| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.168703 |
| PRELID2 | PRELI domain containing 2 | 0.155532 |
| RAD51B | RAD51 paralog B | 0.069092 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0686743 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0650027 |
| GOLGA4 | golgin A4 | 0.0600577 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.059623 |
| ZNF292 | zinc finger protein 292 | 0.059018 |
| PDE8A | phosphodiesterase 8A | 0.0577423 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0574894 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0570755 |
| NRXN3 | neurexin 3 | 0.0534283 |
| ETV6 | ets variant 6 | 0.0514338 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0500905 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0496722 |
| CDK19 | cyclin-dependent kinase 19 | 0.0485108 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0482454 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0479015 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0468558 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0467666 |
| RPS12 | ribosomal protein S12 | 0.0458637 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0444843 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0442792 |
| CDC42SE2 | CDC42 small effector 2 | 0.0438931 |
| MUC13 | mucin 13, cell surface associated | 0.0429793 |
| CCPG1 | cell cycle progression 1 | 0.0410952 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0406536 |
| PTEN | phosphatase and tensin homolog | 0.0404529 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.039642 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0393671 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.0382451 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0380642 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0373133 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0372246 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0371049 |
| TSPAN8 | tetraspanin 8 | 0.0370565 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0365699 |
| SHROOM3 | shroom family member 3 | 0.0361077 |
| KIF16B | kinesin family member 16B | 0.0358996 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0358694 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0357721 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0356885 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0355678 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0349804 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.034955 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0347206 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0346125 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0341904 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0340858 |
| NEBL | nebulette | 0.0340481 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0334374 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0333406 |
| DENND4C | DENN/MADD domain containing 4C | 0.0332831 |
| WWC1 | WW and C2 domain containing 1 | 0.0329583 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0329481 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0326505 |
| MED13L | mediator complex subunit 13-like | 0.0323456 |
| FAM13A | family with sequence similarity 13, member A | 0.0321912 |
| MX1 | MX dynamin-like GTPase 1 | 0.0317038 |
| OGA | O-GlcNAcase | 0.0315029 |
| SMYD3 | SET and MYND domain containing 3 | 0.0314392 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0308343 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0307675 |
| PCBP2 | poly(rC) binding protein 2 | 0.0307487 |
| WWOX | WW domain containing oxidoreductase | 0.0304983 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0304832 |
| CLIC5 | chloride intracellular channel 5 | 0.0302081 |
| ATXN1 | ataxin 1 | 0.0299875 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0293001 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0292492 |
| PLAC8 | placenta-specific 8 | 0.02921 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0286563 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0286293 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0286019 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0283922 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0283147 |
| MEF2C | myocyte enhancer factor 2C | 0.0282783 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0279622 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0276751 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0276487 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0274279 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0273891 |
| MYO1D | myosin ID | 0.0273131 |
| FNIP1 | folliculin interacting protein 1 | 0.0271839 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0269387 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0268879 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.0267761 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0267345 |
| SBF2 | SET binding factor 2 | 0.0266284 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | 0.0264032 |
| RNF213 | ring finger protein 213 | 0.0263709 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0260991 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0259078 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0257626 |
| ZZEF1 | zinc finger, ZZ-type with EF-hand domain 1 | 0.0256962 |
| METTL15 | methyltransferase like 15 | 0.0256907 |
| LOC105378220 | macrophage receptor MARCO-like | 0.0256708 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0256074 |
| YEATS2 | YEATS domain containing 2 | 0.0253999 |
| NKTR | natural killer cell triggering receptor | 0.0252997 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.199287 |
| LMO7 | LIM domain 7 | -0.149388 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.140185 |
| FLNB | filamin B, beta | -0.13416 |
| ANXA2 | annexin A2 | -0.132133 |
| MSI2 | musashi RNA-binding protein 2 | -0.124415 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.116156 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.109556 |
| TMSB10 | thymosin beta 10 | -0.104658 |
| ACTG1 | actin gamma 1 | -0.0848069 |
| EZR | ezrin | -0.0842109 |
| PKM | pyruvate kinase, muscle | -0.0728825 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0719054 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0665179 |
| RPLP1 | ribosomal protein, large, P1 | -0.0647868 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0630995 |
| ITGA6 | integrin, alpha 6 | -0.0611946 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0563207 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0556471 |
| MYOF | myoferlin | -0.0554996 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0538903 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.053883 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0527634 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0521534 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0515804 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0492986 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0491049 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0490312 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0473002 |
| SPON1 | spondin 1, extracellular matrix protein | -0.0412736 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0405272 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0405105 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0401022 |
| PCDHB16 | protocadherin beta 16 | -0.0399103 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0395628 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0385592 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0374389 |
| EGFR | epidermal growth factor receptor | -0.0369437 |
| RPL4 | ribosomal protein L4 | -0.0366658 |
| OXSR1 | oxidative stress responsive 1 | -0.0365576 |
| KRT18 | keratin 18, type I | -0.0362429 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0358393 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0348709 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.034067 |
| LAMA4 | laminin, alpha 4 | -0.0339128 |
| SLTM | SAFB-like, transcription modulator | -0.0336009 |
| S100A10 | S100 calcium binding protein A10 | -0.0334776 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0334734 |
| EGR1 | early growth response 1 | -0.0333505 |
| ASPH | aspartate beta-hydroxylase | -0.0325676 |
| PRSS3 | protease, serine, 3 | -0.0320739 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0320622 |
| FERMT1 | fermitin family member 1 | -0.0316119 |
| FOXO1 | forkhead box O1 | -0.0311274 |
| RPLP0 | ribosomal protein, large, P0 | -0.0310713 |
| MYO1E | myosin IE | -0.030971 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | -0.0308559 |
| ITGB4 | integrin, beta 4 | -0.0306172 |
| KRT8 | keratin 8, type II | -0.0304935 |
| RPS24 | ribosomal protein S24 | -0.0301695 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0298525 |
| ACTN4 | actinin, alpha 4 | -0.02952 |
| POTEF | POTE ankyrin domain family, member F | -0.0293915 |
| SH3D19 | SH3 domain containing 19 | -0.0293534 |
| TJP1 | tight junction protein 1 | -0.0291679 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.028343 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0275037 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.027038 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0270231 |
| LAMB3 | laminin, beta 3 | -0.0262786 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0260914 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0258449 |
| PERP | PERP, TP53 apoptosis effector | -0.0257958 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.025389 |
| EMP1 | epithelial membrane protein 1 | -0.0251463 |
| CCND1 | cyclin D1 | -0.0250311 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0246841 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0245993 |
| CTBP2 | C-terminal binding protein 2 | -0.0243718 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0242871 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0242751 |
| FBXO11 | F-box protein 11 | -0.0242685 |
| CLDN4 | claudin 4 | -0.0242117 |
| RPL32 | ribosomal protein L32 | -0.0241315 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0232325 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0229876 |
| RBM25 | RNA binding motif protein 25 | -0.0227093 |
| HMGA1 | high mobility group AT-hook 1 | -0.022647 |
| MYO5B | myosin VB | -0.0225378 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0223643 |
| COBL | cordon-bleu WH2 repeat protein | -0.0222503 |
| DSG3 | desmoglein 3 | -0.0221843 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0221009 |
| MTAP | methylthioadenosine phosphorylase | -0.0216847 |
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 | -0.0213382 |
| FOSL1 | FOS-like antigen 1 | -0.0210646 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.020946 |
| CALB1 | calbindin 1, 28kDa | -0.0208755 |
| RACK1 | receptor for activated C kinase 1 | -0.0208252 |
| EPHA2 | EPH receptor A2 | -0.0207029 |
