| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.310714 |
| FAM13A | family with sequence similarity 13, member A | 0.136044 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0987561 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0730927 |
| TXNRD1 | thioredoxin reductase 1 | 0.0725648 |
| NGLY1 | N-glycanase 1 | 0.0723448 |
| ARRDC3 | arrestin domain containing 3 | 0.0718061 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0703298 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.068673 |
| OGA | O-GlcNAcase | 0.0546869 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.054199 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.047841 |
| TPD52 | tumor protein D52 | 0.0468181 |
| ZNF292 | zinc finger protein 292 | 0.0455906 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.044416 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0439143 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0420404 |
| CES1 | carboxylesterase 1 | 0.0412818 |
| HELZ | helicase with zinc finger | 0.040412 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0402271 |
| PDE8A | phosphodiesterase 8A | 0.0401762 |
| TMEM165 | transmembrane protein 165 | 0.0390544 |
| NDRG1 | N-myc downstream regulated 1 | 0.03882 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0359401 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0355754 |
| WDR45B | WD repeat domain 45B | 0.0353741 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0353338 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0350427 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0349497 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0348849 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0321991 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0321564 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0320594 |
| BBX | bobby sox homolog (Drosophila) | 0.0308749 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.030602 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0304469 |
| RNF145 | ring finger protein 145 | 0.0304151 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0297012 |
| SPAG9 | sperm associated antigen 9 | 0.0295644 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0285475 |
| SRP54 | signal recognition particle 54kDa | 0.0284989 |
| SUCO | SUN domain containing ossification factor | 0.0283503 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0283473 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0280476 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0277174 |
| YEATS2 | YEATS domain containing 2 | 0.027499 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0272917 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0272396 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0267044 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0266573 |
| PCBP2 | poly(rC) binding protein 2 | 0.0265107 |
| NPTN | neuroplastin | 0.0263816 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0263619 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0259204 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0255529 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0254303 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0252611 |
| CANX | calnexin | 0.0249715 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0248096 |
| NCKAP1 | NCK-associated protein 1 | 0.0241869 |
| HYOU1 | hypoxia up-regulated 1 | 0.0239449 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0237224 |
| RAB6A | RAB6A, member RAS oncogene family | 0.023352 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0230343 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0229234 |
| ZFR | zinc finger RNA binding protein | 0.022771 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0226356 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.022572 |
| MKI67 | marker of proliferation Ki-67 | 0.0225245 |
| YTHDC1 | YTH domain containing 1 | 0.0225137 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.022228 |
| INSIG2 | insulin induced gene 2 | 0.0222217 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0221058 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.021642 |
| PRELID2 | PRELI domain containing 2 | 0.021452 |
| PGK1 | phosphoglycerate kinase 1 | 0.0213349 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0213185 |
| PAPOLA | poly(A) polymerase alpha | 0.021238 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.0209482 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0206308 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0204332 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0203855 |
| ATG14 | autophagy related 14 | 0.0203336 |
| FNIP1 | folliculin interacting protein 1 | 0.0203189 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0202147 |
| ZNF638 | zinc finger protein 638 | 0.0201866 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.020112 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0198507 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.019764 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0195667 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0195019 |
| JAK1 | Janus kinase 1 | 0.019486 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0194281 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0194275 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0191251 |
| ZNF654 | zinc finger protein 654 | 0.0189553 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0189419 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0189186 |
| CDC73 | cell division cycle 73 | 0.0188581 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0188149 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.181043 |
| EGFR | epidermal growth factor receptor | -0.165453 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.132534 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.132489 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.124668 |
| ASPH | aspartate beta-hydroxylase | -0.122292 |
| ACTG1 | actin gamma 1 | -0.115539 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.114971 |
| MCL1 | myeloid cell leukemia 1 | -0.108161 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.104577 |
| EGR1 | early growth response 1 | -0.10218 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.100202 |
| LAMC2 | laminin, gamma 2 | -0.0985864 |
| S100A10 | S100 calcium binding protein A10 | -0.091902 |
| LMO7 | LIM domain 7 | -0.0901535 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0767955 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0760671 |
| STC1 | stanniocalcin 1 | -0.0756537 |
| EFNA5 | ephrin-A5 | -0.0735988 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0724247 |
| PTMA | prothymosin, alpha | -0.0686288 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.067415 |
| INTS6 | integrator complex subunit 6 | -0.0672921 |
| MYO1E | myosin IE | -0.0670007 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0661732 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0629682 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0606319 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0597601 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.058807 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0576601 |
| PKM | pyruvate kinase, muscle | -0.057406 |
| VCL | vinculin | -0.0566218 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0544457 |
| CST3 | cystatin C | -0.0538276 |
| NABP1 | nucleic acid binding protein 1 | -0.0520172 |
| AREG | amphiregulin | -0.0512522 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0511985 |
| SLTM | SAFB-like, transcription modulator | -0.0504583 |
| OSMR | oncostatin M receptor | -0.0497255 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0492213 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0489644 |
| MT2A | metallothionein 2A | -0.0488617 |
| LAMA4 | laminin, alpha 4 | -0.048131 |
| SCEL | sciellin | -0.0466027 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0444779 |
| SP100 | SP100 nuclear antigen | -0.0442036 |
| CCND1 | cyclin D1 | -0.0437934 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0431855 |
| KRT7 | keratin 7, type II | -0.0429888 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.042639 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0424303 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0423999 |
| TPM4 | tropomyosin 4 | -0.0420818 |
| MYO1D | myosin ID | -0.0420028 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0410079 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.040815 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0405186 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0392519 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0388122 |
| HLA-B | major histocompatibility complex, class I, B | -0.0383283 |
| KRT18 | keratin 18, type I | -0.0383151 |
| RPS24 | ribosomal protein S24 | -0.0382876 |
| CUX1 | cut-like homeobox 1 | -0.0377792 |
| ANXA2 | annexin A2 | -0.0373096 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0369725 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0368075 |
| IER3 | immediate early response 3 | -0.0364941 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0364613 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0362266 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0354674 |
| FBXO11 | F-box protein 11 | -0.0353883 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0349852 |
| TOP1 | topoisomerase (DNA) I | -0.0348472 |
| PRKCA | protein kinase C, alpha | -0.0346371 |
| KRT8 | keratin 8, type II | -0.0343879 |
| RPLP1 | ribosomal protein, large, P1 | -0.0342797 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0337529 |
| S100A11 | S100 calcium binding protein A11 | -0.0336272 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0334038 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0331923 |
| RPL35A | ribosomal protein L35a | -0.0331835 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.033016 |
| RPL31 | ribosomal protein L31 | -0.0327781 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0325555 |
| FOXP1 | forkhead box P1 | -0.0314 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0310238 |
| EZR | ezrin | -0.0308522 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0299648 |
| GRAMD1B | GRAM domain containing 1B | -0.0293277 |
| LDHA | lactate dehydrogenase A | -0.0292616 |
| RNF213 | ring finger protein 213 | -0.0291225 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0286182 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0285823 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0285728 |
| HOMER1 | homer scaffolding protein 1 | -0.0284293 |
| CMIP | c-Maf inducing protein | -0.0280934 |
| ATG7 | autophagy related 7 | -0.0280678 |
| CDCP1 | CUB domain containing protein 1 | -0.0279594 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0277865 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0277219 |
