Trametinib (DMSO_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib (DMSO perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib (DMSO_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.337475
CANX calnexin 0.101756
NDRG1 N-myc downstream regulated 1 0.0868945
EGFR epidermal growth factor receptor 0.0816929
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0750101
MYOF myoferlin 0.0667794
TNS3 tensin 3 0.0640471
ZNF395 zinc finger protein 395 0.063203
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0629994
SMAD3 SMAD family member 3 0.0601742
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0599405
CALR calreticulin 0.0599309
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0595963
COL5A1 collagen, type V, alpha 1 0.056621
FAM13A family with sequence similarity 13, member A 0.0539645
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0537083
OGA O-GlcNAcase 0.0531295
AHNAK AHNAK nucleoprotein 0.0522494
NAV2 neuron navigator 2 0.0504461
FLNB filamin B, beta 0.0498056
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0493108
ZNF292 zinc finger protein 292 0.0490991
AVL9 AVL9 homolog (S. cerevisiase) 0.0485893
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0460179
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0458698
PRELID2 PRELI domain containing 2 0.045371
CCDC14 coiled-coil domain containing 14 0.0433539
FNDC3B fibronectin type III domain containing 3B 0.0431876
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0419376
ENO1 enolase 1, (alpha) 0.0417755
TPM3 tropomyosin 3 0.0410283
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0397932
TNIP1 TNFAIP3 interacting protein 1 0.0397114
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0381868
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0379174
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0370111
LOXL2 lysyl oxidase-like 2 0.0367518
TXNIP thioredoxin interacting protein 0.0366047
MEF2A myocyte enhancer factor 2A 0.0357815
RNF220 ring finger protein 220 0.0354343
DDIT4 DNA-damage-inducible transcript 4 0.0352892
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0345455
DGKD diacylglycerol kinase, delta 130kDa 0.0343976
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0336223
ZNF841 zinc finger protein 841 0.0330496
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0330302
SFXN1 sideroflexin 1 0.0322369
SHB Src homology 2 domain containing adaptor protein B 0.0316121
SBF2 SET binding factor 2 0.0314218
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0306617
SQSTM1 sequestosome 1 0.0304208
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.029987
FRMD6 FERM domain containing 6 0.0288415
STC2 stanniocalcin 2 0.0288133
ANXA2 annexin A2 0.028714
CAMTA1 calmodulin binding transcription activator 1 0.0285104
YEATS2 YEATS domain containing 2 0.0284989
GYS1 glycogen synthase 1 (muscle) 0.0284088
NFE2L1 nuclear factor, erythroid 2-like 1 0.027876
CD47 CD47 molecule 0.0277556
MT1X metallothionein 1X 0.0273957
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0273636
GPR173 G protein-coupled receptor 173 0.0270822
MT2A metallothionein 2A 0.0266991
KMT2A lysine (K)-specific methyltransferase 2A 0.026505
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0264293
CADM1 cell adhesion molecule 1 0.0263287
PRKCSH protein kinase C substrate 80K-H 0.0261024
ANK2 ankyrin 2, neuronal 0.0260867
TGFBI transforming growth factor, beta-induced, 68kDa 0.025996
CHD1L chromodomain helicase DNA binding protein 1-like 0.0257655
PGK1 phosphoglycerate kinase 1 0.0257003
RPL5 ribosomal protein L5 0.025452
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0254373
LPP LIM domain containing preferred translocation partner in lipoma 0.0253994
EEF2 eukaryotic translation elongation factor 2 0.0253004
ESYT2 extended synaptotagmin-like protein 2 0.025005
MYH9 myosin, heavy chain 9, non-muscle 0.0248747
USP24 ubiquitin specific peptidase 24 0.0247779
ANO6 anoctamin 6 0.0246722
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0245968
AKAP10 A kinase (PRKA) anchor protein 10 0.0242305
DPYSL2 dihydropyrimidinase-like 2 0.0241522
XPO1 exportin 1 0.0238441
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0237975
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0236021
RPL37A ribosomal protein L37a 0.0234086
CD99 CD99 molecule 0.0234022
ANXA1 annexin A1 0.0233828
MYO1B myosin IB 0.023199
FBXO42 F-box protein 42 0.022939
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0229012
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0229001
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0228831
SUCO SUN domain containing ossification factor 0.022876
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0228047
RPL13A ribosomal protein L13a 0.0227351
VEGFA vascular endothelial growth factor A 0.0224821
UGCG UDP-glucose ceramide glucosyltransferase 0.0224699
TTC3 tetratricopeptide repeat domain 3 0.0224223

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.171092
IGFBP3 insulin-like growth factor binding protein 3 -0.142331
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111432
TMSB10 thymosin beta 10 -0.0989565
KYNU kynureninase -0.0948868
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.087391
EGR1 early growth response 1 -0.0871994
EXT1 exostosin glycosyltransferase 1 -0.0737067
ASPH aspartate beta-hydroxylase -0.0731706
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0706173
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0697681
FN1 fibronectin 1 -0.0643457
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.058226
VCL vinculin -0.0567993
PDLIM5 PDZ and LIM domain 5 -0.0553676
VIM vimentin -0.0512142
INHBA inhibin, beta A -0.0491864
RAB7A RAB7A, member RAS oncogene family -0.0480227
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.042778
CD44 CD44 molecule (Indian blood group) -0.0427062
LMAN1 lectin, mannose-binding, 1 -0.0425747
IGFBP5 insulin-like growth factor binding protein 5 -0.0418594
HIPK2 homeodomain interacting protein kinase 2 -0.0414539
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0406496
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0398297
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.039426
HLA-B major histocompatibility complex, class I, B -0.0381202
SCFD1 sec1 family domain containing 1 -0.0374134
ANTXR2 anthrax toxin receptor 2 -0.0373044
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0369708
NAMPT nicotinamide phosphoribosyltransferase -0.0354267
TNNC1 troponin C type 1 (slow) -0.0342296
ZFAND3 zinc finger, AN1-type domain 3 -0.0341894
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0341573
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.034156
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0340447
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.03303
RUNX2 runt-related transcription factor 2 -0.0330087
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0328477
IGF2 insulin-like growth factor 2 -0.0327115
RTN4 reticulon 4 -0.0322627
RPLP1 ribosomal protein, large, P1 -0.0318076
PALLD palladin, cytoskeletal associated protein -0.0316585
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0309799
CLMP CXADR-like membrane protein -0.0308432
BZW2 basic leucine zipper and W2 domains 2 -0.0303759
CDK14 cyclin-dependent kinase 14 -0.0303468
ACTN1 actinin, alpha 1 -0.0303246
MCL1 myeloid cell leukemia 1 -0.0297977
RPL28 ribosomal protein L28 -0.0295943
VMP1 vacuole membrane protein 1 -0.0291682
TPM4 tropomyosin 4 -0.0288448
NAV3 neuron navigator 3 -0.0285955
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0273376
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0272662
HMGA1 high mobility group AT-hook 1 -0.027253
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0272335
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0267164
HMGA2 high mobility group AT-hook 2 -0.0266534
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0265686
POTEF POTE ankyrin domain family, member F -0.0264281
NCOA7 nuclear receptor coactivator 7 -0.0264033
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog -0.0262676
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0261433
ACTN4 actinin, alpha 4 -0.0256539
PTK2 protein tyrosine kinase 2 -0.0256095
SMC4 structural maintenance of chromosomes 4 -0.0254731
RPL27A ribosomal protein L27a -0.025317
GPHN gephyrin -0.0252594
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0250376
ARHGAP24 Rho GTPase activating protein 24 -0.0246724
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0242449
ZEB2 zinc finger E-box binding homeobox 2 -0.0240113
GLIPR1 GLI pathogenesis-related 1 -0.0236678
CREB5 cAMP responsive element binding protein 5 -0.0236378
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0236203
SP100 SP100 nuclear antigen -0.0235214
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0233776
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0224991
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0224205
HDLBP high density lipoprotein binding protein -0.022349
VDAC1 voltage-dependent anion channel 1 -0.0223297
OSBPL8 oxysterol binding protein-like 8 -0.0221779
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0220433
PTPRK protein tyrosine phosphatase, receptor type, K -0.0220121
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.021948
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0215601
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0215132
RPL4 ribosomal protein L4 -0.0213445
RPS24 ribosomal protein S24 -0.0212784
JMJD1C jumonji domain containing 1C -0.0212212
PDE4D phosphodiesterase 4D, cAMP-specific -0.0212185
TUBB4B tubulin, beta 4B class IVb -0.0211763
STK17A serine/threonine kinase 17a -0.021139
TM4SF1 transmembrane 4 L six family member 1 -0.0210868
NPC1 Niemann-Pick disease, type C1 -0.0210528
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0209803
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0207353
GLS2 glutaminase 2 (liver, mitochondrial) -0.0207032
WWTR1 WW domain containing transcription regulator 1 -0.0204993