
| LMO7 | LIM domain 7 | -0.0613357 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0601908 |
| FAM107B | family with sequence similarity 107, member B | -0.0584643 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0575607 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.057182 |
| ACTG1 | actin gamma 1 | -0.0565347 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0559312 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0555813 |
| LAMC2 | laminin, gamma 2 | -0.0552772 |
| EGR1 | early growth response 1 | -0.0550542 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0549671 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0535434 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0534764 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0500962 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0492352 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0485671 |
| EMP1 | epithelial membrane protein 1 | -0.048179 |
| VCAN | versican | -0.0480233 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0479055 |
| MCL1 | myeloid cell leukemia 1 | -0.047875 |
| RUNX1 | runt-related transcription factor 1 | -0.0474661 |
| ANXA2 | annexin A2 | -0.0467709 |
| FOSL1 | FOS-like antigen 1 | -0.0467161 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0466284 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0439785 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0429247 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0429088 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0417937 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.041336 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0399183 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.039109 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0390037 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0389307 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0387521 |
| S100A11 | S100 calcium binding protein A11 | -0.0385182 |
| PARD3 | par-3 family cell polarity regulator | -0.0383602 |
| S100A6 | S100 calcium binding protein A6 | -0.0380909 |
| FAM3C | family with sequence similarity 3, member C | -0.0378166 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0376405 |
| RCOR1 | REST corepressor 1 | -0.0374091 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0373541 |
| HMGA2 | high mobility group AT-hook 2 | -0.0372063 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | -0.0371274 |
| FERMT1 | fermitin family member 1 | -0.0370091 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0369445 |
| PLEC | plectin | -0.0364327 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0363568 |
| CAPRIN2 | caprin family member 2 | -0.0363273 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.036288 |
| FBXO11 | F-box protein 11 | -0.0361371 |
| CALU | calumenin | -0.0357194 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.035512 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0354436 |
| PERP | PERP, TP53 apoptosis effector | -0.0354199 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0351553 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0351289 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0348035 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.034438 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0343229 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0339749 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0339297 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0338026 |
| DUSP6 | dual specificity phosphatase 6 | -0.033714 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0336511 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0332099 |
| KLF6 | Kruppel-like factor 6 | -0.0331816 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0327391 |
| IER3 | immediate early response 3 | -0.0319784 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0319706 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0315949 |
