| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL5A2 | collagen, type V, alpha 2 | 0.155719 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.133775 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.118859 |
| TOX | thymocyte selection-associated high mobility group box | 0.118191 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.101898 |
| CDH18 | cadherin 18, type 2 | 0.0789884 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0766226 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0702668 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 0.0698489 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0571453 |
| RAD51B | RAD51 paralog B | 0.0553354 |
| CADM2 | cell adhesion molecule 2 | 0.0496236 |
| DST | dystonin | 0.0479799 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | 0.0473689 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0424306 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.04236 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0396759 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0385719 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0380702 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0373545 |
| CABIN1 | calcineurin binding protein 1 | 0.0369776 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0357028 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0351821 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0332096 |
| EFNA5 | ephrin-A5 | 0.0329709 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | 0.0324623 |
| ZNF292 | zinc finger protein 292 | 0.0311216 |
| PRELID2 | PRELI domain containing 2 | 0.0309528 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0308522 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0286792 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0277745 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0270797 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0261645 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0253703 |
| MED13L | mediator complex subunit 13-like | 0.0251624 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0232835 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0231674 |
| ATRN | attractin | 0.0230472 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0225322 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0224018 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0222651 |
| SERTAD2 | SERTA domain containing 2 | 0.0221097 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0217251 |
| CALR | calreticulin | 0.021674 |
| JMJD1C | jumonji domain containing 1C | 0.0216398 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0215825 |
| FHIT | fragile histidine triad | 0.0214544 |
| ANK2 | ankyrin 2, neuronal | 0.0204537 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0202476 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0196537 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0194544 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0190042 |
| CDK19 | cyclin-dependent kinase 19 | 0.0188724 |
| ASPH | aspartate beta-hydroxylase | 0.0186637 |
| JUN | jun proto-oncogene | 0.0186372 |
| RPL9 | ribosomal protein L9 | 0.0183673 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0181328 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0180523 |
| ADAR | adenosine deaminase, RNA-specific | 0.0180085 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0179427 |
| PDE8A | phosphodiesterase 8A | 0.017834 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0178318 |
| BNC2 | basonuclin 2 | 0.0178146 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0176979 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0176803 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.0174096 |
| ATG10 | autophagy related 10 | 0.0169672 |
| RNF150 | ring finger protein 150 | 0.016884 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0168268 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0166497 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0166132 |
| PHF21A | PHD finger protein 21A | 0.0166037 |
| SMAD4 | SMAD family member 4 | 0.0165379 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0163242 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0161795 |
| HELZ | helicase with zinc finger | 0.0159729 |
| CEP250 | centrosomal protein 250kDa | 0.0159584 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0159309 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0159069 |
| NRG1 | neuregulin 1 | 0.0157212 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.015715 |
| INSIG2 | insulin induced gene 2 | 0.0155836 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0155564 |
| ANXA2 | annexin A2 | 0.0155428 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0155126 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0154516 |
| RTN4 | reticulon 4 | 0.0154259 |
| GAB2 | GRB2-associated binding protein 2 | 0.0153701 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.015127 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0149604 |
| COG6 | component of oligomeric golgi complex 6 | 0.0148937 |
| B2M | beta-2-microglobulin | 0.0146898 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0145891 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0144375 |
| FOSL2 | FOS-like antigen 2 | 0.0143063 |
| IGF2 | insulin-like growth factor 2 | 0.0140465 |
| RPL21 | ribosomal protein L21 | 0.0140104 |
| ARRDC3 | arrestin domain containing 3 | 0.0140051 |
| MLIP | muscular LMNA-interacting protein | 0.0138414 |
| PCBP2 | poly(rC) binding protein 2 | 0.0138303 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.098204 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0640421 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0620196 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0578685 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0569784 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0551973 |
| ACTG1 | actin gamma 1 | -0.0524108 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.051763 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0481039 |
| RPS6 | ribosomal protein S6 | -0.047453 |
| EGR1 | early growth response 1 | -0.0457382 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.045415 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0451244 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0437339 |
| NEBL | nebulette | -0.043543 |
| PTMA | prothymosin, alpha | -0.0433328 |
| NF1 | neurofibromin 1 | -0.0433116 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0424352 |
| HHIP | hedgehog interacting protein | -0.0412691 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0404642 |
| RPS24 | ribosomal protein S24 | -0.0392989 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0387145 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0378129 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0368928 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0367821 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0366963 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0365777 |
| LDHA | lactate dehydrogenase A | -0.0365353 |
| ATP11A | ATPase, class VI, type 11A | -0.0362961 |
| GNAS | GNAS complex locus | -0.0356814 |
| DEK | DEK proto-oncogene | -0.0348998 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.034143 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0327432 |
| RPL28 | ribosomal protein L28 | -0.0326835 |
| RPLP1 | ribosomal protein, large, P1 | -0.0324947 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0315278 |
| RPL26 | ribosomal protein L26 | -0.0302934 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0297702 |
| RPL32 | ribosomal protein L32 | -0.0292419 |
| RPL12 | ribosomal protein L12 | -0.029224 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0291732 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0291 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0290483 |
| MKI67 | marker of proliferation Ki-67 | -0.0287458 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0287314 |
| IPO7 | importin 7 | -0.02831 |
| ENAH | enabled homolog (Drosophila) | -0.0278927 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0271247 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.027069 |
| RPL4 | ribosomal protein L4 | -0.0269573 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0265993 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0264741 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0262747 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0261736 |
| MATR3 | matrin 3 | -0.0260575 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0258353 |
| RPS4X | ribosomal protein S4, X-linked | -0.0256151 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0255061 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0254263 |
| RPS21 | ribosomal protein S21 | -0.0254098 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0247817 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0247375 |
| RPLP0 | ribosomal protein, large, P0 | -0.0247029 |
| MDN1 | MDN1, midasin homolog (yeast) | -0.0246213 |
| ZNF217 | zinc finger protein 217 | -0.0244668 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.0243716 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0243469 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | -0.0242921 |
| TUBB | tubulin, beta class I | -0.0242039 |
| RBM28 | RNA binding motif protein 28 | -0.0241795 |
| TPD52 | tumor protein D52 | -0.0240834 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0240121 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0239624 |
| RPL11 | ribosomal protein L11 | -0.02356 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0233828 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0230192 |
| ABI2 | abl-interactor 2 | -0.023007 |
| HMGB1 | high mobility group box 1 | -0.0228579 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0222983 |
| TMSB10 | thymosin beta 10 | -0.0221599 |
| TMEM123 | transmembrane protein 123 | -0.0221339 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0219468 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0219447 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0219258 |
| NOP58 | NOP58 ribonucleoprotein | -0.0218985 |
| PFN1 | profilin 1 | -0.0218404 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0216496 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0215256 |
| WLS | wntless Wnt ligand secretion mediator | -0.0213938 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0213584 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0213524 |
| RACK1 | receptor for activated C kinase 1 | -0.0211302 |
| HMGA1 | high mobility group AT-hook 1 | -0.0209063 |
| HSPA8 | heat shock 70kDa protein 8 | -0.020897 |
| RPL34 | ribosomal protein L34 | -0.0208833 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0208809 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0208626 |
| CBX3 | chromobox homolog 3 | -0.0208556 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0208527 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0206428 |
