Trametinib (DMSO_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib (DMSO perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib (DMSO_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL5A2 collagen, type V, alpha 2 0.191352
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0928762
PM20D1 peptidase M20 domain containing 1 0.0813795
NEK7 NIMA-related kinase 7 0.0812191
PALLD palladin, cytoskeletal associated protein 0.0675076
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0661197
SMYD3 SET and MYND domain containing 3 0.0649296
COL8A1 collagen, type VIII, alpha 1 0.0594028
ADGRB3 adhesion G protein-coupled receptor B3 0.0583197
PDE4D phosphodiesterase 4D, cAMP-specific 0.0575876
AGTPBP1 ATP/GTP binding protein 1 0.0573379
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0496272
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0467376
WSB1 WD repeat and SOCS box containing 1 0.0465966
WARS1 tryptophanyl-tRNA synthetase 1 0.0445553
AKR1C1 aldo-keto reductase family 1, member C1 0.0444864
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0443167
STC2 stanniocalcin 2 0.0421179
KMT2C lysine (K)-specific methyltransferase 2C 0.0372022
PCDH15 protocadherin-related 15 0.0361721
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0354108
MAP7 microtubule-associated protein 7 0.0352918
CD109 CD109 molecule 0.0342592
OLFML2A olfactomedin-like 2A 0.0341138
PTEN phosphatase and tensin homolog 0.0339629
PBX1 pre-B-cell leukemia homeobox 1 0.0329246
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.0320918
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0320873
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0318461
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0318151
DGKD diacylglycerol kinase, delta 130kDa 0.031486
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0309036
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0303823
CHSY3 chondroitin sulfate synthase 3 0.0301639
IGF1R insulin-like growth factor 1 receptor 0.0297542
EPHA5 EPH receptor A5 0.0292643
LSAMP limbic system-associated membrane protein 0.0284054
DCLK2 doublecortin-like kinase 2 0.0283692
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0281945
ZFHX3 zinc finger homeobox 3 0.0281486
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.027817
MGST1 microsomal glutathione S-transferase 1 0.0277075
NALF1 NALCN channel auxiliary factor 1 0.0252655
FTL ferritin, light polypeptide 0.0248204
EEF2 eukaryotic translation elongation factor 2 0.0245358
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0243072
ENO1 enolase 1, (alpha) 0.0243039
ANXA2 annexin A2 0.0241186
AKR1C2 aldo-keto reductase family 1, member C2 0.0239748
TBXT T-box transcription factor T 0.0237613
XYLT1 xylosyltransferase I 0.0237134
TGFBI transforming growth factor, beta-induced, 68kDa 0.0231696
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.02246
ASPH aspartate beta-hydroxylase 0.02246
OGA O-GlcNAcase 0.0217887
PGK1 phosphoglycerate kinase 1 0.0217168
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0213816
CANX calnexin 0.0211968
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0207279
PTGR1 prostaglandin reductase 1 0.0206062
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0198183
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0195724
TENM3 teneurin transmembrane protein 3 0.0194626
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0194479
LGALS3 lectin, galactoside-binding, soluble, 3 0.0194177
DISP1 dispatched homolog 1 (Drosophila) 0.0184103
SSBP2 single-stranded DNA binding protein 2 0.0182406
PDGFC platelet derived growth factor C 0.0176089
ENAH enabled homolog (Drosophila) 0.0173929
PDGFA platelet-derived growth factor alpha polypeptide 0.0170945
RHOB ras homolog family member B 0.0170702
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0170282
RPL35A ribosomal protein L35a 0.0168693
TRIO trio Rho guanine nucleotide exchange factor 0.0168616
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.016809
UBE2H ubiquitin-conjugating enzyme E2H 0.0167845
IGFBP3 insulin-like growth factor binding protein 3 0.0160178
MFSD12 major facilitator superfamily domain containing 12 0.0160141
ADAM9 ADAM metallopeptidase domain 9 0.0159404
FBXO42 F-box protein 42 0.0159079
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0157892
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0157658
SKAP2 src kinase associated phosphoprotein 2 0.015708
UGDH UDP-glucose 6-dehydrogenase 0.0156907
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0153312
MINDY3 MINDY lysine 48 deubiquitinase 3 0.0152092
PCBP2 poly(rC) binding protein 2 0.0151118
P3H2 prolyl 3-hydroxylase 2 0.0150187
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.0149564
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0148234
TMX4 thioredoxin-related transmembrane protein 4 0.0146128
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0145724
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0144869
GANAB glucosidase, alpha; neutral AB 0.0143753
JADE1 jade family PHD finger 1 0.0143574
SETD7 SET domain containing (lysine methyltransferase) 7 0.0140098
PRR5L proline rich 5 like 0.0139163
CALR calreticulin 0.0138683
PRKD3 protein kinase D3 0.0138673
RIOK3 RIO kinase 3 0.0136698

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.288902
EFNA5 ephrin-A5 -0.256266
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.146443
GDA guanine deaminase -0.146304
PSD3 pleckstrin and Sec7 domain containing 3 -0.145649
CDH13 cadherin 13 -0.125607
NRCAM neuronal cell adhesion molecule -0.11028
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.110075
GRAMD1B GRAM domain containing 1B -0.106657
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.101849
DOCK4 dedicator of cytokinesis 4 -0.0973738
MCL1 myeloid cell leukemia 1 -0.0946404
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0938824
NPAS2 neuronal PAS domain protein 2 -0.0908113
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0794585
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0763486
MAML3 mastermind-like 3 (Drosophila) -0.0725851
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0722952
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0697662
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.062105
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.060963
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0605663
FNDC3A fibronectin type III domain containing 3A -0.0562505
RGS2 regulator of G-protein signaling 2 -0.0524
STC1 stanniocalcin 1 -0.0520199
PCBP3 poly(rC) binding protein 3 -0.0515255
DOCK5 dedicator of cytokinesis 5 -0.0502103
NAMPT nicotinamide phosphoribosyltransferase -0.0498248
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0491092
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0486933
SMOC1 SPARC related modular calcium binding 1 -0.0481734
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0460466
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.045981
PDLIM5 PDZ and LIM domain 5 -0.0456953
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0438732
COL4A5 collagen, type IV, alpha 5 -0.0430652
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0412747
FMNL2 formin-like 2 -0.0407543
RTN1 reticulon 1 -0.0407253
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0404491
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0399961
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0398207
SLC38A2 solute carrier family 38, member 2 -0.0397912
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0394187
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0394023
RAB3B RAB3B, member RAS oncogene family -0.0388079
GLIS3 GLIS family zinc finger 3 -0.0380861
TGFBR1 transforming growth factor, beta receptor 1 -0.0379469
TM4SF1 transmembrane 4 L six family member 1 -0.0370078
VCL vinculin -0.036962
MCTP1 multiple C2 domains, transmembrane 1 -0.0369536
FLNB filamin B, beta -0.0369454
PDE10A phosphodiesterase 10A -0.0367941
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0362413
COL4A6 collagen, type IV, alpha 6 -0.0357623
TFPI2 tissue factor pathway inhibitor 2 -0.0350775
NHSL1 NHS-like 1 -0.0324962
CD44 CD44 molecule (Indian blood group) -0.031456
BMERB1 bMERB domain containing 1 -0.0307298
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0303159
ADGRD1 adhesion G protein-coupled receptor D1 -0.0301894
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0300279
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0298116
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0295571
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0294637
EPHA4 EPH receptor A4 -0.0290347
THSD4 thrombospondin, type I, domain containing 4 -0.0290199
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0289459
ESYT2 extended synaptotagmin-like protein 2 -0.0283286
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0282136
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0280186
BCAR3 breast cancer anti-estrogen resistance 3 -0.0279133
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0278527
WWTR1 WW domain containing transcription regulator 1 -0.0277679
VIM vimentin -0.0271378
PTPRM protein tyrosine phosphatase, receptor type, M -0.0269809
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0267004
NT5C2 5'-nucleotidase, cytosolic II -0.0264119
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0262798
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0261012
PYGL phosphorylase, glycogen, liver -0.025965
DUSP4 dual specificity phosphatase 4 -0.0259543
CREB5 cAMP responsive element binding protein 5 -0.0258743
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -0.0257424
CHD1 chromodomain helicase DNA binding protein 1 -0.0256781
KYNU kynureninase -0.0250296
CCDC68 coiled-coil domain containing 68 -0.0247273
AKAP13 A kinase (PRKA) anchor protein 13 -0.0246471
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0246117
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0241783
ARHGAP5 Rho GTPase activating protein 5 -0.0235409
ESM1 endothelial cell-specific molecule 1 -0.0232832
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0231453
BMP6 bone morphogenetic protein 6 -0.0229856
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0229723
CENPF centromere protein F, 350/400kDa -0.0229194
PRRC2C proline-rich coiled-coil 2C -0.0226988
TOP1 topoisomerase (DNA) I -0.0226143
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0224743
ELL2 elongation factor, RNA polymerase II, 2 -0.0223047