| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RAD51B | RAD51 paralog B | 0.109701 |
| PDE10A | phosphodiesterase 10A | 0.0675814 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.057252 |
| WWOX | WW domain containing oxidoreductase | 0.049623 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0463084 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0457064 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0449778 |
| ADAR | adenosine deaminase, RNA-specific | 0.0439395 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0437334 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0436149 |
| PRELID2 | PRELI domain containing 2 | 0.0434917 |
| MED13L | mediator complex subunit 13-like | 0.042222 |
| ANKRD36B | ankyrin repeat domain 36B | 0.0419673 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0400747 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0382556 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0381288 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0370677 |
| BMP5 | bone morphogenetic protein 5 | 0.0363275 |
| SMYD3 | SET and MYND domain containing 3 | 0.0350242 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0347358 |
| CEP250 | centrosomal protein 250kDa | 0.0329763 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0304097 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0301704 |
| RNF213 | ring finger protein 213 | 0.0300485 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0289835 |
| CENPF | centromere protein F, 350/400kDa | 0.0285492 |
| CBX5 | chromobox homolog 5 | 0.0281545 |
| OGA | O-GlcNAcase | 0.0277174 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0275775 |
| ARRDC3 | arrestin domain containing 3 | 0.027395 |
| EXOC4 | exocyst complex component 4 | 0.0273162 |
| ENO1 | enolase 1, (alpha) | 0.0268278 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0262934 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0261312 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.026042 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0257573 |
| PCBP2 | poly(rC) binding protein 2 | 0.0255037 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0253685 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0253632 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0253248 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0245876 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0245362 |
| MACROD2 | MACRO domain containing 2 | 0.0244658 |
| ZNF292 | zinc finger protein 292 | 0.0242649 |
| BBX | bobby sox homolog (Drosophila) | 0.0240772 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0238128 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0237654 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 0.0235297 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0231536 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0228588 |
| ATG10 | autophagy related 10 | 0.022333 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0220001 |
| UTRN | utrophin | 0.021896 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0218371 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0217887 |
| CEP70 | centrosomal protein 70kDa | 0.0217867 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0216409 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0215679 |
| CUL4B | cullin 4B | 0.0214844 |
| SSH2 | slingshot protein phosphatase 2 | 0.0212741 |
| COL5A2 | collagen, type V, alpha 2 | 0.0211237 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0210632 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0208423 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0208205 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0206606 |
| ATXN1 | ataxin 1 | 0.0206605 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0205759 |
| DSPP | dentin sialophosphoprotein | 0.0204211 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0203486 |
| PHF21A | PHD finger protein 21A | 0.0201077 |
| FAM13A | family with sequence similarity 13, member A | 0.0198797 |
| XPO1 | exportin 1 | 0.0195828 |
| LMNA | lamin A/C | 0.0195617 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0194754 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0194511 |
| CDK19 | cyclin-dependent kinase 19 | 0.0193579 |
| KIF13A | kinesin family member 13A | 0.0193222 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0189567 |
| TENM3 | teneurin transmembrane protein 3 | 0.0188424 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0188153 |
| EXOC6B | exocyst complex component 6B | 0.0185813 |
| MSI2 | musashi RNA-binding protein 2 | 0.0185651 |
| PHF3 | PHD finger protein 3 | 0.0184949 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0184482 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0184323 |
| AEBP2 | AE binding protein 2 | 0.01821 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0179058 |
| PREPL | prolyl endopeptidase-like | 0.0179046 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.0177716 |
| PRKD1 | protein kinase D1 | 0.0175451 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0174589 |
| CEP192 | centrosomal protein 192kDa | 0.0172322 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0170477 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | 0.0169027 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0167466 |
| MTERF1 | mitochondrial transcription termination factor 1 | 0.0166572 |
| CEP112 | centrosomal protein 112kDa | 0.0166262 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0165887 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0165571 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0163192 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.447184 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.247131 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.141379 |
| EGR1 | early growth response 1 | -0.1205 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.110538 |
| MCL1 | myeloid cell leukemia 1 | -0.0953299 |
| GRAMD1B | GRAM domain containing 1B | -0.0903604 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0846682 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0832775 |
| TMSB10 | thymosin beta 10 | -0.0803334 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0743507 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0734604 |
| ACTG1 | actin gamma 1 | -0.0683648 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0652496 |
| YBX3 | Y box binding protein 3 | -0.0651211 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.063866 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0617474 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0566478 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0559324 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0546657 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0522849 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0519425 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0512525 |
| VIM | vimentin | -0.0512322 |
| NABP1 | nucleic acid binding protein 1 | -0.0503902 |
| STC1 | stanniocalcin 1 | -0.0486756 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0484352 |
| FMNL2 | formin-like 2 | -0.0447359 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.043927 |
| NF1 | neurofibromin 1 | -0.0430398 |
| JMJD1C | jumonji domain containing 1C | -0.0429021 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0427824 |
| CDK17 | cyclin-dependent kinase 17 | -0.0426493 |
| ACTN1 | actinin, alpha 1 | -0.0416708 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0413989 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0412584 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.040796 |
| KRT18 | keratin 18, type I | -0.0401305 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0379959 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0377223 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0370708 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0370209 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0369272 |
| AFF3 | AF4/FMR2 family, member 3 | -0.036181 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0359888 |
| MORF4L2 | mortality factor 4 like 2 | -0.0358217 |
| POTEF | POTE ankyrin domain family, member F | -0.0353693 |
| PFN1 | profilin 1 | -0.0349147 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0347703 |
| VMP1 | vacuole membrane protein 1 | -0.0346546 |
| DOCK5 | dedicator of cytokinesis 5 | -0.034445 |
| HMGA2 | high mobility group AT-hook 2 | -0.0342156 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0334613 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0323592 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0321067 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0319323 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0319092 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0315821 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0313545 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0313277 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0312505 |
| E2F3 | E2F transcription factor 3 | -0.0307191 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0303182 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0302891 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0301139 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0298577 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0298303 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.029683 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0296518 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0291029 |
| RRM2 | ribonucleotide reductase M2 | -0.0289826 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0287876 |
| RPLP1 | ribosomal protein, large, P1 | -0.0287507 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0285928 |
| OSMR | oncostatin M receptor | -0.02837 |
| VCL | vinculin | -0.0283658 |
| MMP12 | matrix metallopeptidase 12 | -0.0282617 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0280598 |
| CDCP1 | CUB domain containing protein 1 | -0.0276205 |
| CCND1 | cyclin D1 | -0.0274769 |
| SRPK1 | SRSF protein kinase 1 | -0.0274182 |
| ATP13A3 | ATPase type 13A3 | -0.0272966 |
| RTN4 | reticulon 4 | -0.0270413 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0267889 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0266216 |
| ATP11A | ATPase, class VI, type 11A | -0.0265499 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0263847 |
| IPO7 | importin 7 | -0.0261313 |
| UBC | ubiquitin C | -0.0260138 |
| SETX | senataxin | -0.0259779 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0258564 |
| COPA | coatomer protein complex, subunit alpha | -0.0258314 |
| IGF2 | insulin-like growth factor 2 | -0.0257478 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0256837 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0256183 |
| STK4 | serine/threonine kinase 4 | -0.0256048 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0255694 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0255096 |
| IER3 | immediate early response 3 | -0.0254158 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0252798 |
