| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.181878 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.122023 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0792279 |
| RNF213 | ring finger protein 213 | 0.0778458 |
| FAM13A | family with sequence similarity 13, member A | 0.0765339 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0752541 |
| APOL1 | apolipoprotein L, 1 | 0.0743531 |
| APOL2 | apolipoprotein L, 2 | 0.0696529 |
| CD47 | CD47 molecule | 0.0669049 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0664427 |
| CFB | complement factor B | 0.0619565 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.061012 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.0605444 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0579571 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0548444 |
| ARRDC3 | arrestin domain containing 3 | 0.0536075 |
| MX1 | MX dynamin-like GTPase 1 | 0.053517 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0524021 |
| MYOF | myoferlin | 0.0505806 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.050427 |
| CP | ceruloplasmin (ferroxidase) | 0.0501705 |
| TSC22D2 | TSC22 domain family, member 2 | 0.04887 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.044244 |
| B2M | beta-2-microglobulin | 0.0428447 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0426192 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0423106 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0422047 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0421874 |
| MUC4 | mucin 4, cell surface associated | 0.0420587 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0417001 |
| FGB | fibrinogen beta chain | 0.0415337 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0415095 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0411911 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0405577 |
| ADM | adrenomedullin | 0.0395655 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0393342 |
| PCBP2 | poly(rC) binding protein 2 | 0.039175 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0389934 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0384484 |
| PROM1 | prominin 1 | 0.0374802 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0370923 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0369399 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0365755 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0364179 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.036406 |
| ENO1 | enolase 1, (alpha) | 0.0359306 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0348802 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0345686 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0344125 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0339471 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0338205 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.033593 |
| ANXA4 | annexin A4 | 0.0333317 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0332445 |
| CCNY | cyclin Y | 0.0331362 |
| HELZ | helicase with zinc finger | 0.0329484 |
| TFG | TRK-fused gene | 0.0327024 |
| TMEM123 | transmembrane protein 123 | 0.0326072 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.032321 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.032232 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0322149 |
| ADAR | adenosine deaminase, RNA-specific | 0.0321472 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0320118 |
| TXNIP | thioredoxin interacting protein | 0.0317032 |
| PDGFC | platelet derived growth factor C | 0.0313547 |
| PDZD8 | PDZ domain containing 8 | 0.0311679 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0311271 |
| GBP4 | guanylate binding protein 4 | 0.0306745 |
| CALR | calreticulin | 0.0300936 |
| WWC1 | WW and C2 domain containing 1 | 0.0295765 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0291345 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.028746 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0280501 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0279645 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0274778 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0273341 |
| STC2 | stanniocalcin 2 | 0.0269033 |
| KYNU | kynureninase | 0.0267281 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0266721 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0264598 |
| DAPK1 | death-associated protein kinase 1 | 0.0262664 |
| OPTN | optineurin | 0.026204 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0261652 |
| BRD2 | bromodomain containing 2 | 0.0257967 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0257781 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.025565 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0255399 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0254428 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0252532 |
| TXNRD1 | thioredoxin reductase 1 | 0.0246652 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.024403 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0242741 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.024224 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0240169 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0238682 |
| BBX | bobby sox homolog (Drosophila) | 0.0238081 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0237838 |
| YTHDC1 | YTH domain containing 1 | 0.0235712 |
| APOL6 | apolipoprotein L, 6 | 0.023245 |
| MUC16 | mucin 16, cell surface associated | 0.0232286 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.205396 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.164834 |
| LAMB3 | laminin, beta 3 | -0.129643 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.128753 |
| MT2A | metallothionein 2A | -0.121988 |
| EFNA5 | ephrin-A5 | -0.1135 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.110498 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.105303 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.100925 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.10021 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0924938 |
| LAMC2 | laminin, gamma 2 | -0.0876248 |
| ASPH | aspartate beta-hydroxylase | -0.0869854 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0788058 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0757188 |
| LAMA4 | laminin, alpha 4 | -0.0730012 |
| ACTG1 | actin gamma 1 | -0.0729366 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0686273 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0676515 |
| ITGA6 | integrin, alpha 6 | -0.0632659 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0624528 |
| PARD3 | par-3 family cell polarity regulator | -0.0623869 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0612872 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0612817 |
| TOP1 | topoisomerase (DNA) I | -0.0607455 |
| TMSB4X | thymosin beta 4, X-linked | -0.0572859 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0552556 |
| NDRG1 | N-myc downstream regulated 1 | -0.0548302 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0543209 |
| HMGA1 | high mobility group AT-hook 1 | -0.0519227 |
| RTN4 | reticulon 4 | -0.0514346 |
| BCL2L1 | BCL2-like 1 | -0.0512296 |
| FAM3C | family with sequence similarity 3, member C | -0.0511911 |
| S100A6 | S100 calcium binding protein A6 | -0.0499265 |
| CDCP1 | CUB domain containing protein 1 | -0.0493676 |
| EGR1 | early growth response 1 | -0.0490486 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0484539 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0480923 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0470331 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0468381 |
| VIM | vimentin | -0.0464385 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0462005 |
| FLNB | filamin B, beta | -0.0460858 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0459622 |
| HPCAL1 | hippocalcin-like 1 | -0.0459337 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0458074 |
| ANTXR2 | anthrax toxin receptor 2 | -0.045403 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0449083 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0437145 |
| KRT19 | keratin 19, type I | -0.0434077 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0422204 |
| RPLP1 | ribosomal protein, large, P1 | -0.0421529 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0421223 |
| HMGA2 | high mobility group AT-hook 2 | -0.0415349 |
| LMO7 | LIM domain 7 | -0.0412212 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0410674 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0408581 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0406882 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.040682 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0402154 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0401594 |
| MCL1 | myeloid cell leukemia 1 | -0.0400132 |
| SMYD3 | SET and MYND domain containing 3 | -0.0399277 |
| S100A10 | S100 calcium binding protein A10 | -0.0397852 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0397077 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0395895 |
| NPAS2 | neuronal PAS domain protein 2 | -0.039373 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0379232 |
| KIF13B | kinesin family member 13B | -0.0378938 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0375206 |
| MYO1E | myosin IE | -0.0374877 |
| TPM4 | tropomyosin 4 | -0.0373009 |
| AHNAK | AHNAK nucleoprotein | -0.0369539 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0368182 |
| HLA-B | major histocompatibility complex, class I, B | -0.0365214 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0362188 |
| ITGA1 | integrin, alpha 1 | -0.036119 |
| VCL | vinculin | -0.0359514 |
| POTEF | POTE ankyrin domain family, member F | -0.0355336 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0355119 |
| NRP1 | neuropilin 1 | -0.0354641 |
| RASA2 | RAS p21 protein activator 2 | -0.0354588 |
| PRKCA | protein kinase C, alpha | -0.0353549 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.035166 |
| EZR | ezrin | -0.034736 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0346445 |
| AREG | amphiregulin | -0.0345231 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0341737 |
| ACTN1 | actinin, alpha 1 | -0.0340724 |
| PLAU | plasminogen activator, urokinase | -0.0336979 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0333295 |
| ANXA2 | annexin A2 | -0.0332579 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0329963 |
| OSMR | oncostatin M receptor | -0.032827 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0324465 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0324358 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0322566 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0321769 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0320327 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0319936 |
