| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.109148 |
| CEP250 | centrosomal protein 250kDa | 0.0941038 |
| TENM2 | teneurin transmembrane protein 2 | 0.0844127 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0834424 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0790249 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0690229 |
| DTNA | dystrobrevin, alpha | 0.0673723 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0654581 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0647023 |
| RAD51B | RAD51 paralog B | 0.054745 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0515922 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0499879 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0493925 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.049055 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0484299 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0447097 |
| PRLR | prolactin receptor | 0.041947 |
| DSPP | dentin sialophosphoprotein | 0.0403662 |
| ZNF292 | zinc finger protein 292 | 0.0399903 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0392628 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0379434 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0376546 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.037252 |
| EXOC4 | exocyst complex component 4 | 0.036918 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0366244 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0361663 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0357125 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0344519 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0333845 |
| PTMA | prothymosin, alpha | 0.0329635 |
| FNBP1L | formin binding protein 1-like | 0.0328991 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0328708 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0324942 |
| FOXN3 | forkhead box N3 | 0.0322995 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0319464 |
| ENAH | enabled homolog (Drosophila) | 0.0315447 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0309099 |
| GSDMB | gasdermin B | 0.0306974 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0301388 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0297825 |
| BBX | bobby sox homolog (Drosophila) | 0.0288274 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0287334 |
| NEBL | nebulette | 0.0284975 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0283743 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0283504 |
| MSI2 | musashi RNA-binding protein 2 | 0.0281676 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0280137 |
| PRELID2 | PRELI domain containing 2 | 0.0279786 |
| AUTS2 | autism susceptibility candidate 2 | 0.0266708 |
| SEPTIN11 | septin 11 | 0.0264048 |
| CLTC | clathrin, heavy chain (Hc) | 0.0263801 |
| PGM2L1 | phosphoglucomutase 2-like 1 | 0.026071 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0260165 |
| TMEM123 | transmembrane protein 123 | 0.025867 |
| GSE1 | Gse1 coiled-coil protein | 0.0258262 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0258058 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0256045 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0255199 |
| ZFHX3 | zinc finger homeobox 3 | 0.0253719 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0252385 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.0249372 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0248654 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0248566 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0248427 |
| TPD52 | tumor protein D52 | 0.0247997 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | 0.0247714 |
| MACROD2 | MACRO domain containing 2 | 0.024663 |
| DENND1A | DENN/MADD domain containing 1A | 0.0246061 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0246037 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0240248 |
| ESRRG | estrogen-related receptor gamma | 0.0239904 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.023631 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0234173 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | 0.0234142 |
| CANX | calnexin | 0.0232359 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | 0.0231567 |
| FOXO3 | forkhead box O3 | 0.023091 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0230026 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0229903 |
| CCNY | cyclin Y | 0.0229403 |
| FAM168A | family with sequence similarity 168, member A | 0.0227314 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0226455 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0225177 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0223125 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.022127 |
| MYO10 | myosin X | 0.0221257 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0221169 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0220968 |
| HELZ | helicase with zinc finger | 0.0218942 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0218783 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0218494 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.0215005 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0214493 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0213085 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.02129 |
| NDRG1 | N-myc downstream regulated 1 | 0.0210906 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0210541 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | 0.0209712 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0209115 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0208437 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.126693 |
| ASPH | aspartate beta-hydroxylase | -0.108038 |
| RPL23 | ribosomal protein L23 | -0.107201 |
| RPL19 | ribosomal protein L19 | -0.103515 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0950857 |
| ANKRD36C | ankyrin repeat domain 36C | -0.090464 |
| SMYD3 | SET and MYND domain containing 3 | -0.0813002 |
| NTN4 | netrin 4 | -0.0754511 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0748524 |
| CCND1 | cyclin D1 | -0.0742094 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0734721 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.0708564 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0670604 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0659484 |
| RAB22A | RAB22A, member RAS oncogene family | -0.064629 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0629834 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0625803 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0620484 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0615254 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0603955 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0600924 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0536356 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0533194 |
| DOCK5 | dedicator of cytokinesis 5 | -0.052645 |
| MT2A | metallothionein 2A | -0.0511052 |
| TMSB10 | thymosin beta 10 | -0.0483675 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0472576 |
| S100A9 | S100 calcium binding protein A9 | -0.0467128 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0453253 |
| EGR1 | early growth response 1 | -0.0441447 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0435551 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0433451 |
| TMEM45B | transmembrane protein 45B | -0.0424635 |
| GLCCI1 | glucocorticoid induced 1 | -0.0422859 |
| VMP1 | vacuole membrane protein 1 | -0.0420814 |
| S100A14 | S100 calcium binding protein A14 | -0.0414788 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0408482 |
| S100A8 | S100 calcium binding protein A8 | -0.0408056 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0403263 |
| OSMR | oncostatin M receptor | -0.0386023 |
| ANXA2 | annexin A2 | -0.0380205 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0377399 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0364165 |
| ACTG1 | actin gamma 1 | -0.0364092 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0355392 |
| AREG | amphiregulin | -0.0349322 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0345296 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0341745 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0341326 |
| SYTL2 | synaptotagmin-like 2 | -0.0331028 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0328343 |
| AHR | aryl hydrocarbon receptor | -0.0328177 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.032318 |
| DUSP4 | dual specificity phosphatase 4 | -0.0318799 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0316768 |
| TMEM165 | transmembrane protein 165 | -0.0311848 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0311796 |
| POTEF | POTE ankyrin domain family, member F | -0.0309714 |
| ITGB6 | integrin, beta 6 | -0.0301985 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0293713 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0284072 |
| SPTSSB | serine palmitoyltransferase, small subunit B | -0.0283395 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0280629 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0277213 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0275908 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0268631 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0265788 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0265055 |
| S100A6 | S100 calcium binding protein A6 | -0.0263761 |
| TXNRD1 | thioredoxin reductase 1 | -0.0259002 |
| GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | -0.0252452 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0252015 |
| INSR | insulin receptor | -0.0248561 |
| RESF1 | retroelement silencing factor 1 | -0.0248529 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0248054 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0247672 |
| UBAP1 | ubiquitin associated protein 1 | -0.0246283 |
| ABHD17C | abhydrolase domain containing 17C | -0.0246067 |
| MYOF | myoferlin | -0.0240313 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0237456 |
| SMAD3 | SMAD family member 3 | -0.0236481 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0236034 |
| SDC4 | syndecan 4 | -0.0234893 |
| SMIM14 | small integral membrane protein 14 | -0.0232034 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0230896 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0227597 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0226008 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0224421 |
| KRT7 | keratin 7, type II | -0.0223095 |
| MAP7 | microtubule-associated protein 7 | -0.0222332 |
| RAI14 | retinoic acid induced 14 | -0.0221521 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0220073 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0220009 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0217781 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0217096 |
| RPL35A | ribosomal protein L35a | -0.0216028 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0214719 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0212364 |
| CD63 | CD63 molecule | -0.0209552 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0204291 |
