Trametinib (DMSO_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib (DMSO perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib (DMSO_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8 0.0945042
SAMD12 sterile alpha motif domain containing 12 0.0840747
TXNRD1 thioredoxin reductase 1 0.0781364
GCLC glutamate-cysteine ligase, catalytic subunit 0.0694883
KMT2C lysine (K)-specific methyltransferase 2C 0.0633126
PDZD8 PDZ domain containing 8 0.0599566
MBNL2 muscleblind-like splicing regulator 2 0.0584809
PTPRK protein tyrosine phosphatase, receptor type, K 0.0552383
PTK2 protein tyrosine kinase 2 0.0534792
KDM6A lysine (K)-specific demethylase 6A 0.0530101
PELI1 pellino E3 ubiquitin protein ligase 1 0.0501903
TMC5 transmembrane channel-like 5 0.0485294
OGA O-GlcNAcase 0.0469634
TRPS1 trichorhinophalangeal syndrome I 0.0468932
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0448033
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0432467
FBXO32 F-box protein 32 0.0420304
ZNF292 zinc finger protein 292 0.0409045
GMDS GDP-mannose 4,6-dehydratase 0.040701
PDE4D phosphodiesterase 4D, cAMP-specific 0.0392198
FTH1 ferritin, heavy polypeptide 1 0.0383973
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0382252
NAMPT nicotinamide phosphoribosyltransferase 0.0379109
EXT1 exostosin glycosyltransferase 1 0.0374866
SQSTM1 sequestosome 1 0.037422
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0372877
ATXN1 ataxin 1 0.0372614
EHF ets homologous factor 0.0368471
FNDC3B fibronectin type III domain containing 3B 0.0364971
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0363
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0362806
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0355152
RNF213 ring finger protein 213 0.0352009
FNIP1 folliculin interacting protein 1 0.0342316
PRELID2 PRELI domain containing 2 0.0331919
MYO5B myosin VB 0.0331055
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0329761
CANX calnexin 0.0325759
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0323239
ANKRD12 ankyrin repeat domain 12 0.0322784
CTNND1 catenin (cadherin-associated protein), delta 1 0.0319391
HELZ helicase with zinc finger 0.0318296
JMJD1C jumonji domain containing 1C 0.0314278
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0310049
TUFT1 tuftelin 1 0.0309395
ZMYM2 zinc finger, MYM-type 2 0.030913
SPTBN1 spectrin, beta, non-erythrocytic 1 0.030711
KDM3A lysine (K)-specific demethylase 3A 0.0304351
BIRC3 baculoviral IAP repeat containing 3 0.0301047
PGCKA1 PDCD10 and GCKIII kinases associated 1 0.0297112
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0295013
USP54 ubiquitin specific peptidase 54 0.0294813
MUC13 mucin 13, cell surface associated 0.0291392
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0289033
KLF6 Kruppel-like factor 6 0.0284457
AFDN afadin, adherens junction formation factor 0.0282477
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0277125
HHLA2 HERV-H LTR-associating 2 0.0276784
MACC1 metastasis associated in colon cancer 1 0.0276294
KLF5 Kruppel-like factor 5 (intestinal) 0.0276095
RAD21 RAD21 homolog (S. pombe) 0.0274474
TM4SF4 transmembrane 4 L six family member 4 0.027132
CD2AP CD2-associated protein 0.0270573
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0267678
RBM39 RNA binding motif protein 39 0.0266946
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0266335
USP3 ubiquitin specific peptidase 3 0.0262952
SBF2 SET binding factor 2 0.0260439
PTEN phosphatase and tensin homolog 0.0259904
LCORL ligand dependent nuclear receptor corepressor-like 0.0258315
AHNAK AHNAK nucleoprotein 0.025807
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0257458
IFRD1 interferon-related developmental regulator 1 0.0253873
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0249033
PDS5B PDS5 cohesin associated factor B 0.0246772
PSPC1 paraspeckle component 1 0.0246337
MTAP methylthioadenosine phosphorylase 0.0245879
CYRIB CYFIP related Rac1 interactor B 0.0245118
EWSR1 EWS RNA-binding protein 1 0.0240589
RBM33 RNA binding motif protein 33 0.0239346
DSCAM Down syndrome cell adhesion molecule 0.0238601
TRA2A transformer 2 alpha homolog (Drosophila) 0.0238251
SND1 staphylococcal nuclease and tudor domain containing 1 0.0233895
EPB41 erythrocyte membrane protein band 4.1 0.0233517
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0231883
YTHDC1 YTH domain containing 1 0.0231705
NEK7 NIMA-related kinase 7 0.0228856
CEMIP2 cell migration inducing hyaluronidase 2 0.0227935
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0226533
JAK1 Janus kinase 1 0.022637
ARHGAP32 Rho GTPase activating protein 32 0.022569
GSK3B glycogen synthase kinase 3 beta 0.0224219
RND3 Rho family GTPase 3 0.0223469
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0222597
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0218999
MECOM MDS1 and EVI1 complex locus 0.0217868
DSPP dentin sialophosphoprotein 0.0217571
FAM91A1 family with sequence similarity 91, member A1 0.0216189
EIF4B eukaryotic translation initiation factor 4B 0.0216052
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0216015

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.244616
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.151397
TMSB10 thymosin beta 10 -0.146701
RPS6 ribosomal protein S6 -0.13184
RPLP1 ribosomal protein, large, P1 -0.119933
EGR1 early growth response 1 -0.119094
RPL23 ribosomal protein L23 -0.109223
RPS19 ribosomal protein S19 -0.10789
NDRG1 N-myc downstream regulated 1 -0.0909268
RPL35A ribosomal protein L35a -0.0825205
LOC102724023 ES1 protein homolog, mitochondrial -0.0805449
RPLP2 ribosomal protein, large, P2 -0.077441
RPS8 ribosomal protein S8 -0.0692625
TPT1 tumor protein, translationally-controlled 1 -0.0687762
ACTG1 actin gamma 1 -0.0674335
RPS3 ribosomal protein S3 -0.0671174
RPS13 ribosomal protein S13 -0.0659269
ANXA2 annexin A2 -0.0633831
PTMA prothymosin, alpha -0.0623954
RPS16 ribosomal protein S16 -0.0601238
RPL31 ribosomal protein L31 -0.0586203
ITPKC inositol-trisphosphate 3-kinase C -0.0579446
LYZ lysozyme -0.0572747
RPL28 ribosomal protein L28 -0.0554143
RPL9 ribosomal protein L9 -0.0552961
RPL34 ribosomal protein L34 -0.0546683
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0524911
S100A10 S100 calcium binding protein A10 -0.051806
LOC112694756 uncharaterized LOC112694756 -0.0510559
EIF1 eukaryotic translation initiation factor 1 -0.0506183
RPS5 ribosomal protein S5 -0.0492842
RPS24 ribosomal protein S24 -0.0491944
POTEF POTE ankyrin domain family, member F -0.0489662
WASF2 WAS protein family, member 2 -0.0481661
KRT8 keratin 8, type II -0.0478385
ACTN4 actinin, alpha 4 -0.0470925
RPL13A ribosomal protein L13a -0.0467692
RPS23 ribosomal protein S23 -0.0452696
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0448874
MYL12B myosin, light chain 12B, regulatory -0.0448442
RPL11 ribosomal protein L11 -0.0448295
FOSL1 FOS-like antigen 1 -0.0445888
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0439557
PKM pyruvate kinase, muscle -0.0433261
SLC45A4 solute carrier family 45, member 4 -0.0431385
RPS14 ribosomal protein S14 -0.0427696
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0427583
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0427419
S100P S100 calcium binding protein P -0.042668
RPL37A ribosomal protein L37a -0.0425558
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0425145
RPL37 ribosomal protein L37 -0.0424637
RPL18 ribosomal protein L18 -0.0424523
RPS11 ribosomal protein S11 -0.042349
RPL5 ribosomal protein L5 -0.0421649
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0421472
RPL19 ribosomal protein L19 -0.0421421
B2M beta-2-microglobulin -0.0417164
RPS25 ribosomal protein S25 -0.0409979
S100A6 S100 calcium binding protein A6 -0.0409066
RPLP0 ribosomal protein, large, P0 -0.0406599
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0397955
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.039314
KRT18 keratin 18, type I -0.0392885
RPS17 ribosomal protein S17 -0.0392319
RPL12 ribosomal protein L12 -0.0389488
BCL2L1 BCL2-like 1 -0.0387913
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0380691
RPL27A ribosomal protein L27a -0.037179
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0369833
POMP proteasome maturation protein -0.0365695
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0365206
RPS21 ribosomal protein S21 -0.0361999
RPL8 ribosomal protein L8 -0.0361206
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0359635
RPS12 ribosomal protein S12 -0.0358577
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0354293
KLF10 Kruppel-like factor 10 -0.0351646
AREG amphiregulin -0.0351288
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0345318
RPL36A ribosomal protein L36a -0.0344132
RPL7A ribosomal protein L7a -0.0342457
FAT1 FAT atypical cadherin 1 -0.0342112
GNAS GNAS complex locus -0.0340974
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0339008
TJP2 tight junction protein 2 -0.0338918
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0337814
RPL36 ribosomal protein L36 -0.0328117
GARS1 glycyl-tRNA synthetase 1 -0.0322475
JUP junction plakoglobin -0.0319162
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0318755
CLDN4 claudin 4 -0.0318735
RPL21 ribosomal protein L21 -0.0317288
RPS27 ribosomal protein S27 -0.0316198
GCC2 GRIP and coiled-coil domain containing 2 -0.0314069
ITGA6 integrin, alpha 6 -0.0312055
RPS29 ribosomal protein S29 -0.0312052
ZFP36 ZFP36 ring finger protein -0.030961
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0309495
UBE2B ubiquitin-conjugating enzyme E2B -0.0308219