| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.212253 |
| PTMA | prothymosin, alpha | 0.189541 |
| FN1 | fibronectin 1 | 0.158065 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.101215 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.100949 |
| CALR | calreticulin | 0.0879584 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0833393 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0825618 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0760697 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0753144 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0741555 |
| DSPP | dentin sialophosphoprotein | 0.0726278 |
| CANX | calnexin | 0.0725246 |
| FBXO32 | F-box protein 32 | 0.0661305 |
| ENO1 | enolase 1, (alpha) | 0.0656392 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0637929 |
| FAM13A | family with sequence similarity 13, member A | 0.0626024 |
| HMGB2 | high mobility group box 2 | 0.0622813 |
| CD47 | CD47 molecule | 0.0610877 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0602918 |
| PCBP2 | poly(rC) binding protein 2 | 0.0585695 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0572094 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0562076 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0561293 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0546582 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0539491 |
| RNF213 | ring finger protein 213 | 0.0537862 |
| ADAR | adenosine deaminase, RNA-specific | 0.0525133 |
| RPL8 | ribosomal protein L8 | 0.0517811 |
| TPM3 | tropomyosin 3 | 0.0509568 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.050462 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0487736 |
| B2M | beta-2-microglobulin | 0.047975 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0476362 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0475447 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0474556 |
| RPS8 | ribosomal protein S8 | 0.0473818 |
| MYOF | myoferlin | 0.0472609 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0467832 |
| LDHA | lactate dehydrogenase A | 0.0464239 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0458286 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0456709 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0453595 |
| RPS3 | ribosomal protein S3 | 0.0451692 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0449391 |
| ZNF292 | zinc finger protein 292 | 0.0448691 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0447615 |
| TFG | TRK-fused gene | 0.0445612 |
| TXNIP | thioredoxin interacting protein | 0.0441164 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0439776 |
| RPS12 | ribosomal protein S12 | 0.0438416 |
| CD9 | CD9 molecule | 0.043522 |
| SQSTM1 | sequestosome 1 | 0.0424984 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0418403 |
| S100A6 | S100 calcium binding protein A6 | 0.0409986 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0409068 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0401453 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0399858 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0397359 |
| YBX1 | Y box binding protein 1 | 0.0381357 |
| RPS29 | ribosomal protein S29 | 0.0379706 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0378721 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0377654 |
| ARRDC3 | arrestin domain containing 3 | 0.0375536 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.037373 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0371206 |
| RPLP2 | ribosomal protein, large, P2 | 0.0367444 |
| CD109 | CD109 molecule | 0.0365086 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0363939 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0363195 |
| RPS6 | ribosomal protein S6 | 0.0361791 |
| HDGF | hepatoma-derived growth factor | 0.0359775 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.035861 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0358126 |
| YBX3 | Y box binding protein 3 | 0.0354754 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.035473 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0353527 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0353359 |
| VEGFA | vascular endothelial growth factor A | 0.0351758 |
| RPL12 | ribosomal protein L12 | 0.0351282 |
| PGK1 | phosphoglycerate kinase 1 | 0.0349972 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0349148 |
| ANXA2 | annexin A2 | 0.0348355 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0344172 |
| HELZ | helicase with zinc finger | 0.0342747 |
| FHIT | fragile histidine triad | 0.0341867 |
| RPL5 | ribosomal protein L5 | 0.0340024 |
| RPS13 | ribosomal protein S13 | 0.0339161 |
| YTHDC1 | YTH domain containing 1 | 0.0338835 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0336165 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0332485 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0328698 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0326118 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0326008 |
| RPS19 | ribosomal protein S19 | 0.0325653 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.032486 |
| GOLGA4 | golgin A4 | 0.0323561 |
| KRT18 | keratin 18, type I | 0.0323451 |
| CENPF | centromere protein F, 350/400kDa | 0.03218 |
| STEAP4 | STEAP family member 4 | 0.0321188 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.242464 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.201951 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.113914 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0902021 |
| LAMB3 | laminin, beta 3 | -0.0865468 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0820082 |
| ACTG1 | actin gamma 1 | -0.0781135 |
| FAM3C | family with sequence similarity 3, member C | -0.0774575 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0770522 |
| TOP1 | topoisomerase (DNA) I | -0.0708414 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0697508 |
| LMO7 | LIM domain 7 | -0.0663782 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.062562 |
| CDCP1 | CUB domain containing protein 1 | -0.0620664 |
| EFNA5 | ephrin-A5 | -0.0603927 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0470092 |
| DTNA | dystrobrevin, alpha | -0.0441745 |
| DUSP6 | dual specificity phosphatase 6 | -0.0439837 |
| CCND1 | cyclin D1 | -0.0438071 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.042742 |
| TMSB10 | thymosin beta 10 | -0.0427019 |
| SMAD3 | SMAD family member 3 | -0.0408039 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0396148 |
| SDC4 | syndecan 4 | -0.0396031 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0380278 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0377923 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0376857 |
| FAM107B | family with sequence similarity 107, member B | -0.036273 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0359021 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | -0.0346049 |
| ASPH | aspartate beta-hydroxylase | -0.034432 |
| EGR1 | early growth response 1 | -0.0343126 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0339004 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0325045 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0323222 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0323059 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0316724 |
| TMEM165 | transmembrane protein 165 | -0.0312969 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0311536 |
| LAMC2 | laminin, gamma 2 | -0.0310716 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0303981 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0303708 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0299722 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0299321 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0291462 |
| AGO2 | argonaute RISC catalytic component 2 | -0.028864 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0288406 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0273594 |
| FOSL1 | FOS-like antigen 1 | -0.0273195 |
| ETV5 | ets variant 5 | -0.0272832 |
| VGLL3 | vestigial-like family member 3 | -0.0272687 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0268692 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0260908 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0259383 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0250605 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0249265 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0245127 |
| UPP1 | uridine phosphorylase 1 | -0.0244771 |
| CAB39 | calcium binding protein 39 | -0.024362 |
| HMGA1 | high mobility group AT-hook 1 | -0.023996 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0235019 |
| ARF1 | ADP-ribosylation factor 1 | -0.0230847 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0228995 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0225518 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -0.0224601 |
| HPCAL1 | hippocalcin-like 1 | -0.0221985 |
| RCOR1 | REST corepressor 1 | -0.022016 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0219244 |
| NRP1 | neuropilin 1 | -0.0212514 |
| LOXL2 | lysyl oxidase-like 2 | -0.0209313 |
| ATP13A3 | ATPase type 13A3 | -0.0207801 |
| NF1 | neurofibromin 1 | -0.0207008 |
| KLF12 | Kruppel-like factor 12 | -0.0202737 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0197989 |
| ATP11B | ATPase, class VI, type 11B | -0.0196945 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0196812 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0192337 |
| ATXN1 | ataxin 1 | -0.0190843 |
| TGFA | transforming growth factor, alpha | -0.0189745 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.018839 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0187925 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.0184148 |
| TP53BP2 | tumor protein p53 binding protein 2 | -0.0182257 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0181599 |
| MYO1E | myosin IE | -0.0181414 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0181379 |
| RASA2 | RAS p21 protein activator 2 | -0.018125 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0179751 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0178439 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0178056 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0177573 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0176948 |
| EGFR | epidermal growth factor receptor | -0.0174171 |
| C3ORF52 | chromosome 3 open reading frame 52 | -0.0172912 |
| FOXO3 | forkhead box O3 | -0.0172731 |
| JMJD1C | jumonji domain containing 1C | -0.0171829 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0170049 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0169952 |
| PTK2B | protein tyrosine kinase 2 beta | -0.0169408 |
| TXNRD1 | thioredoxin reductase 1 | -0.0167731 |
