| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.122653 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | 0.0891622 |
| ZNF292 | zinc finger protein 292 | 0.0764188 |
| B2M | beta-2-microglobulin | 0.0690267 |
| FTL | ferritin, light polypeptide | 0.0650278 |
| OXR1 | oxidation resistance 1 | 0.0618059 |
| GOLGA4 | golgin A4 | 0.061451 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0562596 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0556598 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0537721 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0514828 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0507853 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0489268 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.048403 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0460612 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0448363 |
| RNF145 | ring finger protein 145 | 0.0424014 |
| MATR3 | matrin 3 | 0.0414801 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0382589 |
| RPS6 | ribosomal protein S6 | 0.0381822 |
| HELZ | helicase with zinc finger | 0.0366595 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0365299 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0364013 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0362709 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0361958 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0360007 |
| PCBP2 | poly(rC) binding protein 2 | 0.0336431 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0336347 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0331111 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0322075 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0320948 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0315549 |
| YTHDC1 | YTH domain containing 1 | 0.031465 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0305872 |
| YBX1 | Y box binding protein 1 | 0.0304783 |
| APP | amyloid beta (A4) precursor protein | 0.0302665 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0301478 |
| RBM39 | RNA binding motif protein 39 | 0.0292704 |
| ENO1 | enolase 1, (alpha) | 0.0290889 |
| APOL1 | apolipoprotein L, 1 | 0.028859 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0284217 |
| ANXA1 | annexin A1 | 0.0283898 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0282217 |
| RPL12 | ribosomal protein L12 | 0.0281275 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.027926 |
| CCNL1 | cyclin L1 | 0.0277981 |
| TRIM2 | tripartite motif containing 2 | 0.027626 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0274347 |
| CALR | calreticulin | 0.0272961 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0268946 |
| NCKAP1 | NCK-associated protein 1 | 0.0267805 |
| RPS8 | ribosomal protein S8 | 0.0267322 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0267307 |
| RPS19 | ribosomal protein S19 | 0.0258837 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0253273 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0252878 |
| GLIS3 | GLIS family zinc finger 3 | 0.025202 |
| DSG2 | desmoglein 2 | 0.0250145 |
| TFG | TRK-fused gene | 0.0249675 |
| SET | SET nuclear proto-oncogene | 0.0248267 |
| USP3 | ubiquitin specific peptidase 3 | 0.0246451 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0246433 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0245503 |
| RAB1A | RAB1A, member RAS oncogene family | 0.024332 |
| CLINT1 | clathrin interactor 1 | 0.0242937 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0242399 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0242128 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0239454 |
| DNM2 | dynamin 2 | 0.0237678 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0236603 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0235768 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0233716 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0232746 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0230751 |
| RLF | rearranged L-myc fusion | 0.0228357 |
| TMF1 | TATA element modulatory factor 1 | 0.0227772 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0227735 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0227552 |
| ITM2B | integral membrane protein 2B | 0.0226271 |
| FAM162A | family with sequence similarity 162, member A | 0.0221875 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0219125 |
| PLCB4 | phospholipase C, beta 4 | 0.0216703 |
| SPOPL | speckle-type POZ protein-like | 0.0214634 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0214052 |
| SQSTM1 | sequestosome 1 | 0.0213312 |
| VEGFA | vascular endothelial growth factor A | 0.0212419 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0212221 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0210305 |
| RPS27 | ribosomal protein S27 | 0.0209732 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0208715 |
| FRK | fyn-related Src family tyrosine kinase | 0.0206312 |
| RPS12 | ribosomal protein S12 | 0.0206123 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0206068 |
| PDS5B | PDS5 cohesin associated factor B | 0.020432 |
| CDC73 | cell division cycle 73 | 0.0204173 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0202886 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0202671 |
| RIOK3 | RIO kinase 3 | 0.0201627 |
| RPL7 | ribosomal protein L7 | 0.019876 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0198504 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.201456 |
| ASPH | aspartate beta-hydroxylase | -0.200634 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.179939 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.140885 |
| HMGA2 | high mobility group AT-hook 2 | -0.105666 |
| CD44 | CD44 molecule (Indian blood group) | -0.09764 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0972006 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0941521 |
| CCND1 | cyclin D1 | -0.0844061 |
| RAD51B | RAD51 paralog B | -0.0811565 |
| LAMC2 | laminin, gamma 2 | -0.0791078 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0782803 |
| SVIL | supervillin | -0.0757063 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0731222 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0728056 |
| AHNAK | AHNAK nucleoprotein | -0.0723524 |
| PRELID2 | PRELI domain containing 2 | -0.0708326 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0694587 |
| TMSB10 | thymosin beta 10 | -0.0670674 |
| SMYD3 | SET and MYND domain containing 3 | -0.0666619 |
| VCL | vinculin | -0.064739 |
| EGFR | epidermal growth factor receptor | -0.0647362 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0631576 |
| FLNB | filamin B, beta | -0.0621885 |
| DIAPH3 | diaphanous-related formin 3 | -0.0598491 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0592962 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0587132 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0586217 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0577334 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0567161 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0550468 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0529345 |
| NF1 | neurofibromin 1 | -0.0527996 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0527508 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0501443 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0496619 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0484749 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0472375 |
| GPR39 | G protein-coupled receptor 39 | -0.0468724 |
| LAMB3 | laminin, beta 3 | -0.0465152 |
| ITGA6 | integrin, alpha 6 | -0.0462532 |
| FHIT | fragile histidine triad | -0.0456718 |
| ATG7 | autophagy related 7 | -0.0452477 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0443743 |
| PCED1B | PC-esterase domain containing 1B | -0.0431717 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0427956 |
| SMAD3 | SMAD family member 3 | -0.0427668 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0424695 |
| INTS6 | integrator complex subunit 6 | -0.041228 |
| LAMA4 | laminin, alpha 4 | -0.0410234 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0409033 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0400783 |
| MACROD2 | MACRO domain containing 2 | -0.0397962 |
| RUNX1 | runt-related transcription factor 1 | -0.0396204 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0393918 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0389457 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0386 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0381801 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.037863 |
| EHBP1 | EH domain binding protein 1 | -0.0377659 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0370535 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.036984 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0365498 |
| ACTG1 | actin gamma 1 | -0.0362501 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0361708 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0361311 |
| ATXN1 | ataxin 1 | -0.0360914 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0360629 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0355534 |
| DENND1A | DENN/MADD domain containing 1A | -0.035462 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0352828 |
| CDCP1 | CUB domain containing protein 1 | -0.0350898 |
| BPTF | bromodomain PHD finger transcription factor | -0.0349075 |
| WWOX | WW domain containing oxidoreductase | -0.0347777 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.034771 |
| ECT2 | epithelial cell transforming 2 | -0.0336904 |
| SNX14 | sorting nexin 14 | -0.0334129 |
| CCDC138 | coiled-coil domain containing 138 | -0.0328664 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0328325 |
| MTAP | methylthioadenosine phosphorylase | -0.0327339 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.032721 |
| ABR | active BCR-related | -0.0326869 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0326177 |
| EGR1 | early growth response 1 | -0.0321923 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0318818 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0317876 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0317747 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0315721 |
| ZRANB3 | zinc finger, RAN-binding domain containing 3 | -0.0308559 |
| TGFA | transforming growth factor, alpha | -0.0307633 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0306159 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0304879 |
| ANXA3 | annexin A3 | -0.0299533 |
| RASA3 | RAS p21 protein activator 3 | -0.0298205 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0296237 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0294956 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0293548 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0291932 |
| AEBP2 | AE binding protein 2 | -0.0291779 |
| NABP1 | nucleic acid binding protein 1 | -0.0291388 |
