| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in LOX-IMVI cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD109 | CD109 molecule | 0.0742046 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0420668 |
| ZNF292 | zinc finger protein 292 | 0.0392257 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0385842 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0373845 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0361344 |
| NUP58 | nucleoporin 58 | 0.0337157 |
| ARRDC3 | arrestin domain containing 3 | 0.0333251 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0311936 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0300042 |
| ADM | adrenomedullin | 0.029765 |
| CASC3 | cancer susceptibility candidate 3 | 0.0286522 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.027203 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0252551 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0247558 |
| YTHDC1 | YTH domain containing 1 | 0.023942 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0236048 |
| DTNA | dystrobrevin, alpha | 0.0226882 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0223465 |
| OGA | O-GlcNAcase | 0.020997 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0206598 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.020192 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0200458 |
| WDR45B | WD repeat domain 45B | 0.0191397 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0183416 |
| SPAG9 | sperm associated antigen 9 | 0.0179652 |
| CDK19 | cyclin-dependent kinase 19 | 0.0177903 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0175027 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0174495 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0173115 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0171246 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0169771 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0168759 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0166872 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0162531 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0161604 |
| RPS2 | ribosomal protein S2 | 0.0159112 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0157191 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0156187 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0152656 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0151699 |
| RAB21 | RAB21, member RAS oncogene family | 0.0150563 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0146788 |
| INSIG2 | insulin induced gene 2 | 0.0145126 |
| COLEC11 | collectin sub-family member 11 | 0.0142935 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0141639 |
| CD47 | CD47 molecule | 0.0139417 |
| ZNF395 | zinc finger protein 395 | 0.0137635 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0137014 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0136677 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.013516 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0131304 |
| MT1X | metallothionein 1X | 0.0127778 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0126542 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.012568 |
| TXNL1 | thioredoxin-like 1 | 0.0124528 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0123247 |
| UBE2Q2 | ubiquitin-conjugating enzyme E2Q family member 2 | 0.0122768 |
| HDAC3 | histone deacetylase 3 | 0.0122368 |
| SMAD3 | SMAD family member 3 | 0.012101 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0120267 |
| TPM2 | tropomyosin 2 (beta) | 0.0119939 |
| TRIM33 | tripartite motif containing 33 | 0.011982 |
| ATP13A3 | ATPase type 13A3 | 0.011754 |
| PPP4R2 | protein phosphatase 4, regulatory subunit 2 | 0.0116525 |
| SERINC1 | serine incorporator 1 | 0.0114602 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0113954 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.0113151 |
| CDC73 | cell division cycle 73 | 0.0111997 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.0109562 |
| CEP85L | centrosomal protein 85kDa-like | 0.0108544 |
| MED15 | mediator complex subunit 15 | 0.0108135 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0107406 |
| GANAB | glucosidase, alpha; neutral AB | 0.0106279 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0105078 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0104978 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0104764 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0104434 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0103072 |
| FAT4 | FAT atypical cadherin 4 | 0.0102236 |
| HDGF | hepatoma-derived growth factor | 0.0101458 |
| RNF145 | ring finger protein 145 | 0.0101245 |
| MYO1B | myosin IB | 0.0100859 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.00985764 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.00982051 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0097779 |
| CENPC | centromere protein C | 0.00966539 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.00945883 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.00943038 |
| LRRC8C | leucine rich repeat containing 8 family, member C | 0.00940341 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.00939727 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.00930508 |
| KDM2B | lysine (K)-specific demethylase 2B | 0.00929818 |
| RAB18 | RAB18, member RAS oncogene family | 0.00916182 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00911855 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | 0.00910017 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.00901634 |
| ANKRD30A | ankyrin repeat domain 30A | 0.00900141 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.00898326 |
| NCKAP1 | NCK-associated protein 1 | 0.00894853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.216166 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.20962 |
| TMSB10 | thymosin beta 10 | -0.201028 |
| EXT1 | exostosin glycosyltransferase 1 | -0.128147 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0974656 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0919686 |
| ASPH | aspartate beta-hydroxylase | -0.0891808 |
| VCL | vinculin | -0.0771208 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0737552 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0724936 |
| RPL23 | ribosomal protein L23 | -0.0708241 |
| CALD1 | caldesmon 1 | -0.0701183 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0693966 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.069147 |
| RPLP1 | ribosomal protein, large, P1 | -0.068444 |
| CD44 | CD44 molecule (Indian blood group) | -0.0672937 |
| CDK6 | cyclin-dependent kinase 6 | -0.0659528 |
| RTN4 | reticulon 4 | -0.0659214 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0655392 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0650013 |
| PKM | pyruvate kinase, muscle | -0.0614406 |
| UBC | ubiquitin C | -0.0577789 |
| AHNAK | AHNAK nucleoprotein | -0.0575038 |
| RPS6 | ribosomal protein S6 | -0.0559453 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.055367 |
| RPS27A | ribosomal protein S27a | -0.0542083 |
| MT2A | metallothionein 2A | -0.0533025 |
| ACTG1 | actin gamma 1 | -0.052537 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0524228 |
| EGR1 | early growth response 1 | -0.0517485 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0501664 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.049562 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0493558 |
| USP34 | ubiquitin specific peptidase 34 | -0.0480071 |
| MYO10 | myosin X | -0.0474152 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0468992 |
| RPL31 | ribosomal protein L31 | -0.0455904 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0449537 |
| HDAC9 | histone deacetylase 9 | -0.0448877 |
| FTL | ferritin, light polypeptide | -0.0446774 |
| PTMA | prothymosin, alpha | -0.0441476 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0437927 |
| KYNU | kynureninase | -0.0430515 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0427196 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0425918 |
| TNNC1 | troponin C type 1 (slow) | -0.0411869 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0406239 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0401982 |
| JMJD1C | jumonji domain containing 1C | -0.0401691 |
| RND3 | Rho family GTPase 3 | -0.0400046 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0398917 |
| POTEF | POTE ankyrin domain family, member F | -0.0396289 |
| ERBIN | erbb2 interacting protein | -0.0395583 |
| RPLP2 | ribosomal protein, large, P2 | -0.0389422 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0387446 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0384617 |
| LSAMP | limbic system-associated membrane protein | -0.0383323 |
| NABP1 | nucleic acid binding protein 1 | -0.0383251 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.038295 |
| PTK2 | protein tyrosine kinase 2 | -0.0380736 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0373612 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0373279 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0366738 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0366051 |
| ENO1 | enolase 1, (alpha) | -0.0364946 |
| HMGA1 | high mobility group AT-hook 1 | -0.0364533 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0362711 |
| KIAA1549L | KIAA1549-like | -0.03586 |
| TXNRD1 | thioredoxin reductase 1 | -0.0357083 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0355085 |
| NAV3 | neuron navigator 3 | -0.0348049 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0346925 |
| MCL1 | myeloid cell leukemia 1 | -0.0346393 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0345414 |
| FN1 | fibronectin 1 | -0.033988 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0338448 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0336234 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0334578 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0332665 |
| FRMD6 | FERM domain containing 6 | -0.0332398 |
| RPS19 | ribosomal protein S19 | -0.0331941 |
| MAP1B | microtubule-associated protein 1B | -0.0331662 |
| LIMA1 | LIM domain and actin binding 1 | -0.0330035 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0329743 |
| PTCHD4 | patched domain containing 4 | -0.0329479 |
| EGFR | epidermal growth factor receptor | -0.0329314 |
| LDHA | lactate dehydrogenase A | -0.0328695 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0326257 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0321399 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0321235 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0319193 |
| CDH13 | cadherin 13 | -0.0318838 |
| TMPRSS15 | transmembrane protease, serine 15 | -0.0309227 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0308332 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0306762 |
| RPS24 | ribosomal protein S24 | -0.0304444 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0303403 |
| NAV1 | neuron navigator 1 | -0.0303164 |
| BPTF | bromodomain PHD finger transcription factor | -0.030217 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0301136 |
