Trametinib (DMSO_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib (DMSO perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib (DMSO_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0847683
RAB1A RAB1A, member RAS oncogene family 0.0814024
MYH9 myosin, heavy chain 9, non-muscle 0.0714494
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0636108
SPAG9 sperm associated antigen 9 0.0612684
RPS6 ribosomal protein S6 0.0610789
FMNL2 formin-like 2 0.0605855
DSPP dentin sialophosphoprotein 0.0605682
WAC WW domain containing adaptor with coiled-coil 0.0558846
CLASP1 cytoplasmic linker associated protein 1 0.0542007
TTC3 tetratricopeptide repeat domain 3 0.0541536
AKAP12 A kinase (PRKA) anchor protein 12 0.054076
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0529749
FLNB filamin B, beta 0.0527542
GPC6 glypican 6 0.0523004
OGA O-GlcNAcase 0.0510251
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.050835
VIM vimentin 0.0495343
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0488698
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0474923
CANX calnexin 0.0470623
USP3 ubiquitin specific peptidase 3 0.0460307
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0453846
ANXA1 annexin A1 0.0451805
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0450271
AHNAK AHNAK nucleoprotein 0.0435584
EEF2 eukaryotic translation elongation factor 2 0.0432297
DST dystonin 0.0426791
CALR calreticulin 0.0426651
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0419983
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0411734
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0411704
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0411148
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0405498
ANXA2 annexin A2 0.0396431
RBM39 RNA binding motif protein 39 0.0396359
PDLIM5 PDZ and LIM domain 5 0.0395338
SET SET nuclear proto-oncogene 0.0392487
QKI QKI, KH domain containing, RNA binding 0.0383927
TXNIP thioredoxin interacting protein 0.0378978
PUM2 pumilio RNA-binding family member 2 0.0374017
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0361116
RTN4 reticulon 4 0.0357323
PTMA prothymosin, alpha 0.0355935
RASAL2 RAS protein activator like 2 0.0354457
PAPOLA poly(A) polymerase alpha 0.0353729
CSNK1A1 casein kinase 1, alpha 1 0.0350462
FUS FUS RNA binding protein 0.0350026
PPHLN1 periphilin 1 0.0348268
PTGES2 prostaglandin E synthase 2 0.0345607
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0344474
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0340191
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0338948
GARS1 glycyl-tRNA synthetase 1 0.0337771
EGFR epidermal growth factor receptor 0.0335441
FNDC3A fibronectin type III domain containing 3A 0.0329973
MKI67 marker of proliferation Ki-67 0.0329819
ENAH enabled homolog (Drosophila) 0.0329413
NAMPT nicotinamide phosphoribosyltransferase 0.0328523
ZFAND3 zinc finger, AN1-type domain 3 0.0326826
FAM13A family with sequence similarity 13, member A 0.0325528
OSBPL8 oxysterol binding protein-like 8 0.032387
HMGA2 high mobility group AT-hook 2 0.0322455
TRIO trio Rho guanine nucleotide exchange factor 0.0319808
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0318473
KMT2E lysine (K)-specific methyltransferase 2E 0.0317318
LMTK2 lemur tyrosine kinase 2 0.0317026
KIF13A kinesin family member 13A 0.0313863
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0307985
APP amyloid beta (A4) precursor protein 0.0302938
ZNF654 zinc finger protein 654 0.0301876
RPL11 ribosomal protein L11 0.0297399
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0295338
COL6A3 collagen, type VI, alpha 3 0.0292169
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0292065
DUSP16 dual specificity phosphatase 16 0.0290063
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0289744
PTBP2 polypyrimidine tract binding protein 2 0.02883
ACTG1 actin gamma 1 0.0287865
RHOA ras homolog family member A 0.028776
SCAF8 SR-related CTD-associated factor 8 0.0287102
SFTPA2 surfactant protein A2 0.0284662
CUX1 cut-like homeobox 1 0.0284163
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0283457
FMR1 fragile X mental retardation 1 0.028281
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0280077
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0279569
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0278562
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0276882
SOD2 superoxide dismutase 2, mitochondrial 0.0276034
SENP6 SUMO1/sentrin specific peptidase 6 0.0275762
CHD1 chromodomain helicase DNA binding protein 1 0.0275404
ZEB1 zinc finger E-box binding homeobox 1 0.0273947
WDFY2 WD repeat and FYVE domain containing 2 0.0273872
USP9X ubiquitin specific peptidase 9, X-linked 0.0272994
COG5 component of oligomeric golgi complex 5 0.0270117
MAML2 mastermind-like 2 (Drosophila) 0.0269197
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0269168
ERRFI1 ERBB receptor feedback inhibitor 1 0.0267028
RAP1B RAP1B, member of RAS oncogene family 0.0265543

decreased expression

Symbol Name Standardized Value
LAMC2 laminin, gamma 2 -0.115767
GRB10 growth factor receptor-bound protein 10 -0.108058
MUC16 mucin 16, cell surface associated -0.0978602
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0958031
CEMIP cell migration inducing protein, hyaluronan binding -0.090061
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0859952
AKAP13 A kinase (PRKA) anchor protein 13 -0.0701358
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0674799
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0659066
RCOR1 REST corepressor 1 -0.0642067
ANTXR2 anthrax toxin receptor 2 -0.058932
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.058652
LMO7 LIM domain 7 -0.0558787
ESYT2 extended synaptotagmin-like protein 2 -0.055556
SPNS2 spinster homolog 2 (Drosophila) -0.0538702
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0529876
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0524673
KIF13B kinesin family member 13B -0.0515851
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0503394
ABHD17C abhydrolase domain containing 17C -0.0503053
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0502346
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0499715
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0487684
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0472415
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0467376
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0461611
ATOSA atos homolog A -0.0455234
BIRC6 baculoviral IAP repeat containing 6 -0.0454456
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0443419
TGFA transforming growth factor, alpha -0.0437099
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0422718
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0419662
CATSPERB catsper channel auxiliary subunit beta -0.0419521
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0415684
TMPRSS4 transmembrane protease, serine 4 -0.0414995
ACTN4 actinin, alpha 4 -0.0413805
FOSL2 FOS-like antigen 2 -0.0412909
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0407755
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0404468
ZNF185 zinc finger protein 185 (LIM domain) -0.0400149
OSMR oncostatin M receptor -0.039856
BACE2 beta-site APP-cleaving enzyme 2 -0.0396223
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.039466
MYO1E myosin IE -0.0389232
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0387235
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0380128
AKAP9 A kinase (PRKA) anchor protein 9 -0.0378417
KDM7A lysine (K)-specific demethylase 7A -0.0375123
SNRK SNF related kinase -0.0371903
SHB Src homology 2 domain containing adaptor protein B -0.0371574
BAIAP2L1 BAI1-associated protein 2-like 1 -0.036917
SOX4 SRY (sex determining region Y)-box 4 -0.0361962
MRPS6 mitochondrial ribosomal protein S6 -0.0356977
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0356295
DLG1 discs, large homolog 1 (Drosophila) -0.0356259
TMEM165 transmembrane protein 165 -0.035551
STEAP4 STEAP family member 4 -0.0342754
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0341903
RSAD2 radical S-adenosyl methionine domain containing 2 -0.034139
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0339495
AK1 adenylate kinase 1 -0.0335656
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0328695
KYNU kynureninase -0.0327906
ARHGAP21 Rho GTPase activating protein 21 -0.0327692
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0326643
RBM47 RNA binding motif protein 47 -0.0325644
ADAM10 ADAM metallopeptidase domain 10 -0.0324403
LIPH lipase, member H -0.0322761
TMCC3 transmembrane and coiled-coil domain family 3 -0.032159
SMOC1 SPARC related modular calcium binding 1 -0.0319478
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0318567
ITPRID2 ITPR interacting domain containing 2 -0.0315427
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.03135
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0312358
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0310611
RREB1 ras responsive element binding protein 1 -0.0309605
PLSCR1 phospholipid scramblase 1 -0.0308949
MCL1 myeloid cell leukemia 1 -0.030889
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0308277
BTBD9 BTB (POZ) domain containing 9 -0.0306635
MUC13 mucin 13, cell surface associated -0.0305296
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0305022
SCEL sciellin -0.030168
ARHGAP32 Rho GTPase activating protein 32 -0.0301076
S100A9 S100 calcium binding protein A9 -0.0300907
SRRM2 serine/arginine repetitive matrix 2 -0.0300386
JARID2 jumonji, AT rich interactive domain 2 -0.0299365
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0298025
KDM6A lysine (K)-specific demethylase 6A -0.0297308
ZNF638 zinc finger protein 638 -0.0296406
CARD11 caspase recruitment domain family, member 11 -0.0295961
SUMF1 sulfatase modifying factor 1 -0.0295461
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0293867
SBF2 SET binding factor 2 -0.0291965
HLA-A major histocompatibility complex, class I, A -0.029148
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0290051
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0289593
ZNF217 zinc finger protein 217 -0.0288721
SPDYA speedy/RINGO cell cycle regulator family member A -0.0287278
ANKRD36C ankyrin repeat domain 36C -0.0285073