| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0658612 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0655432 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.061578 |
| AHNAK | AHNAK nucleoprotein | 0.0570902 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0565398 |
| SULF1 | sulfatase 1 | 0.0551643 |
| CLU | clusterin | 0.0517228 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.050881 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0501596 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0465741 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0459029 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0456592 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0455785 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0443503 |
| PLAT | plasminogen activator, tissue | 0.0430455 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0428995 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0419753 |
| IFI44 | interferon-induced protein 44 | 0.0418764 |
| MEF2A | myocyte enhancer factor 2A | 0.0405461 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0376458 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0374305 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0369815 |
| KRT17 | keratin 17, type I | 0.0363955 |
| IFI44L | interferon-induced protein 44-like | 0.0354872 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0348633 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0348296 |
| ADAR | adenosine deaminase, RNA-specific | 0.0342052 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0339857 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0332745 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0328755 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0323933 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0310059 |
| SAMD9L | sterile alpha motif domain containing 9-like | 0.0308864 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0296254 |
| PRELID2 | PRELI domain containing 2 | 0.0279554 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0278542 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0278245 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0277871 |
| RNF152 | ring finger protein 152 | 0.0273614 |
| PLEC | plectin | 0.0259014 |
| MX1 | MX dynamin-like GTPase 1 | 0.0251784 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.024801 |
| KIAA1217 | KIAA1217 | 0.0242418 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0237516 |
| SLC45A4 | solute carrier family 45, member 4 | 0.0237092 |
| ANXA1 | annexin A1 | 0.0234938 |
| RNF213 | ring finger protein 213 | 0.0228615 |
| EGFR | epidermal growth factor receptor | 0.0227229 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.022644 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0224929 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0220451 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.0220347 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0215827 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0212772 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0210424 |
| MECOM | MDS1 and EVI1 complex locus | 0.020797 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0206558 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0206127 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.020538 |
| MXRA5 | matrix-remodelling associated 5 | 0.0201512 |
| AUTS2 | autism susceptibility candidate 2 | 0.0198256 |
| ITGB8 | integrin, beta 8 | 0.0196099 |
| EHF | ets homologous factor | 0.0194999 |
| KRT6A | keratin 6A, type II | 0.0194269 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.019271 |
| ARRDC3 | arrestin domain containing 3 | 0.0188981 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.0188918 |
| DSPP | dentin sialophosphoprotein | 0.0188596 |
| GLYAT | glycine-N-acyltransferase | 0.018846 |
| TXNRD1 | thioredoxin reductase 1 | 0.0186727 |
| GBP4 | guanylate binding protein 4 | 0.0186071 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.0184692 |
| KRT5 | keratin 5, type II | 0.018295 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0181389 |
| NEK7 | NIMA-related kinase 7 | 0.017973 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0177038 |
| TKT | transketolase | 0.0170986 |
| SETBP1 | SET binding protein 1 | 0.0167506 |
| IRF1 | interferon regulatory factor 1 | 0.0166477 |
| CFB | complement factor B | 0.0165885 |
| PLA2R1 | phospholipase A2 receptor 1, 180kDa | 0.0164756 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0164723 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0163758 |
| TJP2 | tight junction protein 2 | 0.016332 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.0163309 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0162826 |
| FOXO1 | forkhead box O1 | 0.0161306 |
| JAK1 | Janus kinase 1 | 0.0159624 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0159523 |
| PTGR1 | prostaglandin reductase 1 | 0.0159317 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0156191 |
| FAT2 | FAT atypical cadherin 2 | 0.0155867 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.015506 |
| PLCE1 | phospholipase C, epsilon 1 | 0.0154595 |
| GUCY1A1 | guanylate cyclase 1 soluble subunit alpha 1 | 0.0153914 |
| APOL1 | apolipoprotein L, 1 | 0.0153484 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0153419 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0152961 |
| EXOC4 | exocyst complex component 4 | 0.0151782 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0150279 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.207431 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0970395 |
| NDRG1 | N-myc downstream regulated 1 | -0.0966394 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0812776 |
| STC1 | stanniocalcin 1 | -0.0799889 |
| FLNB | filamin B, beta | -0.0758445 |
| CD44 | CD44 molecule (Indian blood group) | -0.0726574 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0722426 |
| RAI14 | retinoic acid induced 14 | -0.0687769 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0674107 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0653369 |
| TMSB10 | thymosin beta 10 | -0.0633748 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0611054 |
| ITGA6 | integrin, alpha 6 | -0.0572083 |
| EMP1 | epithelial membrane protein 1 | -0.0546197 |
| LMO7 | LIM domain 7 | -0.0536276 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0532538 |
| MT2A | metallothionein 2A | -0.0490969 |
| MTSS1 | metastasis suppressor 1 | -0.0477784 |
| NAV2 | neuron navigator 2 | -0.0459815 |
| RPS6 | ribosomal protein S6 | -0.0434818 |
| DUSP6 | dual specificity phosphatase 6 | -0.0430372 |
| SLC35F3 | solute carrier family 35, member F3 | -0.042061 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0412436 |
| HM13 | histocompatibility (minor) 13 | -0.0399853 |
| GOLGA4 | golgin A4 | -0.0390978 |
| GNAS | GNAS complex locus | -0.0372359 |
| IGF2 | insulin-like growth factor 2 | -0.0362732 |
| HMGA2 | high mobility group AT-hook 2 | -0.0360024 |
| RASAL2 | RAS protein activator like 2 | -0.0355093 |
| RPS8 | ribosomal protein S8 | -0.034525 |
| PTMA | prothymosin, alpha | -0.0340429 |
| S100A10 | S100 calcium binding protein A10 | -0.0328955 |
| FOXP1 | forkhead box P1 | -0.032158 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0318012 |
| MYO10 | myosin X | -0.0310945 |
| EGR1 | early growth response 1 | -0.0310591 |
| PODXL | podocalyxin-like | -0.030652 |
| CDK6 | cyclin-dependent kinase 6 | -0.0304037 |
| HLA-B | major histocompatibility complex, class I, B | -0.0300188 |
| OSMR | oncostatin M receptor | -0.0298828 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0298046 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0295963 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0291742 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0289683 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0287627 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0278932 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0273964 |
| ENO1 | enolase 1, (alpha) | -0.0272135 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0271945 |
| RPS13 | ribosomal protein S13 | -0.0267883 |
| CALU | calumenin | -0.026776 |
| RPS3 | ribosomal protein S3 | -0.0267653 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.026708 |
| PALLD | palladin, cytoskeletal associated protein | -0.0265978 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0265762 |
| FOSL1 | FOS-like antigen 1 | -0.0262623 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0260505 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0259494 |
| FTL | ferritin, light polypeptide | -0.0259406 |
| TOP1 | topoisomerase (DNA) I | -0.0257308 |
| RPL35A | ribosomal protein L35a | -0.0255543 |
| MORF4L2 | mortality factor 4 like 2 | -0.0255531 |
| RPLP2 | ribosomal protein, large, P2 | -0.0255378 |
| FN1 | fibronectin 1 | -0.0253399 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0252709 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0250298 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0249831 |
| CSNK1E | casein kinase 1, epsilon | -0.0246751 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.024641 |
| DUSP4 | dual specificity phosphatase 4 | -0.0246035 |
| PRSS23 | protease, serine, 23 | -0.0244082 |
| CSTB | cystatin B (stefin B) | -0.0241634 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0241434 |
| WASF2 | WAS protein family, member 2 | -0.0240589 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0237969 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.023753 |
| RPL34 | ribosomal protein L34 | -0.0236586 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0235725 |
| SQLE | squalene epoxidase | -0.0235021 |
| RPLP1 | ribosomal protein, large, P1 | -0.02306 |
| EFNA5 | ephrin-A5 | -0.0230005 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0229475 |
| RPS25 | ribosomal protein S25 | -0.0228751 |
| CMIP | c-Maf inducing protein | -0.0228698 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0226369 |
| RPL37 | ribosomal protein L37 | -0.0221789 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0219749 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0218138 |
| RPS19 | ribosomal protein S19 | -0.0217707 |
| GLG1 | golgi glycoprotein 1 | -0.0217674 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0216157 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.021514 |
| ASPH | aspartate beta-hydroxylase | -0.02149 |
| LDHA | lactate dehydrogenase A | -0.0213027 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0212274 |
| ACTN1 | actinin, alpha 1 | -0.0211518 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0210099 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.02091 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.0208121 |
