| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.143129 |
| FAM13A | family with sequence similarity 13, member A | 0.110129 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0756685 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0629866 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0561907 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.054842 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0541739 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0452313 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0450473 |
| MEF2A | myocyte enhancer factor 2A | 0.0446684 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0439539 |
| RUNX2 | runt-related transcription factor 2 | 0.0430841 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0425502 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0411275 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0411035 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0397977 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0393746 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.039074 |
| ADM | adrenomedullin | 0.0388221 |
| FBN1 | fibrillin 1 | 0.0376488 |
| ZNF292 | zinc finger protein 292 | 0.0371389 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0363084 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0358491 |
| GPC6 | glypican 6 | 0.0334552 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0328705 |
| PRELID2 | PRELI domain containing 2 | 0.0313502 |
| NGLY1 | N-glycanase 1 | 0.031059 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0308534 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0306924 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0306916 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0302099 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.030084 |
| ANXA1 | annexin A1 | 0.0297486 |
| CA12 | carbonic anhydrase XII | 0.0295764 |
| MYOF | myoferlin | 0.0295218 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0290489 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0290342 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0288334 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0286515 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0279285 |
| B2M | beta-2-microglobulin | 0.0268614 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0266859 |
| CFB | complement factor B | 0.0260454 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0259319 |
| ADAR | adenosine deaminase, RNA-specific | 0.0256274 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0253575 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0252788 |
| ARRDC3 | arrestin domain containing 3 | 0.024582 |
| JAK1 | Janus kinase 1 | 0.0244462 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0243918 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0243168 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0240159 |
| FBXO32 | F-box protein 32 | 0.023943 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0238161 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0237185 |
| OPTN | optineurin | 0.0236853 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0236404 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0233207 |
| RARB | retinoic acid receptor, beta | 0.022872 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0224428 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0224038 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.022301 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 0.0221284 |
| WTAP | Wilms tumor 1 associated protein | 0.0220994 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0220296 |
| KIF13A | kinesin family member 13A | 0.0219555 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0219394 |
| RBM39 | RNA binding motif protein 39 | 0.021901 |
| PGK1 | phosphoglycerate kinase 1 | 0.0217719 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.021754 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0216008 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0215398 |
| PHF21A | PHD finger protein 21A | 0.0214984 |
| MAP4 | microtubule-associated protein 4 | 0.0212107 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0210246 |
| DIO2 | deiodinase, iodothyronine, type II | 0.0210208 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0208536 |
| ZCCHC2 | zinc finger, CCHC domain containing 2 | 0.0208498 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0208291 |
| OGA | O-GlcNAcase | 0.0208116 |
| ANK2 | ankyrin 2, neuronal | 0.0206202 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0203609 |
| RPL35A | ribosomal protein L35a | 0.0203275 |
| QKI | QKI, KH domain containing, RNA binding | 0.0202758 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0199179 |
| RNF213 | ring finger protein 213 | 0.0198833 |
| SQSTM1 | sequestosome 1 | 0.019535 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.019519 |
| RIOK3 | RIO kinase 3 | 0.0194951 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0194052 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.0193384 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0193243 |
| MX1 | MX dynamin-like GTPase 1 | 0.0193169 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0191684 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0190621 |
| HMCN1 | hemicentin 1 | 0.019033 |
| DCLK2 | doublecortin-like kinase 2 | 0.018942 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0188854 |
| MXI1 | MAX interactor 1, dimerization protein | 0.018787 |
| MCC | mutated in colorectal cancers | 0.0186585 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | -0.306874 |
| EFNA5 | ephrin-A5 | -0.184995 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.160342 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.15314 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.145235 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.114016 |
| HMGA2 | high mobility group AT-hook 2 | -0.11375 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.113224 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.106192 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.103245 |
| GLCCI1 | glucocorticoid induced 1 | -0.09367 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0906379 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0869677 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0866586 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0849652 |
| STC1 | stanniocalcin 1 | -0.0835679 |
| CDH13 | cadherin 13 | -0.0784977 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.075507 |
| NRP1 | neuropilin 1 | -0.0754684 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0744289 |
| VIM | vimentin | -0.0739422 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0728223 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0722685 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.070217 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0700705 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0700541 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0697149 |
| OSMR | oncostatin M receptor | -0.0689503 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0678041 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0654634 |
| MCL1 | myeloid cell leukemia 1 | -0.0630694 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0615801 |
| TMSB10 | thymosin beta 10 | -0.0603158 |
| NPC1 | Niemann-Pick disease, type C1 | -0.059869 |
| CDCP1 | CUB domain containing protein 1 | -0.0596367 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0595282 |
| TGM2 | transglutaminase 2 | -0.0588484 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0584477 |
| MT2A | metallothionein 2A | -0.0579792 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0576205 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.056711 |
| FAM107B | family with sequence similarity 107, member B | -0.0548734 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0530484 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0527466 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0526658 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0526378 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0521201 |
| EGR1 | early growth response 1 | -0.0513736 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0511056 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0474594 |
| ECE1 | endothelin converting enzyme 1 | -0.0471721 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0468039 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0446447 |
| LOX | lysyl oxidase | -0.0444499 |
| UBC | ubiquitin C | -0.0432342 |
| VMP1 | vacuole membrane protein 1 | -0.0429675 |
| ANKRD28 | ankyrin repeat domain 28 | -0.042364 |
| TOP1 | topoisomerase (DNA) I | -0.0417156 |
| NTN4 | netrin 4 | -0.0413931 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0413578 |
| SMAD3 | SMAD family member 3 | -0.041112 |
| STK38L | serine/threonine kinase 38 like | -0.0409786 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0407275 |
| HAS2 | hyaluronan synthase 2 | -0.0406213 |
| SYAP1 | synapse associated protein 1 | -0.0403412 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0403085 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0389979 |
| MEIS1 | Meis homeobox 1 | -0.0379459 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0379237 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0376349 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.037605 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0374391 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0369718 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0367527 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0362465 |
| MYO10 | myosin X | -0.0361417 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0359275 |
| VCL | vinculin | -0.0353184 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0348179 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.034644 |
| KSR1 | kinase suppressor of ras 1 | -0.034318 |
| EGFR | epidermal growth factor receptor | -0.0334281 |
| IL1R1 | interleukin 1 receptor, type I | -0.0323723 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0322629 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0320385 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0319065 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0318115 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0318013 |
| DUSP5 | dual specificity phosphatase 5 | -0.0317384 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.031044 |
| TUT7 | terminal uridylyl transferase 7 | -0.0309554 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0298524 |
| TNNC1 | troponin C type 1 (slow) | -0.0298142 |
| COPA | coatomer protein complex, subunit alpha | -0.0293567 |
| PKM | pyruvate kinase, muscle | -0.0293022 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0292491 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0287915 |
| LUZP1 | leucine zipper protein 1 | -0.0286483 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0282286 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0280634 |
