Trametinib (DMSO_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib (DMSO perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib (DMSO_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD109 CD109 molecule 0.0998543
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.092536
TRIM2 tripartite motif containing 2 0.0901972
NAV2 neuron navigator 2 0.0761436
PRKD1 protein kinase D1 0.0616705
NAV3 neuron navigator 3 0.0596781
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.053465
ZEB2 zinc finger E-box binding homeobox 2 0.0520411
NAMPT nicotinamide phosphoribosyltransferase 0.0458187
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0425248
KIF13A kinesin family member 13A 0.0403932
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0358609
APP amyloid beta (A4) precursor protein 0.0356636
DST dystonin 0.0354511
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0351311
RUNX1 runt-related transcription factor 1 0.0350263
RNF150 ring finger protein 150 0.0339457
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0320551
CD44 CD44 molecule (Indian blood group) 0.031978
AKAP9 A kinase (PRKA) anchor protein 9 0.0308181
SOX6 SRY (sex determining region Y)-box 6 0.0305111
GBP2 guanylate binding protein 2, interferon-inducible 0.0298634
DCT dopachrome tautomerase 0.0297252
DMD dystrophin 0.0296905
GRID1 glutamate receptor, ionotropic, delta 1 0.0290935
ANXA2 annexin A2 0.0290935
ESYT2 extended synaptotagmin-like protein 2 0.0290687
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0290328
MRTFA myocardin related transcription factor A 0.0290126
KDM3A lysine (K)-specific demethylase 3A 0.0289688
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0271205
TJP2 tight junction protein 2 0.0264455
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0264289
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0262754
QKI QKI, KH domain containing, RNA binding 0.0261109
SSH2 slingshot protein phosphatase 2 0.0257993
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0254854
ARHGAP24 Rho GTPase activating protein 24 0.025266
TENT5A terminal nucleotidyltransferase 5A 0.0251072
UTRN utrophin 0.0250251
ZNF608 zinc finger protein 608 0.0250105
MED13L mediator complex subunit 13-like 0.0248729
ZBTB20 zinc finger and BTB domain containing 20 0.0243022
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0240512
FBXL7 F-box and leucine-rich repeat protein 7 0.0237914
RHOBTB3 Rho-related BTB domain containing 3 0.0236333
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.0227051
FBXO7 F-box protein 7 0.0223129
TMEM123 transmembrane protein 123 0.0221541
SOD2 superoxide dismutase 2, mitochondrial 0.0219066
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0217833
WDFY1 WD repeat and FYVE domain containing 1 0.0213903
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0213289
RAD21 RAD21 homolog (S. pombe) 0.0212122
OGA O-GlcNAcase 0.021136
CDK19 cyclin-dependent kinase 19 0.0209205
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0208099
TNRC6A trinucleotide repeat containing 6A 0.0204568
PDZRN3 PDZ domain containing ring finger 3 0.0197836
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0196614
HMGB2 high mobility group box 2 0.0194618
CAMTA1 calmodulin binding transcription activator 1 0.0193037
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0189659
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 0.0189234
IFI16 interferon, gamma-inducible protein 16 0.0186945
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.018685
MCC mutated in colorectal cancers 0.0185062
C1ORF21 chromosome 1 open reading frame 21 0.0183809
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0182854
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0180971
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0179415
RBM33 RNA binding motif protein 33 0.0179386
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0177831
LDHD lactate dehydrogenase D 0.0177139
HIPK2 homeodomain interacting protein kinase 2 0.0176553
AUTS2 autism susceptibility candidate 2 0.0175497
NRG1 neuregulin 1 0.0175461
ZBTB10 zinc finger and BTB domain containing 10 0.0172418
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.017211
MKI67 marker of proliferation Ki-67 0.0171324
WDR43 WD repeat domain 43 0.0168812
COL5A2 collagen, type V, alpha 2 0.0167985
SORBS2 sorbin and SH3 domain containing 2 0.0167118
MEF2C myocyte enhancer factor 2C 0.016638
KDM6A lysine (K)-specific demethylase 6A 0.016633
STXBP1 syntaxin binding protein 1 0.0163914
SESN3 sestrin 3 0.0163816
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0162371
TKT transketolase 0.0162076
NCOR2 nuclear receptor corepressor 2 0.0161889
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0158866
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0157863
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0156959
GPHN gephyrin 0.0156303
FUBP1 far upstream element (FUSE) binding protein 1 0.0155485
MSI2 musashi RNA-binding protein 2 0.0154456
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0152486
LCORL ligand dependent nuclear receptor corepressor-like 0.015204
CENPE centromere protein E, 312kDa 0.015186
ZNF654 zinc finger protein 654 0.0150729

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.266891
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.262383
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.197076
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.132354
IGFBP3 insulin-like growth factor binding protein 3 -0.120179
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.105718
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0913943
VGF VGF nerve growth factor inducible -0.0913403
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0837047
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0818301
NLGN1 neuroligin 1 -0.0813795
EGR1 early growth response 1 -0.0748875
NPAS2 neuronal PAS domain protein 2 -0.0714464
AKAP12 A kinase (PRKA) anchor protein 12 -0.0670354
MT2A metallothionein 2A -0.0647775
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0647324
IGFBP5 insulin-like growth factor binding protein 5 -0.0631266
FRMD4A FERM domain containing 4A -0.0609323
NPC1 Niemann-Pick disease, type C1 -0.056349
MAML3 mastermind-like 3 (Drosophila) -0.0555892
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0549333
NHSL1 NHS-like 1 -0.05373
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.053209
COL19A1 collagen, type XIX, alpha 1 -0.0531742
PTK2 protein tyrosine kinase 2 -0.0526197
NDRG1 N-myc downstream regulated 1 -0.0503554
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0494453
TNNC1 troponin C type 1 (slow) -0.0482453
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0480739
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0479896
IL1RAP interleukin 1 receptor accessory protein -0.0479546
PARVB parvin, beta -0.0473728
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0471642
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0470557
TMSB10 thymosin beta 10 -0.0469318
MACROD2 MACRO domain containing 2 -0.0461422
CDK14 cyclin-dependent kinase 14 -0.0458416
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0457403
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0446751
PDIA4 protein disulfide isomerase family A, member 4 -0.0444888
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0435194
LEF1 lymphoid enhancer-binding factor 1 -0.0434274
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0431973
RNF145 ring finger protein 145 -0.0425036
S100A6 S100 calcium binding protein A6 -0.0422174
CHSY1 chondroitin sulfate synthase 1 -0.0421265
PRELID2 PRELI domain containing 2 -0.042001
ACTN1 actinin, alpha 1 -0.041678
IGF1R insulin-like growth factor 1 receptor -0.0410895
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.04107
VIM vimentin -0.0409126
LOC112694756 uncharaterized LOC112694756 -0.0399746
CLMN calmin (calponin-like, transmembrane) -0.0399479
FMN1 formin 1 -0.0395988
GPC6 glypican 6 -0.0393383
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -0.0390907
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0387299
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0384026
TAC4 tachykinin 4 (hemokinin) -0.037861
PKM pyruvate kinase, muscle -0.0378354
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0378294
FMNL2 formin-like 2 -0.0377879
PTPRG protein tyrosine phosphatase, receptor type, G -0.0375921
TBC1D22A TBC1 domain family, member 22A -0.0370638
SDC2 syndecan 2 -0.0370184
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0370052
TMEM178B transmembrane protein 178B -0.0369839
MCTP1 multiple C2 domains, transmembrane 1 -0.0360429
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0357087
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0355384
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0353203
FOSL1 FOS-like antigen 1 -0.0352962
GDF15 growth differentiation factor 15 -0.0344213
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0343455
MEF2A myocyte enhancer factor 2A -0.0341357
WWTR1 WW domain containing transcription regulator 1 -0.0340435
PDIA3 protein disulfide isomerase family A, member 3 -0.0339329
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0336947
FTL ferritin, light polypeptide -0.0334618
MCL1 myeloid cell leukemia 1 -0.0332304
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0326448
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0326322
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0325491
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0320128
BACE2 beta-site APP-cleaving enzyme 2 -0.0317972
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0316573
DOCK4 dedicator of cytokinesis 4 -0.0309736
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0306751
MYO10 myosin X -0.0306361
TLE4 transducin-like enhancer of split 4 -0.0305133
GLS2 glutaminase 2 (liver, mitochondrial) -0.0304663
EHBP1 EH domain binding protein 1 -0.0303804
SEC24A SEC24 family member A -0.0303461
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0303309
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0302086
CSNK1E casein kinase 1, epsilon -0.030086
RYBP RING1 and YY1 binding protein -0.0285309
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0280172
SAMD4A sterile alpha motif domain containing 4A -0.0278792
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.027844