| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LRMDA | leucine rich melanocyte differentiation associated | 0.167051 |
| C3 | complement component 3 | 0.144555 |
| APOB | apolipoprotein B | 0.131772 |
| CFB | complement factor B | 0.116205 |
| TF | transferrin | 0.1027 |
| DSPP | dentin sialophosphoprotein | 0.079739 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0790214 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0717668 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0635779 |
| FABP1 | fatty acid binding protein 1, liver | 0.0594065 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0540293 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0442349 |
| FGA | fibrinogen alpha chain | 0.0439195 |
| DTNA | dystrobrevin, alpha | 0.0434554 |
| FGB | fibrinogen beta chain | 0.0429131 |
| ORM1 | orosomucoid 1 | 0.0410355 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0406495 |
| FGG | fibrinogen gamma chain | 0.0389496 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.0381854 |
| ZNF292 | zinc finger protein 292 | 0.0380933 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0377324 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0371571 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.035337 |
| PRELID2 | PRELI domain containing 2 | 0.0347752 |
| AFDN | afadin, adherens junction formation factor | 0.0342465 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0340644 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0339076 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0334036 |
| GPC3 | glypican 3 | 0.0333152 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0330729 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0328776 |
| ECE1 | endothelin converting enzyme 1 | 0.032366 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0308583 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0306339 |
| ENO1 | enolase 1, (alpha) | 0.0304873 |
| FHIT | fragile histidine triad | 0.0302293 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0299209 |
| EFNA1 | ephrin-A1 | 0.0290215 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0289338 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.028181 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0276898 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0276733 |
| A1CF | APOBEC1 complementation factor | 0.0276045 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0274686 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0269112 |
| RNF213 | ring finger protein 213 | 0.0267143 |
| MED13L | mediator complex subunit 13-like | 0.0266502 |
| RAD51B | RAD51 paralog B | 0.0258846 |
| VEGFA | vascular endothelial growth factor A | 0.0258205 |
| APOA1 | apolipoprotein A-I | 0.0258027 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0257283 |
| MBNL3 | muscleblind-like splicing regulator 3 | 0.025595 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0251865 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0248948 |
| NDRG1 | N-myc downstream regulated 1 | 0.024875 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0248035 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0244831 |
| MYO1B | myosin IB | 0.0241855 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0240179 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0238988 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0238572 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0238222 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.023421 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0233734 |
| ATRN | attractin | 0.0233597 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0230873 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0229324 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0227751 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0221556 |
| HELZ | helicase with zinc finger | 0.0220416 |
| PCBP2 | poly(rC) binding protein 2 | 0.0219026 |
| GOLGA4 | golgin A4 | 0.0218709 |
| DSCAM | Down syndrome cell adhesion molecule | 0.021813 |
| PHF3 | PHD finger protein 3 | 0.0217816 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0215504 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | 0.0214964 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0213402 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0209237 |
| PTK2 | protein tyrosine kinase 2 | 0.0209174 |
| QKI | QKI, KH domain containing, RNA binding | 0.0207495 |
| SMYD3 | SET and MYND domain containing 3 | 0.020027 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0199805 |
| RBM33 | RNA binding motif protein 33 | 0.0198817 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0197701 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0194658 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0194269 |
| MSI2 | musashi RNA-binding protein 2 | 0.0193919 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | 0.0191841 |
| CHKA | choline kinase alpha | 0.0191782 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0190828 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0190518 |
| OPTN | optineurin | 0.0190496 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0189712 |
| PAPOLA | poly(A) polymerase alpha | 0.0188083 |
| A2M | alpha-2-macroglobulin | 0.0187953 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0187328 |
| DENND1A | DENN/MADD domain containing 1A | 0.0185838 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0185106 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0181785 |
| FBXO42 | F-box protein 42 | 0.0181708 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.387477 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.173633 |
| SLC38A2 | solute carrier family 38, member 2 | -0.1384 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.120976 |
| EHBP1 | EH domain binding protein 1 | -0.112779 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.108132 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0880337 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0753484 |
| FRMD5 | FERM domain containing 5 | -0.0730102 |
| MT2A | metallothionein 2A | -0.0695124 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0680667 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0639754 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0611335 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0555695 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0401731 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0397052 |
| ASPH | aspartate beta-hydroxylase | -0.0387089 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0380213 |
| APOA2 | apolipoprotein A-II | -0.0373838 |
| HMGA1 | high mobility group AT-hook 1 | -0.0367874 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0358811 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0345571 |
| VCL | vinculin | -0.0342921 |
| EGR1 | early growth response 1 | -0.0332127 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0327824 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0326133 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0322484 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0312513 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0312426 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0311603 |
| FMNL2 | formin-like 2 | -0.0311153 |
| ITGA1 | integrin, alpha 1 | -0.0309668 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0304323 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0304012 |
| ITGAV | integrin, alpha V | -0.0298732 |
| TMSB10 | thymosin beta 10 | -0.0293778 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0291642 |
| GK | glycerol kinase | -0.0287527 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0286003 |
| NHSL1 | NHS-like 1 | -0.0277117 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0275864 |
| ITGB5 | integrin, beta 5 | -0.0270182 |
| NPR2 | natriuretic peptide receptor 2 | -0.0268404 |
| RPS24 | ribosomal protein S24 | -0.0262817 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0260772 |
| TMEM123 | transmembrane protein 123 | -0.026055 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0251162 |
| FOXP1 | forkhead box P1 | -0.0250002 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0241161 |
| TRIM26 | tripartite motif containing 26 | -0.023304 |
| BCL2L1 | BCL2-like 1 | -0.0231386 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0229101 |
| FAT1 | FAT atypical cadherin 1 | -0.0228703 |
| RAI14 | retinoic acid induced 14 | -0.0225854 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0224776 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0224097 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0223896 |
| FAM135A | family with sequence similarity 135, member A | -0.0221134 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0220574 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.021454 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0213942 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0212831 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0212518 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0208219 |
| HMGA2 | high mobility group AT-hook 2 | -0.0206876 |
| DUSP6 | dual specificity phosphatase 6 | -0.0205953 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0205425 |
| PRKCA | protein kinase C, alpha | -0.0203152 |
| STK17A | serine/threonine kinase 17a | -0.0201995 |
| FAM107B | family with sequence similarity 107, member B | -0.0201539 |
| PERP | PERP, TP53 apoptosis effector | -0.0200827 |
| IER3 | immediate early response 3 | -0.0198193 |
| RUNX1 | runt-related transcription factor 1 | -0.0196467 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0196279 |
| ZFHX3 | zinc finger homeobox 3 | -0.0192642 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0191439 |
| FERMT1 | fermitin family member 1 | -0.0188335 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0182589 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0180386 |
| SVIL | supervillin | -0.0176262 |
| CNKSR3 | CNKSR family member 3 | -0.0175813 |
| ATP10A | ATPase, class V, type 10A | -0.0173395 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0171709 |
| MCL1 | myeloid cell leukemia 1 | -0.0171073 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0170425 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0169237 |
| MALT1 | MALT1 paracaspase | -0.0168322 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0163117 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.015952 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0158114 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0158028 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0157645 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0156651 |
| DENND4A | DENN/MADD domain containing 4A | -0.0156202 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0155921 |
| KRT23 | keratin 23, type I | -0.0154804 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -0.0149649 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0149604 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0149499 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0147761 |
