| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.220689 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.134712 |
| B2M | beta-2-microglobulin | 0.0974156 |
| MT2A | metallothionein 2A | 0.0755047 |
| ZNF292 | zinc finger protein 292 | 0.0656452 |
| COL1A2 | collagen, type I, alpha 2 | 0.0641366 |
| PGK1 | phosphoglycerate kinase 1 | 0.0593728 |
| NDRG1 | N-myc downstream regulated 1 | 0.0547137 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.054398 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0507299 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0500965 |
| PTMA | prothymosin, alpha | 0.0500467 |
| ANXA2 | annexin A2 | 0.0469966 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0451728 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0425511 |
| ENO1 | enolase 1, (alpha) | 0.0413639 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0411077 |
| GOLGA4 | golgin A4 | 0.0408976 |
| HLA-B | major histocompatibility complex, class I, B | 0.040846 |
| FTL | ferritin, light polypeptide | 0.0404455 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0391044 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0364716 |
| RPS8 | ribosomal protein S8 | 0.0363205 |
| CALR | calreticulin | 0.034831 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0343437 |
| RPS6 | ribosomal protein S6 | 0.0339838 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0335881 |
| SEPTIN7 | septin 7 | 0.0331658 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0330779 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0322132 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0321032 |
| LDHA | lactate dehydrogenase A | 0.0312745 |
| CD109 | CD109 molecule | 0.0312218 |
| RBM39 | RNA binding motif protein 39 | 0.0310129 |
| ADM | adrenomedullin | 0.0307391 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0300328 |
| XPO1 | exportin 1 | 0.029693 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0296381 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0293774 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0289796 |
| RPS12 | ribosomal protein S12 | 0.0282094 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0280432 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0277976 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0277512 |
| YBX1 | Y box binding protein 1 | 0.0273113 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0267662 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0263323 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0260459 |
| IFI44 | interferon-induced protein 44 | 0.0256383 |
| TFG | TRK-fused gene | 0.0256033 |
| ARRDC3 | arrestin domain containing 3 | 0.0255715 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0253352 |
| LMNA | lamin A/C | 0.0245458 |
| ANLN | anillin, actin binding protein | 0.0245322 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0243544 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0243142 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.02431 |
| RPS19 | ribosomal protein S19 | 0.0242327 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0241736 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0238422 |
| FAM13A | family with sequence similarity 13, member A | 0.0237168 |
| FAM162A | family with sequence similarity 162, member A | 0.0234822 |
| RPL35A | ribosomal protein L35a | 0.0233483 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0228642 |
| RPL11 | ribosomal protein L11 | 0.0227801 |
| RPLP1 | ribosomal protein, large, P1 | 0.02278 |
| PCBP2 | poly(rC) binding protein 2 | 0.0223509 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0223494 |
| FBXO32 | F-box protein 32 | 0.0221396 |
| RYBP | RING1 and YY1 binding protein | 0.0221298 |
| RPL12 | ribosomal protein L12 | 0.0219707 |
| HMGB2 | high mobility group box 2 | 0.0218891 |
| PKM | pyruvate kinase, muscle | 0.0216846 |
| CALU | calumenin | 0.0213804 |
| CENPF | centromere protein F, 350/400kDa | 0.0212586 |
| HLA-A | major histocompatibility complex, class I, A | 0.0208205 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0207887 |
| INSIG2 | insulin induced gene 2 | 0.0207633 |
| DSCAM | Down syndrome cell adhesion molecule | 0.020492 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0202508 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0200573 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0198819 |
| CALD1 | caldesmon 1 | 0.0198088 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0195952 |
| OPTN | optineurin | 0.0195333 |
| YEATS2 | YEATS domain containing 2 | 0.0195006 |
| OGA | O-GlcNAcase | 0.0194651 |
| ZNF148 | zinc finger protein 148 | 0.0191539 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0189075 |
| NUP58 | nucleoporin 58 | 0.0188572 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0186426 |
| RPS27A | ribosomal protein S27a | 0.0185944 |
| RTN4 | reticulon 4 | 0.0185586 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0185365 |
| RLF | rearranged L-myc fusion | 0.0184161 |
| SERINC1 | serine incorporator 1 | 0.0182949 |
| SPAG9 | sperm associated antigen 9 | 0.018146 |
| TPM3 | tropomyosin 3 | 0.0179795 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0179489 |
| GNAS | GNAS complex locus | 0.0179482 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.161104 |
| CDH13 | cadherin 13 | -0.0646029 |
| FRMD4A | FERM domain containing 4A | -0.0523965 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0476441 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0449974 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0432495 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0412566 |
| NAV1 | neuron navigator 1 | -0.0399052 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0385865 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0357437 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0336004 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0333077 |
| COL5A1 | collagen, type V, alpha 1 | -0.0323746 |
| HMGA2 | high mobility group AT-hook 2 | -0.0318072 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0314823 |
| GLIS3 | GLIS family zinc finger 3 | -0.0304881 |
| CD44 | CD44 molecule (Indian blood group) | -0.0298955 |
| ASPH | aspartate beta-hydroxylase | -0.0286666 |
| HPCAL1 | hippocalcin-like 1 | -0.0281237 |
| FAM20C | family with sequence similarity 20, member C | -0.027477 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0273979 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0269534 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0267171 |
| EGR1 | early growth response 1 | -0.0261524 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0259958 |
| NRP1 | neuropilin 1 | -0.0251997 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0247343 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -0.0241554 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0233101 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0229669 |
| SH3RF3 | SH3 domain containing ring finger 3 | -0.0228796 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0209302 |
| VCL | vinculin | -0.0201896 |
| TNS3 | tensin 3 | -0.020166 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0195125 |
| TNNC1 | troponin C type 1 (slow) | -0.0194812 |
| COL1A1 | collagen, type I, alpha 1 | -0.0189821 |
| PDE10A | phosphodiesterase 10A | -0.0187376 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0187222 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0185893 |
| EML5 | echinoderm microtubule associated protein like 5 | -0.0180968 |
| ACTN1 | actinin, alpha 1 | -0.0180557 |
| RUNX1 | runt-related transcription factor 1 | -0.0179785 |
| ITGA11 | integrin, alpha 11 | -0.0179194 |
| EGFR | epidermal growth factor receptor | -0.017549 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0174964 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0173173 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0172493 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0168574 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0165171 |
| INTS6 | integrator complex subunit 6 | -0.0164731 |
| COL5A3 | collagen, type V, alpha 3 | -0.0163391 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.01619 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0161153 |
| TOP1 | topoisomerase (DNA) I | -0.0158118 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0154668 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0152945 |
| VCAN | versican | -0.0152495 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0150505 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0150487 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.014888 |
| RAI14 | retinoic acid induced 14 | -0.0148498 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0148367 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | -0.0147119 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0146095 |
| NBEA | neurobeachin | -0.0144123 |
| ITGA1 | integrin, alpha 1 | -0.0141499 |
| SETX | senataxin | -0.014067 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0140542 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0140107 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0136568 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0136223 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0133999 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0131817 |
| USP34 | ubiquitin specific peptidase 34 | -0.0130668 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0129973 |
| ERBIN | erbb2 interacting protein | -0.0129609 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0129417 |
| CLMP | CXADR-like membrane protein | -0.0129364 |
| MTSS1 | metastasis suppressor 1 | -0.0129273 |
| ATM | ATM serine/threonine kinase | -0.012901 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0128164 |
| CCDC138 | coiled-coil domain containing 138 | -0.012814 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0128116 |
| MMP12 | matrix metallopeptidase 12 | -0.0128096 |
| TWIST2 | twist family bHLH transcription factor 2 | -0.0127644 |
| NF1 | neurofibromin 1 | -0.0127529 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0126637 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0125979 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0125045 |
| SP100 | SP100 nuclear antigen | -0.0124958 |
| MCL1 | myeloid cell leukemia 1 | -0.012455 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0123644 |
| SETBP1 | SET binding protein 1 | -0.0123189 |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | -0.0122837 |
| PCBP3 | poly(rC) binding protein 3 | -0.0122133 |
| RRBP1 | ribosome binding protein 1 | -0.0121728 |
| LOX | lysyl oxidase | -0.0121064 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0120896 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0120417 |
