| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.10151 |
| DST | dystonin | 0.0909181 |
| COL5A2 | collagen, type V, alpha 2 | 0.0810127 |
| ANXA1 | annexin A1 | 0.0560114 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0543697 |
| CFB | complement factor B | 0.0520989 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0390987 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.038619 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0383577 |
| ZNF292 | zinc finger protein 292 | 0.0382018 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0373143 |
| SPAG9 | sperm associated antigen 9 | 0.0371714 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0356311 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0344895 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0343766 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0338024 |
| EPHA4 | EPH receptor A4 | 0.0335188 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0329075 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.032126 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.031977 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0313278 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0312975 |
| EGFR | epidermal growth factor receptor | 0.03067 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0303295 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0300996 |
| B2M | beta-2-microglobulin | 0.0295464 |
| ADAR | adenosine deaminase, RNA-specific | 0.0283716 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0265006 |
| GOLGA4 | golgin A4 | 0.0264736 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0262132 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0256006 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0248952 |
| ARRDC3 | arrestin domain containing 3 | 0.0246171 |
| HELZ | helicase with zinc finger | 0.0243402 |
| FAM13A | family with sequence similarity 13, member A | 0.0237043 |
| MB21D2 | Mab-21 domain containing 2 | 0.0236293 |
| CD109 | CD109 molecule | 0.0230906 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0228801 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0228603 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0225635 |
| TNS3 | tensin 3 | 0.0225018 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0224101 |
| CALR | calreticulin | 0.0223366 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0215506 |
| SFTPA2 | surfactant protein A2 | 0.0215485 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0209902 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0208198 |
| WTAP | Wilms tumor 1 associated protein | 0.0207456 |
| PHF21A | PHD finger protein 21A | 0.0206826 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0205377 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0205062 |
| QKI | QKI, KH domain containing, RNA binding | 0.0204764 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0203579 |
| KLHL24 | kelch-like family member 24 | 0.0199681 |
| CDC73 | cell division cycle 73 | 0.0197714 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0197517 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0195963 |
| OGA | O-GlcNAcase | 0.0194604 |
| BRINP3 | bone morphogenetic protein/retinoic acid inducible neural-specific 3 | 0.0194575 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0192882 |
| OPTN | optineurin | 0.0192525 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0192305 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0191891 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0191777 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0190235 |
| ANLN | anillin, actin binding protein | 0.0189211 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0183938 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0182501 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0181963 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0181323 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0179663 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0179431 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0179073 |
| CLIC4 | chloride intracellular channel 4 | 0.0178751 |
| CDK19 | cyclin-dependent kinase 19 | 0.0176943 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0173585 |
| CUL4B | cullin 4B | 0.0172781 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.017129 |
| TMEM123 | transmembrane protein 123 | 0.0171121 |
| LMNA | lamin A/C | 0.01702 |
| TRERF1 | transcriptional regulating factor 1 | 0.016736 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0167116 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0166533 |
| FAM162A | family with sequence similarity 162, member A | 0.0165892 |
| RNF213 | ring finger protein 213 | 0.0165531 |
| FNIP1 | folliculin interacting protein 1 | 0.0163932 |
| SQSTM1 | sequestosome 1 | 0.0161557 |
| NEK7 | NIMA-related kinase 7 | 0.0161015 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.016059 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0159389 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0156803 |
| RBM39 | RNA binding motif protein 39 | 0.0156105 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0155078 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0153538 |
| PGK1 | phosphoglycerate kinase 1 | 0.0153362 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0152449 |
| SRP54 | signal recognition particle 54kDa | 0.015123 |
| PER1 | period circadian clock 1 | 0.015084 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0149159 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0149141 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.213387 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.164615 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.162499 |
| CD44 | CD44 molecule (Indian blood group) | -0.157897 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.126651 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.120359 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.118746 |
| TMSB10 | thymosin beta 10 | -0.111224 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.106258 |
| MT2A | metallothionein 2A | -0.099272 |
| TXNRD1 | thioredoxin reductase 1 | -0.0957139 |
| CAPRIN2 | caprin family member 2 | -0.0952545 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0935485 |
| FMNL2 | formin-like 2 | -0.090241 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0880549 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0878909 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0848138 |
| RAI1 | retinoic acid induced 1 | -0.0841242 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0774104 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0744718 |
| PDE10A | phosphodiesterase 10A | -0.0738143 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0688492 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0675438 |
| CMIP | c-Maf inducing protein | -0.0647185 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0637416 |
| APP | amyloid beta (A4) precursor protein | -0.0636058 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0625991 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0609821 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0604801 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0591154 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0588072 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0578 |
| TSC22D1 | TSC22 domain family, member 1 | -0.057185 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0570843 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.057036 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0569465 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0564109 |
| EGR1 | early growth response 1 | -0.0559134 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0558911 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0556376 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.054711 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0537659 |
| FLNB | filamin B, beta | -0.0517058 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0515706 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0514361 |
| POTEF | POTE ankyrin domain family, member F | -0.0513736 |
| JUN | jun proto-oncogene | -0.049552 |
| UBC | ubiquitin C | -0.0465933 |
| EZR | ezrin | -0.0465645 |
| EHBP1 | EH domain binding protein 1 | -0.046102 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.045765 |
| TOP1 | topoisomerase (DNA) I | -0.0436597 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0432494 |
| ACTG1 | actin gamma 1 | -0.0425857 |
| HMGA1 | high mobility group AT-hook 1 | -0.0419879 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0418035 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0415554 |
| PYGL | phosphorylase, glycogen, liver | -0.041393 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.04048 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0393615 |
| NAV2 | neuron navigator 2 | -0.038577 |
| EREG | epiregulin | -0.0384287 |
| VMP1 | vacuole membrane protein 1 | -0.0383563 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0378534 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0377436 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0375537 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.037468 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0374655 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0374501 |
| CDK6 | cyclin-dependent kinase 6 | -0.0372057 |
| USP34 | ubiquitin specific peptidase 34 | -0.0363439 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.0355449 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0347467 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0338189 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0337653 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.033727 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0336737 |
| UPP1 | uridine phosphorylase 1 | -0.0336021 |
| HDAC9 | histone deacetylase 9 | -0.0335841 |
| FBXO11 | F-box protein 11 | -0.0335725 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.033267 |
| EMP1 | epithelial membrane protein 1 | -0.0324257 |
| PTMA | prothymosin, alpha | -0.0320077 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0319443 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0318885 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0318037 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0317395 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0316613 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0316506 |
| MCL1 | myeloid cell leukemia 1 | -0.0316051 |
| LOXL2 | lysyl oxidase-like 2 | -0.0315441 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.0313963 |
| RGS4 | regulator of G-protein signaling 4 | -0.0312205 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0310172 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0309106 |
| DENND1A | DENN/MADD domain containing 1A | -0.030816 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0307759 |
| PTK2 | protein tyrosine kinase 2 | -0.0304818 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0303968 |
| BMERB1 | bMERB domain containing 1 | -0.0303461 |
