| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MBNL2 | muscleblind-like splicing regulator 2 | 0.14947 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.105749 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0981428 |
| NEBL | nebulette | 0.0630325 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0599109 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0586919 |
| FNDC3B | fibronectin type III domain containing 3B | 0.053971 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0476115 |
| PLSCR2 | phospholipid scramblase 2 | 0.0450148 |
| INTS6 | integrator complex subunit 6 | 0.0417356 |
| PHF3 | PHD finger protein 3 | 0.0411302 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0403409 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0396543 |
| HKDC1 | hexokinase domain containing 1 | 0.0379425 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0354511 |
| DST | dystonin | 0.0348468 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0345871 |
| KIF16B | kinesin family member 16B | 0.0340756 |
| VEGFA | vascular endothelial growth factor A | 0.0337959 |
| PDZD8 | PDZ domain containing 8 | 0.03359 |
| ARRDC3 | arrestin domain containing 3 | 0.032805 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0327682 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0321665 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0311744 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0310811 |
| ATXN1 | ataxin 1 | 0.0291941 |
| FNIP1 | folliculin interacting protein 1 | 0.027576 |
| MUC13 | mucin 13, cell surface associated | 0.0275689 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0268247 |
| USP12 | ubiquitin specific peptidase 12 | 0.02599 |
| GSDMB | gasdermin B | 0.0256381 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0254167 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0252539 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0240209 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0238983 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0235531 |
| NDRG1 | N-myc downstream regulated 1 | 0.0232649 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0230778 |
| SCARB1 | scavenger receptor class B, member 1 | 0.0224794 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0224531 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0224451 |
| ZNF292 | zinc finger protein 292 | 0.0221109 |
| PDS5B | PDS5 cohesin associated factor B | 0.0220924 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0217142 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.0216379 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0215794 |
| UBL3 | ubiquitin-like 3 | 0.020638 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0206042 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0205719 |
| ZNF652 | zinc finger protein 652 | 0.0205163 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0204546 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0203129 |
| RNF145 | ring finger protein 145 | 0.020198 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0200696 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0198023 |
| EHF | ets homologous factor | 0.0196116 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0194989 |
| MYO5B | myosin VB | 0.0194833 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0193017 |
| MLPH | melanophilin | 0.0192602 |
| SFTPA2 | surfactant protein A2 | 0.0188929 |
| ZNF148 | zinc finger protein 148 | 0.0187039 |
| KAZN | kazrin, periplakin interacting protein | 0.0186846 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0185605 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0182919 |
| MED13L | mediator complex subunit 13-like | 0.0182149 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | 0.0179112 |
| BNIP5 | BCL2 interacting protein 5 | 0.0178998 |
| ITM2B | integral membrane protein 2B | 0.0174709 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.01738 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0173035 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0171979 |
| ERP44 | endoplasmic reticulum protein 44 | 0.0171902 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0171278 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0169999 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0169119 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | 0.0168254 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0166717 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.016564 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0164563 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | 0.0164265 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0162681 |
| CCPG1 | cell cycle progression 1 | 0.0162291 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0161745 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0161435 |
| KIF26B | kinesin family member 26B | 0.0160874 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0159883 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0158242 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.0158167 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0158048 |
| SETX | senataxin | 0.0156132 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0155828 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.015571 |
| MYO10 | myosin X | 0.0155098 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0154182 |
| APOL2 | apolipoprotein L, 2 | 0.0151359 |
| CDK19 | cyclin-dependent kinase 19 | 0.0151196 |
| GOSR2 | golgi SNAP receptor complex member 2 | 0.0150685 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0148842 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 0.0146524 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.15323 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.136938 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.126112 |
| B2M | beta-2-microglobulin | -0.122617 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.105776 |
| PTMA | prothymosin, alpha | -0.104076 |
| MACC1 | metastasis associated in colon cancer 1 | -0.101561 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0950501 |
| HLA-B | major histocompatibility complex, class I, B | -0.094989 |
| EZR | ezrin | -0.0883089 |
| LCN2 | lipocalin 2 | -0.085318 |
| ITGA6 | integrin, alpha 6 | -0.0810635 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0801983 |
| RUNX1 | runt-related transcription factor 1 | -0.0673335 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0643704 |
| ATP11A | ATPase, class VI, type 11A | -0.0634265 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0617827 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0607999 |
| VCL | vinculin | -0.0566765 |
| MEIS2 | Meis homeobox 2 | -0.0555532 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0554146 |
| H1-0 | H1.0 linker histone | -0.0547964 |
| PERP | PERP, TP53 apoptosis effector | -0.0525996 |
| EPHB2 | EPH receptor B2 | -0.0523014 |
| RPL35A | ribosomal protein L35a | -0.0522763 |
| NF1 | neurofibromin 1 | -0.0518942 |
| RPS6 | ribosomal protein S6 | -0.0510038 |
| ANXA2 | annexin A2 | -0.0504091 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0497136 |
| PRKCA | protein kinase C, alpha | -0.0496933 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0492859 |
| TMSB10 | thymosin beta 10 | -0.0488744 |
| ABLIM1 | actin binding LIM protein 1 | -0.0487686 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0482912 |
| XAF1 | XIAP associated factor 1 | -0.0471086 |
| SPATA13 | spermatogenesis associated 13 | -0.0466049 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0465158 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0457614 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0455967 |
| FTL | ferritin, light polypeptide | -0.0454643 |
| RPS24 | ribosomal protein S24 | -0.0453635 |
| MKI67 | marker of proliferation Ki-67 | -0.0451023 |
| RRBP1 | ribosome binding protein 1 | -0.044719 |
| MT2A | metallothionein 2A | -0.0446612 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0437869 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0431866 |
| EGR1 | early growth response 1 | -0.0423759 |
| NCKAP5 | NCK-associated protein 5 | -0.0417697 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0415203 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0402982 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0400524 |
| RPL23 | ribosomal protein L23 | -0.0394025 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0392361 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0389811 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0385658 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0385363 |
| HLA-C | major histocompatibility complex, class I, C | -0.0385358 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0376302 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0374873 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0372562 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0370477 |
| RBM39 | RNA binding motif protein 39 | -0.0370014 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0364989 |
| SDC4 | syndecan 4 | -0.0358677 |
| PLSCR1 | phospholipid scramblase 1 | -0.0357052 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0356802 |
| RPS8 | ribosomal protein S8 | -0.0354053 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0351243 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0346624 |
| TMC5 | transmembrane channel-like 5 | -0.0346426 |
| RNF43 | ring finger protein 43 | -0.0345816 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0344921 |
| TMEM62 | transmembrane protein 62 | -0.0342259 |
| S100A10 | S100 calcium binding protein A10 | -0.0341682 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0340904 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.034085 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0337726 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.03377 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.033707 |
| S100A6 | S100 calcium binding protein A6 | -0.0336859 |
| LOC112694756 | uncharaterized LOC112694756 | -0.033305 |
| IL20RA | interleukin 20 receptor, alpha | -0.0330279 |
| RPL34 | ribosomal protein L34 | -0.0328117 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0327804 |
| IRS2 | insulin receptor substrate 2 | -0.032505 |
| MX2 | MX dynamin-like GTPase 2 | -0.0324245 |
| MORF4L2 | mortality factor 4 like 2 | -0.0323179 |
| ZNRF3 | zinc and ring finger 3 | -0.0322516 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0319912 |
| DSTN | destrin (actin depolymerizing factor) | -0.0312041 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0308673 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0307938 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0305961 |
| IRF1 | interferon regulatory factor 1 | -0.0305855 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0303338 |
| FOXP1 | forkhead box P1 | -0.0299616 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0299004 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0298635 |
| RIGI | RNA sensor RIG-I | -0.029762 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0294172 |
