| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.168405 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.125543 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.122462 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.114618 |
| DSPP | dentin sialophosphoprotein | 0.0943904 |
| PRELID2 | PRELI domain containing 2 | 0.0853068 |
| EREG | epiregulin | 0.0842624 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0777894 |
| MUC13 | mucin 13, cell surface associated | 0.0772543 |
| SHROOM3 | shroom family member 3 | 0.0763373 |
| GOLGA4 | golgin A4 | 0.0658028 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.063082 |
| FAM13A | family with sequence similarity 13, member A | 0.0618961 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0603485 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0599579 |
| GPHN | gephyrin | 0.0594391 |
| AHNAK | AHNAK nucleoprotein | 0.0585377 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.055319 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.054375 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0539348 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | 0.0537069 |
| OGA | O-GlcNAcase | 0.0524998 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0521373 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0514689 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0510906 |
| PTEN | phosphatase and tensin homolog | 0.0495404 |
| INSIG1 | insulin induced gene 1 | 0.0486286 |
| EPCAM | epithelial cell adhesion molecule | 0.048541 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0484998 |
| TRIM2 | tripartite motif containing 2 | 0.0484056 |
| PIGR | polymeric immunoglobulin receptor | 0.0474808 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0472276 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0461336 |
| NRXN3 | neurexin 3 | 0.0460933 |
| ANKRD11 | ankyrin repeat domain 11 | 0.045912 |
| ZNF292 | zinc finger protein 292 | 0.0454524 |
| FOXP1 | forkhead box P1 | 0.0447444 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0442958 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0441444 |
| RNF43 | ring finger protein 43 | 0.0435859 |
| RBM39 | RNA binding motif protein 39 | 0.0435361 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0432091 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0431272 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.042978 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0427646 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0426303 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0421463 |
| CANX | calnexin | 0.041838 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0417359 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0415051 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0414554 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0413305 |
| CDK19 | cyclin-dependent kinase 19 | 0.0407383 |
| CALR | calreticulin | 0.0404816 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0399045 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.039407 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0392807 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0390775 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.039027 |
| MECOM | MDS1 and EVI1 complex locus | 0.0389701 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0388446 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0386432 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0383635 |
| FNBP1L | formin binding protein 1-like | 0.0381936 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0380184 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0377508 |
| GSK3B | glycogen synthase kinase 3 beta | 0.037728 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0377081 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0376537 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0372316 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0367636 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0366865 |
| CDC42SE2 | CDC42 small effector 2 | 0.0364419 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0364245 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0363226 |
| ATXN1 | ataxin 1 | 0.0361154 |
| PDZD8 | PDZ domain containing 8 | 0.0360641 |
| MYO10 | myosin X | 0.0355709 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0352413 |
| CERS6 | ceramide synthase 6 | 0.0351441 |
| DENND4C | DENN/MADD domain containing 4C | 0.0349264 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0345252 |
| CLTC | clathrin, heavy chain (Hc) | 0.0343955 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0343833 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0340029 |
| MYO1D | myosin ID | 0.0339687 |
| GLCE | glucuronic acid epimerase | 0.0338767 |
| COG5 | component of oligomeric golgi complex 5 | 0.0338016 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0335984 |
| KITLG | KIT ligand | 0.0335028 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0333092 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0332785 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0330058 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0329068 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0327994 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0325624 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0325615 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0322291 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0320395 |
| EHF | ets homologous factor | 0.0319908 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.140482 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.139722 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0993625 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0888757 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0875862 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0828689 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0772248 |
| TNS4 | tensin 4 | -0.0712043 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0706714 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0683711 |
| TPM4 | tropomyosin 4 | -0.0656224 |
| ONECUT3 | one cut homeobox 3 | -0.0647194 |
| FLNB | filamin B, beta | -0.0622966 |
| ASPH | aspartate beta-hydroxylase | -0.0600695 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0571031 |
| MT2A | metallothionein 2A | -0.0554255 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0522447 |
| ANXA2 | annexin A2 | -0.0505392 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.048177 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0478126 |
| KRT18 | keratin 18, type I | -0.0467759 |
| LMO7 | LIM domain 7 | -0.0466844 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0463891 |
| FAT1 | FAT atypical cadherin 1 | -0.0453815 |
| LAMA4 | laminin, alpha 4 | -0.0450889 |
| POTEF | POTE ankyrin domain family, member F | -0.0449948 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0428956 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0398427 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0392589 |
| ITGB4 | integrin, beta 4 | -0.0380744 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0376042 |
| SH3D19 | SH3 domain containing 19 | -0.0365303 |
| RNF217 | ring finger protein 217 | -0.0363704 |
| FERMT1 | fermitin family member 1 | -0.0362799 |
| PKM | pyruvate kinase, muscle | -0.0358544 |
| ACTG1 | actin gamma 1 | -0.0353199 |
| FOSL1 | FOS-like antigen 1 | -0.0351902 |
| ABHD2 | abhydrolase domain containing 2 | -0.0349968 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0348529 |
| RPS6 | ribosomal protein S6 | -0.0346145 |
| EGFR | epidermal growth factor receptor | -0.0339538 |
| S100A6 | S100 calcium binding protein A6 | -0.0334737 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0334032 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0327309 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0323205 |
| FTL | ferritin, light polypeptide | -0.032158 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0320419 |
| EZR | ezrin | -0.0317605 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0313938 |
| TFF1 | trefoil factor 1 | -0.0306337 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0294851 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0289385 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | -0.0287061 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0280578 |
| HMGA1 | high mobility group AT-hook 1 | -0.0279909 |
| EGR1 | early growth response 1 | -0.0265307 |
| ITGA6 | integrin, alpha 6 | -0.0263762 |
| MUC17 | mucin 17, cell surface associated | -0.026017 |
| CALB1 | calbindin 1, 28kDa | -0.0259648 |
| MT1X | metallothionein 1X | -0.0258315 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | -0.0256251 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0249275 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0245793 |
| CADPS | Ca++-dependent secretion activator | -0.0243558 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0242828 |
| IER3 | immediate early response 3 | -0.0241363 |
| KLK10 | kallikrein-related peptidase 10 | -0.0240495 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0240311 |
| CCND1 | cyclin D1 | -0.0239546 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0238519 |
| LAMC2 | laminin, gamma 2 | -0.0236783 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0235279 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0232141 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.023015 |
| NPSR1 | neuropeptide S receptor 1 | -0.0229241 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0226961 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0225235 |
| LMNA | lamin A/C | -0.0221193 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0215838 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0215054 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0213431 |
| EHBP1 | EH domain binding protein 1 | -0.0207965 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0207312 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.020635 |
| VCAN | versican | -0.0206018 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0204612 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0203914 |
| EMP1 | epithelial membrane protein 1 | -0.0202186 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0200907 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0200873 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0198806 |
| CSTB | cystatin B (stefin B) | -0.0196502 |
| NDRG1 | N-myc downstream regulated 1 | -0.0191845 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0186249 |
| EFNB2 | ephrin-B2 | -0.0184134 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0183971 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0182176 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0181693 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0181452 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0181401 |
