Trametinib (DMSO_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib (DMSO perturbation in NCI-H596 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Trametinib (DMSO_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.263698
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.140752
PRKCA protein kinase C, alpha 0.130151
KIZ kizuna centrosomal protein 0.113852
ARHGAP32 Rho GTPase activating protein 32 0.110262
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.109639
TAS2R14 taste receptor, type 2, member 14 0.109615
EPS8 epidermal growth factor receptor pathway substrate 8 0.107516
FNBP4 formin binding protein 4 0.107032
TNS3 tensin 3 0.104732
PCDH9 protocadherin 9 0.0994072
RUNX1 runt-related transcription factor 1 0.0968722
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0877168
TRIM33 tripartite motif containing 33 0.0870152
PICALM phosphatidylinositol binding clathrin assembly protein 0.0853312
KMT2E lysine (K)-specific methyltransferase 2E 0.0835599
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0833093
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0831752
MBNL2 muscleblind-like splicing regulator 2 0.0823914
HOOK2 hook microtubule-tethering protein 2 0.0796582
ANKHD1 ankyrin repeat and KH domain containing 1 0.0791183
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0784598
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0765368
SYT1 synaptotagmin I 0.074951
ANKRD11 ankyrin repeat domain 11 0.0749319
CERS6 ceramide synthase 6 0.0741283
PCBP2 poly(rC) binding protein 2 0.0738242
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0732424
RAB10 RAB10, member RAS oncogene family 0.0727416
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0708623
GOLGA4 golgin A4 0.0683144
TTC3 tetratricopeptide repeat domain 3 0.0681127
CDC73 cell division cycle 73 0.0661965
SP100 SP100 nuclear antigen 0.0635466
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0635086
ZNF644 zinc finger protein 644 0.0612821
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0612357
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0606577
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0594747
ZBTB20 zinc finger and BTB domain containing 20 0.0594666
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0572942
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0566139
VCL vinculin 0.0566133
GOLGB1 golgin B1 0.0560288
TRIO trio Rho guanine nucleotide exchange factor 0.0547841
PDE4B phosphodiesterase 4B, cAMP-specific 0.0547566
RBM39 RNA binding motif protein 39 0.0537741
DENND5B DENN/MADD domain containing 5B 0.0533014
GLG1 golgi glycoprotein 1 0.0521888
RAB1A RAB1A, member RAS oncogene family 0.0519256
ADNP activity-dependent neuroprotector homeobox 0.0457989
CUX1 cut-like homeobox 1 0.0455974
FTL ferritin, light polypeptide 0.0453431
NKD1 naked cuticle homolog 1 (Drosophila) 0.0441723
FNIP1 folliculin interacting protein 1 0.0419086
SQSTM1 sequestosome 1 0.0416776
DST dystonin 0.0370162
TPT1 tumor protein, translationally-controlled 1 0.0359329
NAMPT nicotinamide phosphoribosyltransferase 0.0358976
ESYT2 extended synaptotagmin-like protein 2 0.0357449
KMT2C lysine (K)-specific methyltransferase 2C 0.0348367
SPIDR scaffolding protein involved in DNA repair 0.034723
OXR1 oxidation resistance 1 0.0335912
SMYD3 SET and MYND domain containing 3 0.033264
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0331422
B2M beta-2-microglobulin 0.0326325
AHNAK AHNAK nucleoprotein 0.0321696
DLG1 discs, large homolog 1 (Drosophila) 0.0318294
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0311355
NAV2 neuron navigator 2 0.0280841
GARS1 glycyl-tRNA synthetase 1 0.0267813
RPL35A ribosomal protein L35a 0.0252512
CLTC clathrin, heavy chain (Hc) 0.0250659
JMJD1C jumonji domain containing 1C 0.024822
AKAP13 A kinase (PRKA) anchor protein 13 0.0244482
SETD5 SET domain containing 5 0.0237586
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0219183
SEC31A SEC31 homolog A (S. cerevisiae) 0.0212314
DSCAM Down syndrome cell adhesion molecule 0.0212002
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0199933
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0178068
MYO1E myosin IE 0.0167591
WDFY3 WD repeat and FYVE domain containing 3 0.0153299
PGK1 phosphoglycerate kinase 1 0.0151944
FNDC3A fibronectin type III domain containing 3A 0.0144087
MYOF myoferlin 0.0138698
GPC6 glypican 6 0.0129672
HELZ helicase with zinc finger 0.0119399
PTMA prothymosin, alpha 0.011014
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0108235
CANX calnexin 0.01076
PRRC2C proline-rich coiled-coil 2C 0.00989048
ANKRD12 ankyrin repeat domain 12 0.00930144
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.00791995
KDM6A lysine (K)-specific demethylase 6A 0.00768635
RPS8 ribosomal protein S8 0.00706607
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.00630396
PDLIM5 PDZ and LIM domain 5 0.003833
ARID4B AT rich interactive domain 4B (RBP1-like) 0.00218643
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.00139652

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.176663
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.162947
EGFR epidermal growth factor receptor -0.127985
FNDC3B fibronectin type III domain containing 3B -0.123425
LAMA4 laminin, alpha 4 -0.117457
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.107629
SRRM2 serine/arginine repetitive matrix 2 -0.103884
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.103644
MAML3 mastermind-like 3 (Drosophila) -0.102624
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0931042
PDE4D phosphodiesterase 4D, cAMP-specific -0.0911083
PSD3 pleckstrin and Sec7 domain containing 3 -0.0885686
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0883189
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0839088
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0806234
AKAP12 A kinase (PRKA) anchor protein 12 -0.0790464
TXNRD1 thioredoxin reductase 1 -0.0767782
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0752854
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0751268
VIM vimentin -0.0744546
GPHN gephyrin -0.0740633
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0738354
NDRG1 N-myc downstream regulated 1 -0.0734699
INHBA inhibin, beta A -0.0712692
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0704773
RAB7A RAB7A, member RAS oncogene family -0.0700181
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0680005
TMSB10 thymosin beta 10 -0.0672706
PDE8A phosphodiesterase 8A -0.0658637
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0644921
ELL2 elongation factor, RNA polymerase II, 2 -0.0641587
KTN1 kinectin 1 (kinesin receptor) -0.0638394
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0637155
DOCK4 dedicator of cytokinesis 4 -0.0634161
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.063052
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0620399
RPL15 ribosomal protein L15 -0.0617805
MRPS6 mitochondrial ribosomal protein S6 -0.0613175
NALF1 NALCN channel auxiliary factor 1 -0.0609954
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0601998
EXT1 exostosin glycosyltransferase 1 -0.0591976
ASPH aspartate beta-hydroxylase -0.0557967
NAP1L1 nucleosome assembly protein 1-like 1 -0.0541219
JARID2 jumonji, AT rich interactive domain 2 -0.0535995
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0522446
BACE2 beta-site APP-cleaving enzyme 2 -0.0508822
COL6A3 collagen, type VI, alpha 3 -0.0495656
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0492844
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0486612
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0476361
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0461528
ENO1 enolase 1, (alpha) -0.045307
PIBF1 progesterone immunomodulatory binding factor 1 -0.0452001
CDH13 cadherin 13 -0.0449974
FAM13A family with sequence similarity 13, member A -0.0449669
EFNA5 ephrin-A5 -0.0436735
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0429457
DOCK5 dedicator of cytokinesis 5 -0.0428356
EIF1 eukaryotic translation initiation factor 1 -0.0421535
TBC1D22A TBC1 domain family, member 22A -0.0421435
LMAN1 lectin, mannose-binding, 1 -0.0420728
SH3KBP1 SH3-domain kinase binding protein 1 -0.0420525
SLTM SAFB-like, transcription modulator -0.0407092
MYO10 myosin X -0.0405061
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0402554
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0386394
SMC5 structural maintenance of chromosomes 5 -0.037212
ZNF609 zinc finger protein 609 -0.0342988
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0334506
COL6A1 collagen, type VI, alpha 1 -0.0322263
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0314243
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0313879
ANXA2 annexin A2 -0.0303404
SPAG9 sperm associated antigen 9 -0.0301797
CEP170 centrosomal protein 170kDa -0.0295191
RB1CC1 RB1-inducible coiled-coil 1 -0.0295114
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0280731
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0266492
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0257941
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0254905
PTK2 protein tyrosine kinase 2 -0.0250402
ZNF292 zinc finger protein 292 -0.0247778
CSDE1 cold shock domain containing E1, RNA-binding -0.0246943
SBF2 SET binding factor 2 -0.0237027
OSMR oncostatin M receptor -0.0230622
NIPBL Nipped-B homolog (Drosophila) -0.0228524
CD44 CD44 molecule (Indian blood group) -0.0220844
AFF4 AF4/FMR2 family, member 4 -0.0214371
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0203838
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0200096
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0196065
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0190376
CALU calumenin -0.0181043
FN1 fibronectin 1 -0.0162208
SAMD4A sterile alpha motif domain containing 4A -0.0151596
TMEM165 transmembrane protein 165 -0.0136027
PRELID2 PRELI domain containing 2 -0.0119671
OGA O-GlcNAcase -0.0118318
VMP1 vacuole membrane protein 1 -0.0118208
MED13L mediator complex subunit 13-like -0.0108473