| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.124588 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.109325 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0896448 |
| TNS3 | tensin 3 | 0.0653862 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0582211 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.052359 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0518072 |
| SFTPA2 | surfactant protein A2 | 0.0513817 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0509687 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0505153 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0497742 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.049121 |
| SQSTM1 | sequestosome 1 | 0.0471402 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.0452603 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0448805 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0441532 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0432562 |
| SPAG9 | sperm associated antigen 9 | 0.0405838 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.040568 |
| FBL | fibrillarin | 0.0404973 |
| FTL | ferritin, light polypeptide | 0.0396244 |
| PCBP2 | poly(rC) binding protein 2 | 0.0394087 |
| ADM | adrenomedullin | 0.0376934 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0370842 |
| RNF213 | ring finger protein 213 | 0.0370015 |
| MED13L | mediator complex subunit 13-like | 0.0369857 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0358837 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.035761 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0354377 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0341225 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0331127 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0319468 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0317542 |
| FLNB | filamin B, beta | 0.0313078 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0312815 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0312425 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0311787 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0309994 |
| LDHA | lactate dehydrogenase A | 0.0308725 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0308378 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0303582 |
| YBX1 | Y box binding protein 1 | 0.0300508 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0299785 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0298549 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0297855 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.029477 |
| FMNL2 | formin-like 2 | 0.0293321 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0292695 |
| CALR | calreticulin | 0.0290345 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0288021 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0280701 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0279532 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0275919 |
| ANXA2 | annexin A2 | 0.0270485 |
| BRD2 | bromodomain containing 2 | 0.0269847 |
| B2M | beta-2-microglobulin | 0.0269167 |
| XPO1 | exportin 1 | 0.0265123 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.026113 |
| ATF6 | activating transcription factor 6 | 0.0260118 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0259631 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0259354 |
| LMNA | lamin A/C | 0.0257175 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0255625 |
| PLEC | plectin | 0.0254406 |
| TMEM123 | transmembrane protein 123 | 0.0253527 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0252371 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0250414 |
| ZFP36 | ZFP36 ring finger protein | 0.0249184 |
| DST | dystonin | 0.0247555 |
| SMAD3 | SMAD family member 3 | 0.0244662 |
| GOLGA4 | golgin A4 | 0.0243721 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0241392 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0241357 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0240728 |
| COL5A2 | collagen, type V, alpha 2 | 0.0237264 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0236845 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.023552 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0235202 |
| USP12 | ubiquitin specific peptidase 12 | 0.0232989 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0231738 |
| RLF | rearranged L-myc fusion | 0.0231679 |
| JAK1 | Janus kinase 1 | 0.0226203 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.022245 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0220166 |
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 0.0219806 |
| TPD52 | tumor protein D52 | 0.0218779 |
| JUN | jun proto-oncogene | 0.0218448 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0216112 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0214656 |
| NCKAP1 | NCK-associated protein 1 | 0.0213145 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0210459 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0210391 |
| OGA | O-GlcNAcase | 0.0204122 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0202188 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0201852 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0201545 |
| SUCO | SUN domain containing ossification factor | 0.0200924 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0200359 |
| SIK3 | SIK family kinase 3 | 0.0200074 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.019947 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.322355 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.142075 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.112184 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.108412 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.10539 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.103745 |
| SLC35F3 | solute carrier family 35, member F3 | -0.102866 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0958838 |
| CD44 | CD44 molecule (Indian blood group) | -0.0906528 |
| VIM | vimentin | -0.0829989 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0818625 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0813099 |
| VCL | vinculin | -0.0792911 |
| RPS16 | ribosomal protein S16 | -0.0677561 |
| ASPH | aspartate beta-hydroxylase | -0.0658961 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0647345 |
| HMGA2 | high mobility group AT-hook 2 | -0.063029 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0612295 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.059256 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | -0.0578247 |
| RTN4 | reticulon 4 | -0.0571052 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0547163 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0521352 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0520901 |
| MCL1 | myeloid cell leukemia 1 | -0.0515395 |
| CDCP1 | CUB domain containing protein 1 | -0.0515114 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0513507 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0469296 |
| ITGB5 | integrin, beta 5 | -0.0460251 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0456707 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.04466 |
| CARD18 | caspase recruitment domain family, member 18 | -0.0445229 |
| ACTN4 | actinin, alpha 4 | -0.0445203 |
| FHL2 | four and a half LIM domains 2 | -0.0438234 |
| ATG7 | autophagy related 7 | -0.043505 |
| EFNA5 | ephrin-A5 | -0.0430052 |
| MT2A | metallothionein 2A | -0.0429403 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0426652 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0424388 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0412852 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0412009 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0407612 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0404347 |
| ZNF780B | zinc finger protein 780B | -0.0390209 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0384998 |
| FOSL1 | FOS-like antigen 1 | -0.0379014 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0373079 |
| EGR1 | early growth response 1 | -0.036189 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0357518 |
| DNMBP | dynamin binding protein | -0.0341387 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0333408 |
| RAD51B | RAD51 paralog B | -0.0319451 |
| ANGPTL4 | angiopoietin-like 4 | -0.0318373 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0308197 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0299935 |
| PDE10A | phosphodiesterase 10A | -0.0298934 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0294686 |
| SMYD3 | SET and MYND domain containing 3 | -0.0293187 |
| BMERB1 | bMERB domain containing 1 | -0.0292341 |
| FAM3C | family with sequence similarity 3, member C | -0.0290858 |
| TMSB10 | thymosin beta 10 | -0.0288844 |
| NHSL1 | NHS-like 1 | -0.0286306 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0284967 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0284834 |
| CENPF | centromere protein F, 350/400kDa | -0.0279103 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0274184 |
| VMP1 | vacuole membrane protein 1 | -0.0272175 |
| NAV2 | neuron navigator 2 | -0.0269026 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0266791 |
| RNF220 | ring finger protein 220 | -0.0265382 |
| NF1 | neurofibromin 1 | -0.0262891 |
| MKI67 | marker of proliferation Ki-67 | -0.0259255 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0250023 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0240483 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.023857 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0237471 |
| BCL2L1 | BCL2-like 1 | -0.0237332 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0235784 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0233983 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0233586 |
| SNX14 | sorting nexin 14 | -0.022965 |
| ST3GAL3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | -0.022897 |
| PRSS23 | protease, serine, 23 | -0.0225957 |
| MOSMO | modulator of smoothened | -0.022516 |
| AFAP1 | actin filament associated protein 1 | -0.0224091 |
| CCND1 | cyclin D1 | -0.0223696 |
| NABP1 | nucleic acid binding protein 1 | -0.0223363 |
| PYGB | phosphorylase, glycogen; brain | -0.0222236 |
| MAP1B | microtubule-associated protein 1B | -0.0221607 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.0221515 |
| MYO10 | myosin X | -0.0218444 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0215903 |
| DIAPH2 | diaphanous-related formin 2 | -0.0209469 |
| DHX32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | -0.0204919 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0204763 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0204695 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0204501 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.0203765 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0203332 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.019951 |
