| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.175876 |
| MT2A | metallothionein 2A | 0.128509 |
| FN1 | fibronectin 1 | 0.112783 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0857833 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0763591 |
| VEGFA | vascular endothelial growth factor A | 0.0741605 |
| CALR | calreticulin | 0.0692017 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.067517 |
| ARRDC3 | arrestin domain containing 3 | 0.0666031 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0554285 |
| PRELID2 | PRELI domain containing 2 | 0.050788 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0465249 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0452458 |
| SMAD3 | SMAD family member 3 | 0.0434315 |
| GANAB | glucosidase, alpha; neutral AB | 0.0423819 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0421642 |
| RNF220 | ring finger protein 220 | 0.039499 |
| ENO1 | enolase 1, (alpha) | 0.0377594 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0375004 |
| ZNF292 | zinc finger protein 292 | 0.0365674 |
| SPAG9 | sperm associated antigen 9 | 0.036389 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.036377 |
| GOLGA4 | golgin A4 | 0.0352233 |
| ATP13A3 | ATPase type 13A3 | 0.0336625 |
| HLA-A | major histocompatibility complex, class I, A | 0.0335171 |
| NAV2 | neuron navigator 2 | 0.0326639 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0323822 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0318905 |
| PTMA | prothymosin, alpha | 0.0318117 |
| LOXL2 | lysyl oxidase-like 2 | 0.0309716 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0296678 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0289942 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0288572 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0281459 |
| HIP1 | huntingtin interacting protein 1 | 0.0275889 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0274105 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0266266 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0265749 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0265115 |
| PDE10A | phosphodiesterase 10A | 0.0252902 |
| SOCS5 | suppressor of cytokine signaling 5 | 0.0246344 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0245383 |
| FLNB | filamin B, beta | 0.0239584 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0237306 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0231213 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0225063 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.022489 |
| ADM | adrenomedullin | 0.0224131 |
| SVIL | supervillin | 0.0222565 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0219859 |
| MT1X | metallothionein 1X | 0.0218121 |
| FMNL2 | formin-like 2 | 0.021704 |
| TMEM65 | transmembrane protein 65 | 0.0215193 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0214288 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0213978 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0213606 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0211741 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0209021 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0208514 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0208129 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0207943 |
| TRIM33 | tripartite motif containing 33 | 0.0207605 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0206864 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0206125 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0196108 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0195125 |
| ANGPTL4 | angiopoietin-like 4 | 0.0194372 |
| UTRN | utrophin | 0.0192725 |
| RPS2 | ribosomal protein S2 | 0.0192109 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0191634 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0191619 |
| FAT1 | FAT atypical cadherin 1 | 0.0190098 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0189052 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0187446 |
| MED13L | mediator complex subunit 13-like | 0.0186647 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0185973 |
| B2M | beta-2-microglobulin | 0.0184905 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0183579 |
| FAM20C | family with sequence similarity 20, member C | 0.0183008 |
| ECT2 | epithelial cell transforming 2 | 0.0182394 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0181155 |
| CANX | calnexin | 0.017991 |
| MSL1 | male-specific lethal 1 homolog (Drosophila) | 0.0176957 |
| RPL12 | ribosomal protein L12 | 0.0175524 |
| DNM2 | dynamin 2 | 0.0175177 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | 0.0173449 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0173021 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0171936 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.017082 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.017015 |
| RPS19 | ribosomal protein S19 | 0.0170041 |
| KIF1B | kinesin family member 1B | 0.0169359 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0168116 |
| CENPF | centromere protein F, 350/400kDa | 0.0166252 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0165391 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 0.0163327 |
| FNBP1L | formin binding protein 1-like | 0.0161539 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0160523 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0159243 |
| SH3PXD2B | SH3 and PX domains 2B | 0.0159099 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.203011 |
| NDRG1 | N-myc downstream regulated 1 | -0.145116 |
| COL1A1 | collagen, type I, alpha 1 | -0.108158 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.10486 |
| FBN1 | fibrillin 1 | -0.103942 |
| INHBA | inhibin, beta A | -0.102668 |
| VIM | vimentin | -0.0995167 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.097292 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0917827 |
| TMSB10 | thymosin beta 10 | -0.0808716 |
| CADM1 | cell adhesion molecule 1 | -0.079852 |
| ASPH | aspartate beta-hydroxylase | -0.079135 |
| CALD1 | caldesmon 1 | -0.0727105 |
| STC1 | stanniocalcin 1 | -0.072267 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0684315 |
| IER3 | immediate early response 3 | -0.065602 |
| TPM4 | tropomyosin 4 | -0.0632266 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0625225 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0597959 |
| CDH13 | cadherin 13 | -0.0583574 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0566875 |
| EGR1 | early growth response 1 | -0.0534782 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0493017 |
| SDC2 | syndecan 2 | -0.0490401 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0465771 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0435786 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0427893 |
| CLMP | CXADR-like membrane protein | -0.0426777 |
| RIGI | RNA sensor RIG-I | -0.0420591 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0389241 |
| HMGA2 | high mobility group AT-hook 2 | -0.0383515 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0378384 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0360348 |
| CALU | calumenin | -0.0354501 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0351758 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0351374 |
| COL1A2 | collagen, type I, alpha 2 | -0.0347393 |
| VCL | vinculin | -0.0347114 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0327349 |
| SEC24D | SEC24 family member D | -0.0324542 |
| POTEF | POTE ankyrin domain family, member F | -0.0323807 |
| ACTG1 | actin gamma 1 | -0.0322423 |
| RND3 | Rho family GTPase 3 | -0.031833 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0312967 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0309666 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0307572 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0295549 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0291689 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0290856 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0288683 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0285677 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0284894 |
| TMSB4X | thymosin beta 4, X-linked | -0.0283413 |
| CLIC4 | chloride intracellular channel 4 | -0.0278551 |
| OXR1 | oxidation resistance 1 | -0.027612 |
| GLIS3 | GLIS family zinc finger 3 | -0.0273671 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0272718 |
| OSMR | oncostatin M receptor | -0.0271433 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0269302 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0268054 |
| CCDC80 | coiled-coil domain containing 80 | -0.0263027 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0262964 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.025702 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0254905 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0254198 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0250567 |
| TSC22D2 | TSC22 domain family, member 2 | -0.024633 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0244672 |
| ACTN1 | actinin, alpha 1 | -0.0244429 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0242989 |
| SP100 | SP100 nuclear antigen | -0.0236914 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0234138 |
| COL5A1 | collagen, type V, alpha 1 | -0.0234036 |
| BNC2 | basonuclin 2 | -0.0230849 |
| ZNF644 | zinc finger protein 644 | -0.0230022 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0229188 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0226789 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0225859 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.0225629 |
| RPS24 | ribosomal protein S24 | -0.0224835 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0223642 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0221605 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0219829 |
| IL6ST | interleukin 6 signal transducer | -0.0218197 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0218091 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0217168 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0215021 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0214235 |
| NREP | neuronal regeneration related protein | -0.0214052 |
| MTPN | myotrophin | -0.021332 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.021128 |
| CLINT1 | clathrin interactor 1 | -0.0210377 |
| PALLD | palladin, cytoskeletal associated protein | -0.0210016 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0209926 |
| FSTL1 | follistatin-like 1 | -0.0209888 |
| NAV3 | neuron navigator 3 | -0.0208648 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0208606 |
| COL3A1 | collagen, type III, alpha 1 | -0.0205442 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0205112 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0203989 |
