| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.157078 |
| PTMA | prothymosin, alpha | 0.118465 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.107256 |
| VIM | vimentin | 0.106577 |
| AHNAK | AHNAK nucleoprotein | 0.103103 |
| COL1A1 | collagen, type I, alpha 1 | 0.0988887 |
| DST | dystonin | 0.0878693 |
| ANXA2 | annexin A2 | 0.0851012 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0804044 |
| LMNA | lamin A/C | 0.0802402 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0800792 |
| COL3A1 | collagen, type III, alpha 1 | 0.079065 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0788262 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0778757 |
| MAP1B | microtubule-associated protein 1B | 0.0766335 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0745746 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0729569 |
| HMGB2 | high mobility group box 2 | 0.0682133 |
| LPIN1 | lipin 1 | 0.0678543 |
| HELZ | helicase with zinc finger | 0.0594298 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0585043 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0553135 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0543453 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0525414 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0511221 |
| CANX | calnexin | 0.0497047 |
| PCDH9 | protocadherin 9 | 0.0490913 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.048518 |
| RPL19 | ribosomal protein L19 | 0.0481686 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.047935 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0473988 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0468852 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0466628 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0462065 |
| MAP4 | microtubule-associated protein 4 | 0.0455048 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0449824 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0443866 |
| SYT1 | synaptotagmin I | 0.0441281 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0436919 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0434198 |
| SPAG9 | sperm associated antigen 9 | 0.0431073 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0426837 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0426276 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0424517 |
| ACTG1 | actin gamma 1 | 0.0414071 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0404664 |
| TLK2 | tousled-like kinase 2 | 0.0402782 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0401106 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0400902 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0393933 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0391165 |
| SQSTM1 | sequestosome 1 | 0.0384575 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0383994 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0382929 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0381821 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0381494 |
| XPO1 | exportin 1 | 0.0380326 |
| CENPF | centromere protein F, 350/400kDa | 0.0377095 |
| SETD5 | SET domain containing 5 | 0.0375829 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0374086 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0365389 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0359655 |
| PTK2 | protein tyrosine kinase 2 | 0.0357592 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0356907 |
| ZNF804A | zinc finger protein 804A | 0.0353856 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0351113 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0350449 |
| RPL37A | ribosomal protein L37a | 0.0349552 |
| TPR | translocated promoter region, nuclear basket protein | 0.0349081 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0345962 |
| OGA | O-GlcNAcase | 0.0345409 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0341981 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0339639 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0339128 |
| RBM39 | RNA binding motif protein 39 | 0.0338642 |
| TOX | thymocyte selection-associated high mobility group box | 0.0334877 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0329959 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0328948 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0324548 |
| CCNY | cyclin Y | 0.0324377 |
| USP3 | ubiquitin specific peptidase 3 | 0.0320748 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0310824 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.03098 |
| SRP72 | signal recognition particle 72kDa | 0.0305428 |
| QKI | QKI, KH domain containing, RNA binding | 0.0302274 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0300585 |
| CCND1 | cyclin D1 | 0.0299561 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.029608 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0295694 |
| OTUD7B | OTU deubiquitinase 7B | 0.0290993 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.029098 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0290558 |
| RIOK3 | RIO kinase 3 | 0.029002 |
| RPL12 | ribosomal protein L12 | 0.0288751 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0288317 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0286984 |
| S100A6 | S100 calcium binding protein A6 | 0.0283979 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0282755 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0282293 |
| KIF5B | kinesin family member 5B | 0.0281109 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.329809 |
| LSAMP | limbic system-associated membrane protein | -0.109902 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.101915 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.100813 |
| DPH6 | diphthamine biosynthesis 6 | -0.0923153 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0863917 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0827218 |
| KLHL13 | kelch-like family member 13 | -0.0652186 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0639853 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0625162 |
| NRG1 | neuregulin 1 | -0.0582469 |
| PRKCA | protein kinase C, alpha | -0.0521162 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0465508 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | -0.0452966 |
| ANTXR1 | anthrax toxin receptor 1 | -0.044684 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0435429 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0424803 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0421281 |
| FNDC3B | fibronectin type III domain containing 3B | -0.042037 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0414481 |
| PLAT | plasminogen activator, tissue | -0.04068 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.039867 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0398593 |
| SIK2 | salt-inducible kinase 2 | -0.0387004 |
| PTEN | phosphatase and tensin homolog | -0.037078 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0358629 |
| VCL | vinculin | -0.035835 |
| GNG2 | guanine nucleotide binding protein (G protein), gamma 2 | -0.0354613 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | -0.0344367 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0334752 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0325859 |
| TENM4 | teneurin transmembrane protein 4 | -0.0312535 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0312484 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0312187 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0311296 |
| GAB2 | GRB2-associated binding protein 2 | -0.0311262 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0306347 |
| EFNA5 | ephrin-A5 | -0.0303447 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0301811 |
| SMYD3 | SET and MYND domain containing 3 | -0.0300141 |
| GPC5 | glypican 5 | -0.0299944 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0299147 |
| ANGPT1 | angiopoietin 1 | -0.0295965 |
| EGR1 | early growth response 1 | -0.0293538 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0291917 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0286778 |
| BBX | bobby sox homolog (Drosophila) | -0.0277144 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0277002 |
| NF1 | neurofibromin 1 | -0.0275035 |
| BPTF | bromodomain PHD finger transcription factor | -0.0273143 |
| HMGA2 | high mobility group AT-hook 2 | -0.027203 |
| ARHGAP9 | Rho GTPase activating protein 9 | -0.0266039 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0251292 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0251188 |
| TBX2 | T-box 2 | -0.0248085 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0247763 |
| PDE10A | phosphodiesterase 10A | -0.0247637 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0245081 |
| VMP1 | vacuole membrane protein 1 | -0.0245014 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.0242569 |
| GPC6 | glypican 6 | -0.024003 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0237856 |
| NCOR2 | nuclear receptor corepressor 2 | -0.023642 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0235434 |
| NRP1 | neuropilin 1 | -0.0232246 |
| STK38L | serine/threonine kinase 38 like | -0.0229057 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | -0.0227738 |
| GLCCI1 | glucocorticoid induced 1 | -0.0219486 |
| AMOTL1 | angiomotin like 1 | -0.0214423 |
| GLI3 | GLI family zinc finger 3 | -0.0211431 |
| MEF2D | myocyte enhancer factor 2D | -0.0211235 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0207674 |
| ETV1 | ets variant 1 | -0.0204349 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0203615 |
| DNM3 | dynamin 3 | -0.0203087 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0202746 |
| VEGFA | vascular endothelial growth factor A | -0.0200665 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0200174 |
| MSI2 | musashi RNA-binding protein 2 | -0.0198558 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.019731 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0190602 |
| SSH1 | slingshot protein phosphatase 1 | -0.0190041 |
| SKIL | SKI-like proto-oncogene | -0.01898 |
| ATXN10 | ataxin 10 | -0.0189344 |
| RET | ret proto-oncogene | -0.0187582 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0187262 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0187237 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0186667 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0186398 |
| POTEF | POTE ankyrin domain family, member F | -0.0185455 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0185359 |
| LONRF2 | LON peptidase N-terminal domain and ring finger 2 | -0.0184628 |
| FMN1 | formin 1 | -0.0180117 |
| HAS2 | hyaluronan synthase 2 | -0.0179625 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0177339 |
| APPBP2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | -0.017694 |
| SH3PXD2B | SH3 and PX domains 2B | -0.017282 |
| EDNRA | endothelin receptor type A | -0.0172201 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0170418 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.0168689 |
