Trametinib (DMSO_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib (DMSO perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib (DMSO_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.186985
FGB fibrinogen beta chain 0.178866
PDE4D phosphodiesterase 4D, cAMP-specific 0.0817168
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0800165
TPM3 tropomyosin 3 0.0793691
RPS12 ribosomal protein S12 0.0770079
FGG fibrinogen gamma chain 0.0752235
FGA fibrinogen alpha chain 0.0747155
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0743131
PTMA prothymosin, alpha 0.0713037
BASP1 brain abundant, membrane attached signal protein 1 0.0712583
CALR calreticulin 0.0641256
VIM vimentin 0.0611527
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0536474
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.053355
TPT1 tumor protein, translationally-controlled 1 0.0522186
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0517115
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0511775
NAP1L1 nucleosome assembly protein 1-like 1 0.0478004
RPS8 ribosomal protein S8 0.0458227
EEF2 eukaryotic translation elongation factor 2 0.0456378
EIF1 eukaryotic translation initiation factor 1 0.0439093
LPP LIM domain containing preferred translocation partner in lipoma 0.0430111
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0425284
RPS29 ribosomal protein S29 0.0425208
ZNF292 zinc finger protein 292 0.0424317
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0413875
APLP2 amyloid beta (A4) precursor-like protein 2 0.0409271
RPL19 ribosomal protein L19 0.0400723
KIAA0319 KIAA0319 0.0386955
RPL37A ribosomal protein L37a 0.0383883
KMT2E lysine (K)-specific methyltransferase 2E 0.037833
ENO1 enolase 1, (alpha) 0.0377123
AHNAK AHNAK nucleoprotein 0.0376249
HDGF hepatoma-derived growth factor 0.0370291
RPL7 ribosomal protein L7 0.0369732
CANX calnexin 0.0365514
LMNA lamin A/C 0.0351659
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0339175
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0337853
NTM neurotrimin 0.0333741
RPS21 ribosomal protein S21 0.0332612
RPS3 ribosomal protein S3 0.032705
KTN1 kinectin 1 (kinesin receptor) 0.0319547
PCBP2 poly(rC) binding protein 2 0.0317106
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0312961
RPL23 ribosomal protein L23 0.0310389
MYH9 myosin, heavy chain 9, non-muscle 0.0307503
SERINC1 serine incorporator 1 0.0306421
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0302176
RPS2 ribosomal protein S2 0.0296356
B2M beta-2-microglobulin 0.0294617
RPS27A ribosomal protein S27a 0.028811
WWOX WW domain containing oxidoreductase 0.0281779
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.028127
RPL5 ribosomal protein L5 0.0280339
EEF1G eukaryotic translation elongation factor 1 gamma 0.0273736
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0270705
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0265357
ASPH aspartate beta-hydroxylase 0.0262192
PABPN1 poly(A) binding protein, nuclear 1 0.0261498
GANAB glucosidase, alpha; neutral AB 0.0261261
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0259414
MACF1 microtubule-actin crosslinking factor 1 0.0258756
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0256007
RPL12 ribosomal protein L12 0.0250957
PRR16 proline rich 16 0.0248566
CBX5 chromobox homolog 5 0.02479
S100A9 S100 calcium binding protein A9 0.0247277
NPTN neuroplastin 0.0246115
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0245419
YBX1 Y box binding protein 1 0.0244732
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0242651
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0242439
RPS27 ribosomal protein S27 0.0240262
ENAH enabled homolog (Drosophila) 0.0239559
SERF2 small EDRK-rich factor 2 0.0239267
IQGAP1 IQ motif containing GTPase activating protein 1 0.0235654
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0235465
LDHB lactate dehydrogenase B 0.0234207
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0233643
BMP5 bone morphogenetic protein 5 0.0231375
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.022892
CFAP73 cilia and flagella associated protein 73 0.0228803
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0228517
RPL13A ribosomal protein L13a 0.0227662
SFTPA2 surfactant protein A2 0.0227001
FXR1 fragile X mental retardation, autosomal homolog 1 0.0226021
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0225724
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0223497
DEK DEK proto-oncogene 0.0223197
ANXA1 annexin A1 0.0223069
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0222107
NNMT nicotinamide N-methyltransferase 0.0221044
RPS10 ribosomal protein S10 0.0219903
SARNP SAP domain containing ribonucleoprotein 0.0216138
NFIA nuclear factor I/A 0.0215936
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0213846
EIF4B eukaryotic translation initiation factor 4B 0.0212918
RPS17 ribosomal protein S17 0.0211311

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.240103
MT2A metallothionein 2A -0.218949
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.145912
DOCK4 dedicator of cytokinesis 4 -0.121366
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.112567
TMSB10 thymosin beta 10 -0.105697
THSD4 thrombospondin, type I, domain containing 4 -0.105645
MCL1 myeloid cell leukemia 1 -0.101163
TM4SF1 transmembrane 4 L six family member 1 -0.0958775
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0884635
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0881385
IGF2 insulin-like growth factor 2 -0.0875949
EGR1 early growth response 1 -0.0875603
TXNRD1 thioredoxin reductase 1 -0.0698774
STC1 stanniocalcin 1 -0.0641015
PDLIM5 PDZ and LIM domain 5 -0.0611602
IER3 immediate early response 3 -0.0609886
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0594478
NAV3 neuron navigator 3 -0.058996
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0580947
AKAP12 A kinase (PRKA) anchor protein 12 -0.0566413
UBASH3B ubiquitin associated and SH3 domain containing B -0.055564
SLC38A2 solute carrier family 38, member 2 -0.0535517
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0529654
HDAC9 histone deacetylase 9 -0.0516256
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0507013
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0500963
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0493303
FAM107B family with sequence similarity 107, member B -0.0486052
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0474641
NRG1 neuregulin 1 -0.0473605
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0465555
ELL2 elongation factor, RNA polymerase II, 2 -0.0458166
LOC102724023 ES1 protein homolog, mitochondrial -0.0451092
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0447633
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0440675
AGO2 argonaute RISC catalytic component 2 -0.0437503
USP34 ubiquitin specific peptidase 34 -0.0433856
DENND4A DENN/MADD domain containing 4A -0.0433756
OSMR oncostatin M receptor -0.0427676
FMNL2 formin-like 2 -0.0424247
RAB7A RAB7A, member RAS oncogene family -0.0398322
SVIL supervillin -0.0392505
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0388561
GLIS3 GLIS family zinc finger 3 -0.0383238
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.038246
MAML3 mastermind-like 3 (Drosophila) -0.0352955
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0340248
NABP1 nucleic acid binding protein 1 -0.0334162
RPTOR regulatory associated protein of MTOR, complex 1 -0.0321933
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0320534
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0316734
PTK2 protein tyrosine kinase 2 -0.0315623
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0307115
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0306688
TOP1 topoisomerase (DNA) I -0.030565
NHSL1 NHS-like 1 -0.0304097
KYNU kynureninase -0.0300561
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0300471
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0298977
VMP1 vacuole membrane protein 1 -0.029638
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0292135
DOCK5 dedicator of cytokinesis 5 -0.0288961
BMP6 bone morphogenetic protein 6 -0.0287069
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0284054
MARCHF4 membrane associated ring-CH-type finger 4 -0.0282462
POTEF POTE ankyrin domain family, member F -0.0278573
SLC38A1 solute carrier family 38, member 1 -0.0276525
RASAL2 RAS protein activator like 2 -0.0276409
ACTN1 actinin, alpha 1 -0.0271879
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0262582
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0256238
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0254997
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0254092
CDCP1 CUB domain containing protein 1 -0.02529
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0252191
MAPK8 mitogen-activated protein kinase 8 -0.0248501
GLS2 glutaminase 2 (liver, mitochondrial) -0.0248364
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0247706
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0247594
WDR43 WD repeat domain 43 -0.0239428
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0238872
NPC1 Niemann-Pick disease, type C1 -0.0235017
FLNB filamin B, beta -0.0232619
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0231923
TMEM131 transmembrane protein 131 -0.0228638
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0227019
RBM39 RNA binding motif protein 39 -0.0226897
RPL4 ribosomal protein L4 -0.0225618
RUNX1 runt-related transcription factor 1 -0.022489
BRD2 bromodomain containing 2 -0.0223679
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0222536
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0221798
EXT1 exostosin glycosyltransferase 1 -0.0216533
AK1 adenylate kinase 1 -0.0215607
BICD1 bicaudal D homolog 1 (Drosophila) -0.0214542
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.021418
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0213753
INHBA inhibin, beta A -0.02136
COPA coatomer protein complex, subunit alpha -0.02124