| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.267003 |
| FAM13A | family with sequence similarity 13, member A | 0.0948566 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0878767 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0838662 |
| PTMA | prothymosin, alpha | 0.0782964 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0732113 |
| NDRG1 | N-myc downstream regulated 1 | 0.0700236 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0647052 |
| PCBP3 | poly(rC) binding protein 3 | 0.0563896 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0529202 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.049915 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0494322 |
| ARRDC3 | arrestin domain containing 3 | 0.0480849 |
| CANX | calnexin | 0.0450438 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0445085 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0433952 |
| ADM | adrenomedullin | 0.0428395 |
| ANTXR1 | anthrax toxin receptor 1 | 0.042158 |
| ZNF292 | zinc finger protein 292 | 0.0415374 |
| SEPTIN9 | septin 9 | 0.0414201 |
| MEF2A | myocyte enhancer factor 2A | 0.0413919 |
| CD109 | CD109 molecule | 0.0413454 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.040113 |
| OGA | O-GlcNAcase | 0.0400007 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0399831 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0389883 |
| TXNIP | thioredoxin interacting protein | 0.0375047 |
| ZNF148 | zinc finger protein 148 | 0.0353179 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0352833 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0352291 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0349638 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0345736 |
| HELZ | helicase with zinc finger | 0.0339135 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0328645 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0328294 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0328143 |
| CENPF | centromere protein F, 350/400kDa | 0.0319353 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0316311 |
| RNF220 | ring finger protein 220 | 0.0314779 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0313657 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0308824 |
| THBS1 | thrombospondin 1 | 0.0307977 |
| IRS2 | insulin receptor substrate 2 | 0.0307951 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0306823 |
| ZNF395 | zinc finger protein 395 | 0.0306126 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0303572 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0300758 |
| PDE10A | phosphodiesterase 10A | 0.0300647 |
| ENO1 | enolase 1, (alpha) | 0.0293156 |
| FAM162A | family with sequence similarity 162, member A | 0.0287558 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0283827 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0279892 |
| MYOF | myoferlin | 0.0278622 |
| QKI | QKI, KH domain containing, RNA binding | 0.0278531 |
| HMGB2 | high mobility group box 2 | 0.02706 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.027058 |
| GANAB | glucosidase, alpha; neutral AB | 0.0265937 |
| ANLN | anillin, actin binding protein | 0.0265456 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.026381 |
| SFXN1 | sideroflexin 1 | 0.0263678 |
| WDR45B | WD repeat domain 45B | 0.0262399 |
| LOX | lysyl oxidase | 0.0255434 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0255064 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.0254348 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0252649 |
| RNF24 | ring finger protein 24 | 0.0252594 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0241324 |
| SPAG9 | sperm associated antigen 9 | 0.0239472 |
| GOLGA4 | golgin A4 | 0.0236698 |
| USP3 | ubiquitin specific peptidase 3 | 0.0234339 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0225884 |
| RPL12 | ribosomal protein L12 | 0.0223636 |
| PGK1 | phosphoglycerate kinase 1 | 0.0222995 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0222651 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0214129 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0213595 |
| RLF | rearranged L-myc fusion | 0.0206619 |
| MT1X | metallothionein 1X | 0.0206231 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0206074 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.020317 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.020253 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0202397 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0202104 |
| LDHA | lactate dehydrogenase A | 0.0201602 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0201474 |
| CCND1 | cyclin D1 | 0.0199404 |
| RPS19 | ribosomal protein S19 | 0.0197669 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0197319 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0197161 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0195181 |
| CALU | calumenin | 0.0192915 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.0192014 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0191742 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0191579 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0191579 |
| CKAP5 | cytoskeleton associated protein 5 | 0.01913 |
| YBX1 | Y box binding protein 1 | 0.0190842 |
| CEP192 | centrosomal protein 192kDa | 0.019024 |
| CDK19 | cyclin-dependent kinase 19 | 0.018992 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0189504 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | -0.171433 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.170207 |
| HMGA2 | high mobility group AT-hook 2 | -0.15544 |
| ASPH | aspartate beta-hydroxylase | -0.140419 |
| VIM | vimentin | -0.131702 |
| EXT1 | exostosin glycosyltransferase 1 | -0.128051 |
| FN1 | fibronectin 1 | -0.125626 |
| CDH13 | cadherin 13 | -0.122123 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.10072 |
| IGF2 | insulin-like growth factor 2 | -0.0926967 |
| CD44 | CD44 molecule (Indian blood group) | -0.0889787 |
| EGR1 | early growth response 1 | -0.0865516 |
| MYO10 | myosin X | -0.0864115 |
| TMSB10 | thymosin beta 10 | -0.083038 |
| CLMP | CXADR-like membrane protein | -0.0772169 |
| NAV1 | neuron navigator 1 | -0.0698925 |
| DST | dystonin | -0.0675792 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0668922 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0668468 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.066723 |
| STC1 | stanniocalcin 1 | -0.0651207 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0627778 |
| DTNA | dystrobrevin, alpha | -0.0611342 |
| INHBA | inhibin, beta A | -0.0589974 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0560306 |
| GLIS3 | GLIS family zinc finger 3 | -0.0524681 |
| FMN1 | formin 1 | -0.0523005 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0509568 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.048905 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0482218 |
| TENM2 | teneurin transmembrane protein 2 | -0.0476829 |
| PRKCA | protein kinase C, alpha | -0.0473879 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0472991 |
| MCL1 | myeloid cell leukemia 1 | -0.0472458 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0469892 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0467441 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.045622 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0448977 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0441936 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0435384 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0433205 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0425009 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.041022 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0405637 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0399567 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0394903 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0380407 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0369524 |
| ATXN1 | ataxin 1 | -0.0367049 |
| DIAPH2 | diaphanous-related formin 2 | -0.0360477 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0354286 |
| IL1B | interleukin 1, beta | -0.0348947 |
| ACTG1 | actin gamma 1 | -0.0345517 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.034413 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0342855 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0341432 |
| MAP1B | microtubule-associated protein 1B | -0.0338764 |
| MSN | moesin | -0.0309323 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0305134 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0303781 |
| TPM4 | tropomyosin 4 | -0.0303038 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0299875 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0287346 |
| FRMD4A | FERM domain containing 4A | -0.0282771 |
| NAV3 | neuron navigator 3 | -0.0279393 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0278374 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0276189 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0275853 |
| LAMB3 | laminin, beta 3 | -0.027514 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0272436 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0272021 |
| SEC24D | SEC24 family member D | -0.0270726 |
| PLEC | plectin | -0.0269976 |
| PALLD | palladin, cytoskeletal associated protein | -0.026424 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0261668 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0261422 |
| CLIC4 | chloride intracellular channel 4 | -0.0260046 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0259119 |
| ATG7 | autophagy related 7 | -0.0258985 |
| PDLIM5 | PDZ and LIM domain 5 | -0.025876 |
| ACTN4 | actinin, alpha 4 | -0.0257256 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0257065 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0254876 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0253037 |
| EGFR | epidermal growth factor receptor | -0.0250123 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0249218 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0248158 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0247481 |
| IL11 | interleukin 11 | -0.0247198 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0244646 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0243703 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0242304 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0241771 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0240428 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0240199 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0240083 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0239093 |
| MYO9B | myosin IXB | -0.0237083 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0235975 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.0233255 |
