| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.159908 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.140059 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.1079 |
| DST | dystonin | 0.10501 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.104041 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0968286 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0868304 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0860974 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0780191 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0751785 |
| ANXA1 | annexin A1 | 0.0747583 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0724659 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0723829 |
| PGK1 | phosphoglycerate kinase 1 | 0.0696028 |
| ZNF292 | zinc finger protein 292 | 0.0682602 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0652742 |
| PHIP | pleckstrin homology domain interacting protein | 0.0647985 |
| RPS12 | ribosomal protein S12 | 0.0626423 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.062152 |
| GPC3 | glypican 3 | 0.0618408 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0593126 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0589645 |
| CALR | calreticulin | 0.0584307 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.058064 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0572767 |
| RASAL2 | RAS protein activator like 2 | 0.0569396 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0563709 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0559908 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0552499 |
| NCKAP1 | NCK-associated protein 1 | 0.0538796 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0536366 |
| STAG2 | stromal antigen 2 | 0.0535879 |
| MKI67 | marker of proliferation Ki-67 | 0.0530638 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0530508 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0527708 |
| UTRN | utrophin | 0.0523192 |
| PCBP2 | poly(rC) binding protein 2 | 0.0519573 |
| NTM | neurotrimin | 0.0517983 |
| CFL2 | cofilin 2 (muscle) | 0.0517788 |
| ANKRD33B | ankyrin repeat domain 33B | 0.051371 |
| ENAH | enabled homolog (Drosophila) | 0.0510631 |
| THBS1 | thrombospondin 1 | 0.0491679 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.048589 |
| RREB1 | ras responsive element binding protein 1 | 0.0482449 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0476051 |
| RPL5 | ribosomal protein L5 | 0.0474057 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.047369 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0473085 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0469216 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0467258 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0465874 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0464546 |
| RBM33 | RNA binding motif protein 33 | 0.0464451 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0464232 |
| COL3A1 | collagen, type III, alpha 1 | 0.0447569 |
| KIF1B | kinesin family member 1B | 0.0443 |
| TPM3 | tropomyosin 3 | 0.0440818 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0440443 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0437674 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0435063 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0434134 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0429945 |
| ITGAV | integrin, alpha V | 0.0426513 |
| CANX | calnexin | 0.0426192 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0425205 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0425148 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0421166 |
| PCDH9 | protocadherin 9 | 0.0415912 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0403491 |
| ANLN | anillin, actin binding protein | 0.0396828 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0396768 |
| GPC4 | glypican 4 | 0.039026 |
| FAT1 | FAT atypical cadherin 1 | 0.0389765 |
| ENO1 | enolase 1, (alpha) | 0.0385203 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0383995 |
| ECT2 | epithelial cell transforming 2 | 0.0383238 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0378775 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0368069 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.036631 |
| NCOA1 | nuclear receptor coactivator 1 | 0.0365703 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0364293 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0361401 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0360492 |
| RBM20 | RNA binding motif protein 20 | 0.0354331 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0353102 |
| LRRC4C | leucine rich repeat containing 4C | 0.0352555 |
| PDS5B | PDS5 cohesin associated factor B | 0.0351339 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0350798 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0350795 |
| CORO1C | coronin, actin binding protein, 1C | 0.0349256 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0348568 |
| PDGFC | platelet derived growth factor C | 0.0348484 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0347336 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0347003 |
| GAB2 | GRB2-associated binding protein 2 | 0.034616 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0345854 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0344642 |
| ATXN2 | ataxin 2 | 0.0344144 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0340977 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0340252 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0573231 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0454472 |
| TMSB10 | thymosin beta 10 | -0.0438949 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0428598 |
| RPS16 | ribosomal protein S16 | -0.0404196 |
| MEIS2 | Meis homeobox 2 | -0.0397169 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.038541 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0351082 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.034739 |
| TMSB4X | thymosin beta 4, X-linked | -0.0340893 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0326036 |
| RPLP1 | ribosomal protein, large, P1 | -0.0321701 |
| NF1 | neurofibromin 1 | -0.0320747 |
| CDH19 | cadherin 19, type 2 | -0.0312764 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0289123 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0280143 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0275753 |
| HMGA2 | high mobility group AT-hook 2 | -0.027565 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0266217 |
| NFIA | nuclear factor I/A | -0.0261709 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0249524 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0244854 |
| SYT1 | synaptotagmin I | -0.0240336 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0231737 |
| DUSP6 | dual specificity phosphatase 6 | -0.0230028 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0221416 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0203586 |
| TET2 | tet methylcytosine dioxygenase 2 | -0.020243 |
| DACH1 | dachshund family transcription factor 1 | -0.0202097 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0198887 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.0197438 |
| SHROOM3 | shroom family member 3 | -0.0195785 |
| KIAA1328 | KIAA1328 | -0.0195521 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.0195365 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0194922 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0191631 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | -0.019098 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | -0.0190815 |
| RPL38 | ribosomal protein L38 | -0.0188469 |
| BBX | bobby sox homolog (Drosophila) | -0.0187585 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0187131 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | -0.0186303 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0183085 |
| HMGB1 | high mobility group box 1 | -0.0182904 |
| ARF1 | ADP-ribosylation factor 1 | -0.0180659 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0180387 |
| EPHA5 | EPH receptor A5 | -0.0179168 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0179054 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0178827 |
| RPL34 | ribosomal protein L34 | -0.0178191 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.017769 |
| GTDC1 | glycosyltransferase-like domain containing 1 | -0.0174017 |
| RARS2 | arginyl-tRNA synthetase 2, mitochondrial | -0.0173915 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0171891 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0171553 |
| FBL | fibrillarin | -0.0169261 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0169221 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.016882 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0167143 |
| RPL4 | ribosomal protein L4 | -0.0166845 |
| HMGA1 | high mobility group AT-hook 1 | -0.0164544 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0164288 |
| IRAK1BP1 | interleukin-1 receptor-associated kinase 1 binding protein 1 | -0.0162947 |
| HBP1 | HMG-box transcription factor 1 | -0.0162632 |
| SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | -0.0162039 |
| UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 | -0.0160901 |
| COG5 | component of oligomeric golgi complex 5 | -0.0160789 |
| ETV1 | ets variant 1 | -0.0160491 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0159808 |
| PCNX4 | pecanex 4 | -0.0158598 |
| BANF1 | barrier to autointegration factor 1 | -0.0158468 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0157114 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0157109 |
| SPAG9 | sperm associated antigen 9 | -0.0156907 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0156454 |
| RAB3GAP2 | RAB3 GTPase activating protein subunit 2 (non-catalytic) | -0.0155951 |
| NAT10 | N-acetyltransferase 10 (GCN5-related) | -0.0155509 |
| FBXO17 | F-box protein 17 | -0.0154692 |
| GOSR2 | golgi SNAP receptor complex member 2 | -0.0154288 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0154175 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | -0.0154125 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0153931 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0153835 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.0152508 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0152001 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0151346 |
| RPL28 | ribosomal protein L28 | -0.0151332 |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | -0.0151192 |
| RB1 | retinoblastoma 1 | -0.0150847 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0150674 |
| ACTN4 | actinin, alpha 4 | -0.0150274 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0149503 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.0148839 |
| GOLGB1 | golgin B1 | -0.01485 |
| ETNK1 | ethanolamine kinase 1 | -0.014757 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | -0.0147099 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0146969 |
| ZNF644 | zinc finger protein 644 | -0.0146344 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.0146222 |
| FRMD5 | FERM domain containing 5 | -0.0145349 |
