| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0727514 |
| CALD1 | caldesmon 1 | 0.0700123 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0674241 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0665407 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0599862 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0597963 |
| ANK2 | ankyrin 2, neuronal | 0.0542108 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0479615 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.046659 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0369666 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.036438 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0358497 |
| MX1 | MX dynamin-like GTPase 1 | 0.0355221 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0350046 |
| EXOC4 | exocyst complex component 4 | 0.0343735 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0340614 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0335498 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0333855 |
| FLNA | filamin A, alpha | 0.0330097 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0315955 |
| MEF2A | myocyte enhancer factor 2A | 0.0307862 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.030747 |
| PTK2 | protein tyrosine kinase 2 | 0.0296444 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0294852 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0294562 |
| FHIT | fragile histidine triad | 0.0292642 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.028102 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0280988 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0275672 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0273904 |
| ADAR | adenosine deaminase, RNA-specific | 0.0266357 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0250831 |
| DST | dystonin | 0.0247513 |
| AHNAK | AHNAK nucleoprotein | 0.0244448 |
| MX2 | MX dynamin-like GTPase 2 | 0.02444 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0244148 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.024007 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0239317 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0237057 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | 0.0236493 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0233395 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0231039 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0230699 |
| UTRN | utrophin | 0.0229401 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.022845 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0227758 |
| CUX1 | cut-like homeobox 1 | 0.0227089 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0224552 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0220813 |
| HLA-C | major histocompatibility complex, class I, C | 0.021847 |
| RAD51B | RAD51 paralog B | 0.0216819 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0215394 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0211631 |
| AOPEP | aminopeptidase O (putative) | 0.0206776 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0204976 |
| NFIB | nuclear factor I/B | 0.0203013 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0202845 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0202554 |
| MYOF | myoferlin | 0.0196024 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0195904 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0193037 |
| NCOA2 | nuclear receptor coactivator 2 | 0.019275 |
| RBM39 | RNA binding motif protein 39 | 0.0192692 |
| PTEN | phosphatase and tensin homolog | 0.01923 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0190904 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0189976 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0189673 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0187624 |
| WDR43 | WD repeat domain 43 | 0.0184829 |
| CRY1 | cryptochrome circadian clock 1 | 0.0184427 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.01844 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0184207 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0182315 |
| SBF2 | SET binding factor 2 | 0.0182267 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0181933 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0180821 |
| CPQ | carboxypeptidase Q | 0.0180161 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0180135 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0179644 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0179285 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0176561 |
| RBM6 | RNA binding motif protein 6 | 0.0175189 |
| CCDC91 | coiled-coil domain containing 91 | 0.0174686 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0174502 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0172349 |
| CMIP | c-Maf inducing protein | 0.0170796 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0170505 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0170269 |
| RNF213 | ring finger protein 213 | 0.0168654 |
| PCBP2 | poly(rC) binding protein 2 | 0.0167207 |
| AATF | apoptosis antagonizing transcription factor | 0.0166718 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0166591 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0166553 |
| RIGI | RNA sensor RIG-I | 0.0166531 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0166439 |
| ANO6 | anoctamin 6 | 0.0166415 |
| MRTFA | myocardin related transcription factor A | 0.0166144 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0165539 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.016494 |
| FAM168A | family with sequence similarity 168, member A | 0.0164651 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAV3 | neuron navigator 3 | -0.152828 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.143309 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.130409 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.103484 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.103156 |
| STC1 | stanniocalcin 1 | -0.090967 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0909583 |
| LAMB3 | laminin, beta 3 | -0.0856928 |
| MT2A | metallothionein 2A | -0.0848332 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0821023 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0774876 |
| FRMD4A | FERM domain containing 4A | -0.0756808 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0732893 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0673873 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.067174 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0656 |
| HMGA2 | high mobility group AT-hook 2 | -0.0644508 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0637087 |
| RPS6 | ribosomal protein S6 | -0.0636456 |
| HMGA1 | high mobility group AT-hook 1 | -0.0565446 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0529519 |
| ACTG1 | actin gamma 1 | -0.0526484 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0505663 |
| FLNB | filamin B, beta | -0.0475578 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0470576 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0442166 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0440028 |
| RASA2 | RAS p21 protein activator 2 | -0.0435149 |
| FOSL1 | FOS-like antigen 1 | -0.0427917 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0406229 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0400733 |
| MTDH | metadherin | -0.0398037 |
| UPP1 | uridine phosphorylase 1 | -0.0381636 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0378079 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0354383 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0352847 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0347374 |
| DGKI | diacylglycerol kinase, iota | -0.0347143 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0346973 |
| RPS8 | ribosomal protein S8 | -0.0345134 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0339803 |
| CALU | calumenin | -0.0335907 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -0.0335646 |
| RPL23 | ribosomal protein L23 | -0.0333717 |
| RPS19 | ribosomal protein S19 | -0.0333243 |
| EGR1 | early growth response 1 | -0.0331907 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0329477 |
| NUP58 | nucleoporin 58 | -0.0325172 |
| ENO1 | enolase 1, (alpha) | -0.0324064 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0316372 |
| RPL12 | ribosomal protein L12 | -0.0311999 |
| RUNX1 | runt-related transcription factor 1 | -0.0310155 |
| SETX | senataxin | -0.0302833 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0299832 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.029791 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0297206 |
| FKBP15 | FK506 binding protein 15, 133kDa | -0.0295578 |
| TOP1 | topoisomerase (DNA) I | -0.0294485 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0289732 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -0.0286752 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0286461 |
| RPLP1 | ribosomal protein, large, P1 | -0.028614 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0284477 |
| RPL13A | ribosomal protein L13a | -0.0281647 |
| RACK1 | receptor for activated C kinase 1 | -0.0280248 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.027636 |
| RPS3 | ribosomal protein S3 | -0.0274318 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0273718 |
| RPL7 | ribosomal protein L7 | -0.0272845 |
| DDX50 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | -0.0268766 |
| RPLP2 | ribosomal protein, large, P2 | -0.0267888 |
| NAV2 | neuron navigator 2 | -0.0267696 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.02669 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0265263 |
| RPLP0 | ribosomal protein, large, P0 | -0.026234 |
| CAPRIN2 | caprin family member 2 | -0.0258123 |
| VMP1 | vacuole membrane protein 1 | -0.0256276 |
| SEC24A | SEC24 family member A | -0.0255665 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0254967 |
| USP34 | ubiquitin specific peptidase 34 | -0.025241 |
| RPS16 | ribosomal protein S16 | -0.0252354 |
| TMSB10 | thymosin beta 10 | -0.0251955 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0251777 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0250718 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0246784 |
| WDR26 | WD repeat domain 26 | -0.0246407 |
| RPL19 | ribosomal protein L19 | -0.0246213 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0239986 |
| WDR45B | WD repeat domain 45B | -0.0239457 |
| RPS29 | ribosomal protein S29 | -0.0236166 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0234659 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0234523 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0234122 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0231883 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0230486 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0225116 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0224859 |
| RPL37A | ribosomal protein L37a | -0.0224824 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0220766 |
| TMEM156 | transmembrane protein 156 | -0.0219237 |
