| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DSPP | dentin sialophosphoprotein | 0.104803 |
| RNF213 | ring finger protein 213 | 0.0742409 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0706675 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0690614 |
| KRT17 | keratin 17, type I | 0.0654395 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0613992 |
| HYOU1 | hypoxia up-regulated 1 | 0.0608147 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0600503 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0575028 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0532516 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.051139 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0464645 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.044943 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0448978 |
| AHR | aryl hydrocarbon receptor | 0.0442417 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0440129 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0423547 |
| PRSS3 | protease, serine, 3 | 0.0412243 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.040716 |
| GOLGB1 | golgin B1 | 0.0399835 |
| TJP1 | tight junction protein 1 | 0.0381611 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0371032 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0367833 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0362277 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0362092 |
| STK24 | serine/threonine kinase 24 | 0.0354197 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0345922 |
| MYOF | myoferlin | 0.0340394 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0336304 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0335112 |
| PRELID2 | PRELI domain containing 2 | 0.0332824 |
| ATXN1 | ataxin 1 | 0.0321727 |
| TRIM2 | tripartite motif containing 2 | 0.0319445 |
| CALR | calreticulin | 0.0313173 |
| TMEM45B | transmembrane protein 45B | 0.0311674 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0308252 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0303509 |
| ALPK1 | alpha-kinase 1 | 0.0293957 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.028358 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.027561 |
| TRIM31 | tripartite motif containing 31 | 0.0273304 |
| MGAM2 | maltase-glucoamylase 2 (putative) | 0.0270002 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.026938 |
| EXOC6B | exocyst complex component 6B | 0.0268577 |
| COG5 | component of oligomeric golgi complex 5 | 0.026417 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.026212 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0260956 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0256395 |
| EZR | ezrin | 0.0253831 |
| SEC24D | SEC24 family member D | 0.0252544 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0249378 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0247332 |
| PGM3 | phosphoglucomutase 3 | 0.0247103 |
| COG6 | component of oligomeric golgi complex 6 | 0.0245217 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0244985 |
| DNAJB11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | 0.0239804 |
| RUNX1 | runt-related transcription factor 1 | 0.0239396 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0239037 |
| ANXA11 | annexin A11 | 0.0238785 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0238501 |
| MECOM | MDS1 and EVI1 complex locus | 0.0235118 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0234757 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0230761 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0229744 |
| MUC13 | mucin 13, cell surface associated | 0.0228409 |
| SHROOM3 | shroom family member 3 | 0.0227272 |
| NBAS | neuroblastoma amplified sequence | 0.0227215 |
| TES | testin LIM domain protein | 0.0227005 |
| AHNAK | AHNAK nucleoprotein | 0.0224792 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0224044 |
| ERP44 | endoplasmic reticulum protein 44 | 0.0221941 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0220773 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0219664 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0219625 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0218514 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0216117 |
| IRF1 | interferon regulatory factor 1 | 0.021609 |
| NEK7 | NIMA-related kinase 7 | 0.0214527 |
| SLFN5 | schlafen family member 5 | 0.0213786 |
| FNDC3A | fibronectin type III domain containing 3A | 0.021262 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0211572 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0210947 |
| KRT19 | keratin 19, type I | 0.0210134 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.0209665 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0207539 |
| CLINT1 | clathrin interactor 1 | 0.0206479 |
| RBM39 | RNA binding motif protein 39 | 0.0205331 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0204528 |
| SEC23B | Sec23 homolog B (S. cerevisiae) | 0.0202292 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0202242 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0201955 |
| MAGT1 | magnesium transporter 1 | 0.0201085 |
| BRD2 | bromodomain containing 2 | 0.0200913 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0199684 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.0197666 |
| MUC4 | mucin 4, cell surface associated | 0.0196951 |
| PCBP2 | poly(rC) binding protein 2 | 0.0196928 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0194302 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0193969 |
| GOLGA4 | golgin A4 | 0.0193803 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.235713 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.21147 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.179421 |
| TMSB10 | thymosin beta 10 | -0.178083 |
| NPSR1 | neuropeptide S receptor 1 | -0.132673 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.118918 |
| FAT1 | FAT atypical cadherin 1 | -0.117359 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.110678 |
| PTMA | prothymosin, alpha | -0.109591 |
| CDK6 | cyclin-dependent kinase 6 | -0.0988337 |
| EHBP1 | EH domain binding protein 1 | -0.0950101 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0904844 |
| ITGA6 | integrin, alpha 6 | -0.0894284 |
| ASPH | aspartate beta-hydroxylase | -0.0877313 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0864563 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0844849 |
| S100A6 | S100 calcium binding protein A6 | -0.0784387 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0778085 |
| RPS6 | ribosomal protein S6 | -0.0768709 |
| FLNB | filamin B, beta | -0.0760994 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0676961 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0644226 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0635657 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0629251 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.059477 |
| KRT18 | keratin 18, type I | -0.0583944 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0579932 |
| PGK1 | phosphoglycerate kinase 1 | -0.057849 |
| ANXA2 | annexin A2 | -0.0564864 |
| TMC5 | transmembrane channel-like 5 | -0.0552432 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0529872 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0512547 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0507852 |
| RPL35A | ribosomal protein L35a | -0.0490251 |
| EMP1 | epithelial membrane protein 1 | -0.0474804 |
| RPL23 | ribosomal protein L23 | -0.0474757 |
| BCL2L1 | BCL2-like 1 | -0.0456146 |
| ITGB4 | integrin, beta 4 | -0.0445479 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0445121 |
| LCN2 | lipocalin 2 | -0.0442376 |
| S100A10 | S100 calcium binding protein A10 | -0.0435797 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0433319 |
| WWC1 | WW and C2 domain containing 1 | -0.0428784 |
| CCND1 | cyclin D1 | -0.0424609 |
| DEK | DEK proto-oncogene | -0.0410358 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0407087 |
| PKM | pyruvate kinase, muscle | -0.0404488 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0394992 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0391239 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0385133 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.036975 |
| ATF5 | activating transcription factor 5 | -0.036826 |
| TMEM123 | transmembrane protein 123 | -0.0367188 |
| RPL26 | ribosomal protein L26 | -0.0363998 |
| AUTS2 | autism susceptibility candidate 2 | -0.0357759 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0356198 |
| SULF2 | sulfatase 2 | -0.0351376 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0345606 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0343039 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0342161 |
| ENO1 | enolase 1, (alpha) | -0.0339235 |
| FTL | ferritin, light polypeptide | -0.0338123 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0337835 |
| RPS19 | ribosomal protein S19 | -0.0336409 |
| KRT8 | keratin 8, type II | -0.0331718 |
| YAP1 | Yes-associated protein 1 | -0.0330875 |
| LMO7 | LIM domain 7 | -0.0328914 |
| ONECUT3 | one cut homeobox 3 | -0.0326688 |
| AGR2 | anterior gradient 2 | -0.0325877 |
| RPLP1 | ribosomal protein, large, P1 | -0.0323065 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0320813 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0319109 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.031829 |
| TPM4 | tropomyosin 4 | -0.0312512 |
| RPS8 | ribosomal protein S8 | -0.0312201 |
| RPL36A | ribosomal protein L36a | -0.0311713 |
| AOPEP | aminopeptidase O (putative) | -0.031006 |
| LRP5 | low density lipoprotein receptor-related protein 5 | -0.0303972 |
| S100A11 | S100 calcium binding protein A11 | -0.0301582 |
| LMNA | lamin A/C | -0.030121 |
| HMGB1 | high mobility group box 1 | -0.0300198 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0293258 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0291259 |
| RPS16 | ribosomal protein S16 | -0.0286515 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0284468 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0283102 |
| SET | SET nuclear proto-oncogene | -0.0280059 |
| RPS21 | ribosomal protein S21 | -0.0278788 |
| RPS24 | ribosomal protein S24 | -0.0278559 |
| RNF43 | ring finger protein 43 | -0.0277711 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -0.0276088 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0275005 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0271541 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0271112 |
| RPS3 | ribosomal protein S3 | -0.0270605 |
| HMGA1 | high mobility group AT-hook 1 | -0.0268646 |
| RAI1 | retinoic acid induced 1 | -0.0266472 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.026646 |
| MED13 | mediator complex subunit 13 | -0.0264512 |
| ABHD2 | abhydrolase domain containing 2 | -0.0262177 |
