| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CANX | calnexin | 0.10327 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0908173 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0894892 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0773461 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.075452 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0718155 |
| ZNF292 | zinc finger protein 292 | 0.070572 |
| PCBP2 | poly(rC) binding protein 2 | 0.0680167 |
| YEATS2 | YEATS domain containing 2 | 0.0623078 |
| PRELID2 | PRELI domain containing 2 | 0.0589007 |
| DSPP | dentin sialophosphoprotein | 0.058335 |
| OGA | O-GlcNAcase | 0.0573142 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0571711 |
| GOLGA4 | golgin A4 | 0.0560447 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.05428 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0540873 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0526029 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.050669 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0501619 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0494632 |
| TENM3 | teneurin transmembrane protein 3 | 0.0494162 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0479975 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.047259 |
| NEBL | nebulette | 0.0456497 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.045194 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0450595 |
| HELZ | helicase with zinc finger | 0.0450218 |
| CDK19 | cyclin-dependent kinase 19 | 0.0444766 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0442398 |
| B2M | beta-2-microglobulin | 0.0434044 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0430046 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0427761 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0421484 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0420531 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.041838 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0416988 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0413107 |
| RAD51B | RAD51 paralog B | 0.0399294 |
| PTEN | phosphatase and tensin homolog | 0.0398285 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0396021 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.039397 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0389423 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0379591 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0379489 |
| YME1L1 | YME1-like 1 ATPase | 0.0378732 |
| CALR | calreticulin | 0.0377863 |
| TMF1 | TATA element modulatory factor 1 | 0.0376662 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0371687 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0370341 |
| GANAB | glucosidase, alpha; neutral AB | 0.0367969 |
| XPOT | exportin, tRNA | 0.0366492 |
| CNN3 | calponin 3, acidic | 0.0365827 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0363319 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.036062 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0357407 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0350249 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0346954 |
| MAP4 | microtubule-associated protein 4 | 0.0345694 |
| MED13 | mediator complex subunit 13 | 0.034431 |
| SRP54 | signal recognition particle 54kDa | 0.0323522 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.031768 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0316918 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0310713 |
| SHROOM3 | shroom family member 3 | 0.030888 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0308706 |
| PHF21A | PHD finger protein 21A | 0.0307999 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0307424 |
| YTHDC1 | YTH domain containing 1 | 0.0307133 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0306571 |
| WAC | WW domain containing adaptor with coiled-coil | 0.030564 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0304659 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0304279 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0302792 |
| ZNF148 | zinc finger protein 148 | 0.0301873 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0299832 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0299237 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0297386 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.029541 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0295208 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0295004 |
| ZNF451 | zinc finger protein 451 | 0.0292293 |
| PGM3 | phosphoglucomutase 3 | 0.0290848 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0290687 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.028954 |
| ZZZ3 | zinc finger, ZZ-type containing 3 | 0.028875 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0288217 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0286557 |
| TBC1D4 | TBC1 domain family, member 4 | 0.0284364 |
| INSIG2 | insulin induced gene 2 | 0.0283675 |
| APOL2 | apolipoprotein L, 2 | 0.0283156 |
| RBM39 | RNA binding motif protein 39 | 0.0282044 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0280846 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0280715 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0280508 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0279287 |
| UTRN | utrophin | 0.0275665 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0275645 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0273374 |
| ADAR | adenosine deaminase, RNA-specific | 0.0269754 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0269724 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.249025 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.15631 |
| PTMA | prothymosin, alpha | -0.153535 |
| TMSB10 | thymosin beta 10 | -0.137425 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.133069 |
| NDRG1 | N-myc downstream regulated 1 | -0.131663 |
| AHNAK | AHNAK nucleoprotein | -0.0997793 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0925104 |
| TPM4 | tropomyosin 4 | -0.0838472 |
| PKM | pyruvate kinase, muscle | -0.0828724 |
| EGR1 | early growth response 1 | -0.0774947 |
| MT2A | metallothionein 2A | -0.0766196 |
| MKI67 | marker of proliferation Ki-67 | -0.0707095 |
| KRT18 | keratin 18, type I | -0.069556 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0672484 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.064848 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0609709 |
| EGFR | epidermal growth factor receptor | -0.0608427 |
| EZR | ezrin | -0.0608244 |
| MCL1 | myeloid cell leukemia 1 | -0.0605595 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0564711 |
| CENPF | centromere protein F, 350/400kDa | -0.0555667 |
| INTS6 | integrator complex subunit 6 | -0.0537762 |
| ACTG1 | actin gamma 1 | -0.0528183 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0525804 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.051643 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0506772 |
| RRM2 | ribonucleotide reductase M2 | -0.0491477 |
| KRT8 | keratin 8, type II | -0.0484419 |
| HMGA1 | high mobility group AT-hook 1 | -0.0479353 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0462064 |
| POTEF | POTE ankyrin domain family, member F | -0.0455762 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0429548 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0424226 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0422795 |
| S100A10 | S100 calcium binding protein A10 | -0.0418213 |
| TUBA1B | tubulin, alpha 1b | -0.0401991 |
| DIAPH3 | diaphanous-related formin 3 | -0.038762 |
| CCND1 | cyclin D1 | -0.0380107 |
| ANXA2 | annexin A2 | -0.0377659 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0377526 |
| ARF4 | ADP-ribosylation factor 4 | -0.0377335 |
| CDCP1 | CUB domain containing protein 1 | -0.0377046 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0371392 |
| SDC4 | syndecan 4 | -0.0369146 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0357796 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0355945 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0351606 |
| FRMD5 | FERM domain containing 5 | -0.0351289 |
| FLNB | filamin B, beta | -0.035085 |
| ASPH | aspartate beta-hydroxylase | -0.0346177 |
| KIAA1217 | KIAA1217 | -0.0342162 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0336718 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0331486 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0330478 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0329716 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0328605 |
| CADPS | Ca++-dependent secretion activator | -0.0327096 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0322642 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.031664 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0315103 |
| RPS24 | ribosomal protein S24 | -0.0312357 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0309086 |
| EHBP1 | EH domain binding protein 1 | -0.0305508 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0304447 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0304057 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0300505 |
| TUBB | tubulin, beta class I | -0.0296407 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0296161 |
| HMGA2 | high mobility group AT-hook 2 | -0.0294431 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.029099 |
| PKP4 | plakophilin 4 | -0.0282062 |
| SEPTIN10 | septin 10 | -0.0281351 |
| CEP128 | centrosomal protein 128kDa | -0.0280282 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0279015 |
| ITGB4 | integrin, beta 4 | -0.027646 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.027606 |
| TGFB1 | transforming growth factor, beta 1 | -0.0272056 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0270501 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0262229 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0258893 |
| FHIT | fragile histidine triad | -0.025867 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0257983 |
| KLHL29 | kelch-like family member 29 | -0.0256505 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0253979 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0253584 |
| FUS | FUS RNA binding protein | -0.0253462 |
| LRRC23 | leucine rich repeat containing 23 | -0.025332 |
| RPS27A | ribosomal protein S27a | -0.024999 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.024831 |
| KLF12 | Kruppel-like factor 12 | -0.0245955 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | -0.024505 |
| HELLS | helicase, lymphoid-specific | -0.0244345 |
| ANLN | anillin, actin binding protein | -0.0244143 |
| PALD1 | phosphatase domain containing, paladin 1 | -0.0242121 |
| HMGB1 | high mobility group box 1 | -0.0241631 |
| FOSL1 | FOS-like antigen 1 | -0.0240402 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0240052 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0238869 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0236103 |
