| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.111847 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.108271 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.105314 |
| KRT17 | keratin 17, type I | 0.0989434 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0864758 |
| RNF213 | ring finger protein 213 | 0.0783498 |
| ANLN | anillin, actin binding protein | 0.0676792 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0663436 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0655616 |
| ARRDC3 | arrestin domain containing 3 | 0.0570686 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0565986 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0550334 |
| DSPP | dentin sialophosphoprotein | 0.0525732 |
| EFNA5 | ephrin-A5 | 0.0516441 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0515 |
| XPO1 | exportin 1 | 0.0512734 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.050885 |
| MX1 | MX dynamin-like GTPase 1 | 0.0501258 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0495658 |
| OGA | O-GlcNAcase | 0.0493713 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0489416 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0482828 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0482495 |
| RUNX1 | runt-related transcription factor 1 | 0.0480406 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0468027 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0455168 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0453545 |
| B2M | beta-2-microglobulin | 0.0452966 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0441436 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0437533 |
| STK24 | serine/threonine kinase 24 | 0.043615 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.043309 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0428796 |
| ETV6 | ets variant 6 | 0.0425764 |
| RBM39 | RNA binding motif protein 39 | 0.0424345 |
| ZNF292 | zinc finger protein 292 | 0.0424343 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0424277 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.0420674 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0420612 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0417178 |
| HMGB2 | high mobility group box 2 | 0.0403496 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0399384 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0396216 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0395669 |
| GOLGA4 | golgin A4 | 0.0395066 |
| DST | dystonin | 0.0393484 |
| BBX | bobby sox homolog (Drosophila) | 0.0392651 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.039146 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0391294 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0387662 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0387523 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0382836 |
| KRT18 | keratin 18, type I | 0.0382598 |
| CFB | complement factor B | 0.0378739 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0376698 |
| CD47 | CD47 molecule | 0.0375873 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0372907 |
| CD2AP | CD2-associated protein | 0.0372019 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0371392 |
| NCKAP1 | NCK-associated protein 1 | 0.0369855 |
| PCBP2 | poly(rC) binding protein 2 | 0.0367675 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.036629 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0363602 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0361891 |
| ZNF148 | zinc finger protein 148 | 0.0354588 |
| WWC1 | WW and C2 domain containing 1 | 0.0352677 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0351741 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0349516 |
| TFG | TRK-fused gene | 0.0349329 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0345253 |
| ADAR | adenosine deaminase, RNA-specific | 0.0343935 |
| ECT2 | epithelial cell transforming 2 | 0.0343451 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.033799 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0336395 |
| ANXA1 | annexin A1 | 0.0336116 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0335512 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.0335098 |
| MED13L | mediator complex subunit 13-like | 0.0334888 |
| PTK2 | protein tyrosine kinase 2 | 0.0334196 |
| MUC4 | mucin 4, cell surface associated | 0.0327622 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0324473 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0323007 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.03217 |
| IFI44 | interferon-induced protein 44 | 0.0320169 |
| SHROOM3 | shroom family member 3 | 0.0318207 |
| DENND4C | DENN/MADD domain containing 4C | 0.0318095 |
| SPAG9 | sperm associated antigen 9 | 0.031709 |
| THBS1 | thrombospondin 1 | 0.031638 |
| NEK7 | NIMA-related kinase 7 | 0.0314356 |
| CANX | calnexin | 0.0313917 |
| TMEM123 | transmembrane protein 123 | 0.0313291 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0313127 |
| PHF21A | PHD finger protein 21A | 0.0312827 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0310384 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0309453 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0308577 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0308044 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0307727 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0307655 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0306254 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.178087 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.172677 |
| LMO7 | LIM domain 7 | -0.15762 |
| HMGA1 | high mobility group AT-hook 1 | -0.106933 |
| LAMA4 | laminin, alpha 4 | -0.0927318 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.089761 |
| TMSB10 | thymosin beta 10 | -0.0875018 |
| CD44 | CD44 molecule (Indian blood group) | -0.0791713 |
| EMP1 | epithelial membrane protein 1 | -0.0774179 |
| EGR1 | early growth response 1 | -0.0770717 |
| LAMB3 | laminin, beta 3 | -0.0730923 |
| INTS6 | integrator complex subunit 6 | -0.0723553 |
| FN1 | fibronectin 1 | -0.0689945 |
| LAMC2 | laminin, gamma 2 | -0.0620489 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0605603 |
| NDRG1 | N-myc downstream regulated 1 | -0.0578239 |
| ACTG1 | actin gamma 1 | -0.0577427 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0511563 |
| CDCP1 | CUB domain containing protein 1 | -0.0507366 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0484737 |
| SVIL | supervillin | -0.0478242 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0466613 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0441062 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0430251 |
| CCND1 | cyclin D1 | -0.0408849 |
| FOSL1 | FOS-like antigen 1 | -0.0403294 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0396215 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0395507 |
| HDAC9 | histone deacetylase 9 | -0.0395073 |
| EGFR | epidermal growth factor receptor | -0.0392519 |
| FTL | ferritin, light polypeptide | -0.0365313 |
| SYT14 | synaptotagmin XIV | -0.0354414 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0353809 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0352379 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | -0.0346059 |
| HMGA2 | high mobility group AT-hook 2 | -0.03459 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0341069 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0339438 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0339123 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0333591 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0332662 |
| ITGA6 | integrin, alpha 6 | -0.0323812 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0323704 |
| TPM4 | tropomyosin 4 | -0.0320509 |
| AREG | amphiregulin | -0.0318978 |
| MT2A | metallothionein 2A | -0.0305654 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0297024 |
| RPS6 | ribosomal protein S6 | -0.0295186 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0292072 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0290344 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0287704 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0284828 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0283344 |
| S100A6 | S100 calcium binding protein A6 | -0.0279355 |
| PLSCR1 | phospholipid scramblase 1 | -0.0274502 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0270363 |
| CLDN4 | claudin 4 | -0.0268967 |
| MYEOV | myeloma overexpressed | -0.0262793 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0261259 |
| G0S2 | G0/G1 switch 2 | -0.0257055 |
| EFNB2 | ephrin-B2 | -0.0255904 |
| BCL2L1 | BCL2-like 1 | -0.0254396 |
| TGM2 | transglutaminase 2 | -0.0249141 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0247687 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0246266 |
| MELTF | melanotransferrin | -0.0246054 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0245666 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0244286 |
| LIPH | lipase, member H | -0.0243802 |
| GNAS | GNAS complex locus | -0.024365 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0239738 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0239314 |
| FLNB | filamin B, beta | -0.0237405 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0237145 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.023497 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0233091 |
| TGFA | transforming growth factor, alpha | -0.0232576 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0231297 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0229213 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0229133 |
| THRB | thyroid hormone receptor, beta | -0.0228053 |
| POTEF | POTE ankyrin domain family, member F | -0.022326 |
| ANXA2 | annexin A2 | -0.0221978 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0220992 |
| OSMR | oncostatin M receptor | -0.0220716 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0219668 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0218729 |
| RPS5 | ribosomal protein S5 | -0.0218688 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0217659 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0216791 |
| RPL34 | ribosomal protein L34 | -0.021564 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0215375 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0211506 |
| GATAD2A | GATA zinc finger domain containing 2A | -0.0209633 |
| RASAL2 | RAS protein activator like 2 | -0.0208987 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0208077 |
| CARD11 | caspase recruitment domain family, member 11 | -0.0208072 |
| RPS20 | ribosomal protein S20 | -0.0207775 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0205278 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0201869 |
