| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.129861 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0731999 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0719836 |
| ENO1 | enolase 1, (alpha) | 0.068427 |
| ZNF841 | zinc finger protein 841 | 0.0678318 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0664475 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.059082 |
| ATP13A3 | ATPase type 13A3 | 0.0543706 |
| ADM | adrenomedullin | 0.0502957 |
| CALR | calreticulin | 0.0489927 |
| POSTN | periostin, osteoblast specific factor | 0.0487515 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0478504 |
| CANX | calnexin | 0.0476 |
| FAM120A | family with sequence similarity 120A | 0.0472038 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.046512 |
| STC2 | stanniocalcin 2 | 0.0441327 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0425403 |
| COL5A1 | collagen, type V, alpha 1 | 0.042501 |
| CCBE1 | collagen and calcium binding EGF domains 1 | 0.0415622 |
| GRAMD2B | GRAM domain containing 2B | 0.0412721 |
| GANAB | glucosidase, alpha; neutral AB | 0.0405742 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0396725 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0385522 |
| KRT18 | keratin 18, type I | 0.038429 |
| TGFB2 | transforming growth factor, beta 2 | 0.0377808 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0368812 |
| ZNF148 | zinc finger protein 148 | 0.035532 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0350048 |
| AHNAK | AHNAK nucleoprotein | 0.0343249 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.033759 |
| MYLK | myosin light chain kinase | 0.0332385 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0309441 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0308731 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0303627 |
| TPM3 | tropomyosin 3 | 0.0303397 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0296551 |
| PLCB4 | phospholipase C, beta 4 | 0.0295129 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0293652 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0289648 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0284273 |
| CAPRIN1 | cell cycle associated protein 1 | 0.028251 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0280482 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0279676 |
| DRAM1 | DNA-damage regulated autophagy modulator 1 | 0.0278759 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0278753 |
| ARRDC3 | arrestin domain containing 3 | 0.0278103 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0277094 |
| TMEM178B | transmembrane protein 178B | 0.0274957 |
| TRAM1 | translocation associated membrane protein 1 | 0.0273042 |
| PGK1 | phosphoglycerate kinase 1 | 0.0272644 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0269914 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0269428 |
| CUL4B | cullin 4B | 0.0268373 |
| BCL2L1 | BCL2-like 1 | 0.0263724 |
| SNX4 | sorting nexin 4 | 0.0261619 |
| STK4 | serine/threonine kinase 4 | 0.0259664 |
| VEGFC | vascular endothelial growth factor C | 0.0256436 |
| PLK2 | polo-like kinase 2 | 0.0250705 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.0250428 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0246075 |
| PKP4 | plakophilin 4 | 0.0244354 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0243161 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0240554 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0240404 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.023806 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0236169 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0233921 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0231144 |
| TPR | translocated promoter region, nuclear basket protein | 0.0229013 |
| ARF4 | ADP-ribosylation factor 4 | 0.022873 |
| GOLGA2 | golgin A2 | 0.0227055 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0226844 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0226559 |
| GLIS3 | GLIS family zinc finger 3 | 0.0225607 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0224691 |
| SBF2 | SET binding factor 2 | 0.0222111 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | 0.0222003 |
| KRIT1 | KRIT1, ankyrin repeat containing | 0.0221752 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | 0.0221475 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0221283 |
| MED13L | mediator complex subunit 13-like | 0.0216924 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0216207 |
| SULF1 | sulfatase 1 | 0.0213761 |
| CTTN | cortactin | 0.0212851 |
| TPM1 | tropomyosin 1 (alpha) | 0.0211993 |
| CD47 | CD47 molecule | 0.0211735 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0211716 |
| SET | SET nuclear proto-oncogene | 0.0210311 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0209336 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.0207864 |
| NCKAP1 | NCK-associated protein 1 | 0.0207373 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0207148 |
| PGM3 | phosphoglucomutase 3 | 0.0207091 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0204736 |
| CD99 | CD99 molecule | 0.0204047 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | 0.0203606 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0202148 |
| SMAD3 | SMAD family member 3 | 0.0199676 |
| CCDC14 | coiled-coil domain containing 14 | 0.0197696 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0196354 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.218366 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.192808 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.116759 |
| NDRG1 | N-myc downstream regulated 1 | -0.111335 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.103021 |
| HLA-B | major histocompatibility complex, class I, B | -0.101005 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.093913 |
| TMSB10 | thymosin beta 10 | -0.0879168 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.085524 |
| MT2A | metallothionein 2A | -0.0837701 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0687101 |
| DTNA | dystrobrevin, alpha | -0.0640324 |
| POTEF | POTE ankyrin domain family, member F | -0.0622757 |
| CCND1 | cyclin D1 | -0.0608129 |
| RPS6 | ribosomal protein S6 | -0.0594949 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0513239 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0509436 |
| ACTG1 | actin gamma 1 | -0.048804 |
| RPLP1 | ribosomal protein, large, P1 | -0.0479215 |
| RPL35A | ribosomal protein L35a | -0.0463451 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0447776 |
| ASPH | aspartate beta-hydroxylase | -0.0427516 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0421273 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0413407 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0413024 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0409374 |
| MORF4L2 | mortality factor 4 like 2 | -0.040256 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0386075 |
| HMGA1 | high mobility group AT-hook 1 | -0.0384637 |
| PKM | pyruvate kinase, muscle | -0.0384222 |
| VIM | vimentin | -0.03756 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0362352 |
| PTK2 | protein tyrosine kinase 2 | -0.0355991 |
| EGR1 | early growth response 1 | -0.0349404 |
| FTL | ferritin, light polypeptide | -0.0342153 |
| RPL31 | ribosomal protein L31 | -0.034184 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0340487 |
| RBM39 | RNA binding motif protein 39 | -0.0340412 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0334231 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0324027 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0322201 |
| NAV2 | neuron navigator 2 | -0.032185 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0316388 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0313737 |
| ERBIN | erbb2 interacting protein | -0.0313205 |
| TOP1 | topoisomerase (DNA) I | -0.0310788 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0310194 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0310016 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.030756 |
| ANXA1 | annexin A1 | -0.030456 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | -0.0304067 |
| CTSD | cathepsin D | -0.0304042 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0287167 |
| TLE4 | transducin-like enhancer of split 4 | -0.0284363 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0281393 |
| RPS24 | ribosomal protein S24 | -0.0278237 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0274278 |
| RPS20 | ribosomal protein S20 | -0.0271384 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0270914 |
| PDE8A | phosphodiesterase 8A | -0.027043 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0269625 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0266319 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0265062 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.026217 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0260241 |
| MAP4 | microtubule-associated protein 4 | -0.0259129 |
| RPL32 | ribosomal protein L32 | -0.0255677 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0251526 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0249492 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0248704 |
| SQSTM1 | sequestosome 1 | -0.0245106 |
| S100A10 | S100 calcium binding protein A10 | -0.0241872 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0240983 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0237997 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0236641 |
| HMGB1 | high mobility group box 1 | -0.0236323 |
| RPS21 | ribosomal protein S21 | -0.0236147 |
| IGF1R | insulin-like growth factor 1 receptor | -0.023046 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0230134 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0228868 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.0228773 |
| KRT17 | keratin 17, type I | -0.0226721 |
| USP34 | ubiquitin specific peptidase 34 | -0.0226631 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0224672 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0224016 |
| IPO7 | importin 7 | -0.0222285 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0221757 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0221034 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0220751 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0220317 |
| JMJD1C | jumonji domain containing 1C | -0.0219933 |
| RND3 | Rho family GTPase 3 | -0.0219114 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0218065 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0216478 |
| SP100 | SP100 nuclear antigen | -0.0216336 |
| RPLP2 | ribosomal protein, large, P2 | -0.0211408 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0210184 |
| DENND1A | DENN/MADD domain containing 1A | -0.0210017 |
| VDAC1 | voltage-dependent anion channel 1 | -0.020958 |
| LMNA | lamin A/C | -0.02091 |
