| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0934075 |
| PEG10 | paternally expressed 10 | 0.0921861 |
| PTMA | prothymosin, alpha | 0.0913721 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0813179 |
| TENM1 | teneurin transmembrane protein 1 | 0.078676 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | 0.0764657 |
| CENPF | centromere protein F, 350/400kDa | 0.0689076 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0681928 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.062157 |
| SYT1 | synaptotagmin I | 0.0618999 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0574787 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0567431 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0564894 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0497711 |
| WWOX | WW domain containing oxidoreductase | 0.0441767 |
| ZNF292 | zinc finger protein 292 | 0.0440031 |
| PRKD1 | protein kinase D1 | 0.0435816 |
| DGKB | diacylglycerol kinase, beta 90kDa | 0.0433408 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.043117 |
| RALYL | RALY RNA binding protein-like | 0.0425017 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0415178 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0401923 |
| MED13L | mediator complex subunit 13-like | 0.0401446 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0398418 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0378449 |
| FAT1 | FAT atypical cadherin 1 | 0.0370996 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0367958 |
| NFIA | nuclear factor I/A | 0.0365611 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0364706 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0347822 |
| XPO1 | exportin 1 | 0.0346744 |
| RNF213 | ring finger protein 213 | 0.0346366 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.034584 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0343767 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0342056 |
| SMAD9 | SMAD family member 9 | 0.0341758 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0341215 |
| ADAR | adenosine deaminase, RNA-specific | 0.0341019 |
| MTMR7 | myotubularin related protein 7 | 0.0334694 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0332575 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0331275 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0329965 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.0320543 |
| ENO1 | enolase 1, (alpha) | 0.0317871 |
| STMN1 | stathmin 1 | 0.0304757 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0301468 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0300621 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0298454 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0297586 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0291472 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.029147 |
| PGK1 | phosphoglycerate kinase 1 | 0.0290218 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.029018 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0289901 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0286842 |
| TXNRD1 | thioredoxin reductase 1 | 0.0285873 |
| TPM3 | tropomyosin 3 | 0.0285809 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0279341 |
| FOXP2 | forkhead box P2 | 0.0276717 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0276369 |
| FTL | ferritin, light polypeptide | 0.0274492 |
| B2M | beta-2-microglobulin | 0.0263946 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0263676 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0262382 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0262317 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0260609 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0260204 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0257155 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0256409 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0251639 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0250445 |
| MATR3 | matrin 3 | 0.0250145 |
| KANTR | KDM5C adjacent non-coding transcript | 0.0247013 |
| KIAA0825 | KIAA0825 | 0.0245996 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0241915 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.024126 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.0238181 |
| SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | 0.0237879 |
| CCDC88A | coiled-coil domain containing 88A | 0.0237534 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0237229 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0235726 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0234235 |
| PCM1 | pericentriolar material 1 | 0.0233078 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0231832 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0231386 |
| NEBL | nebulette | 0.0228986 |
| PCBP2 | poly(rC) binding protein 2 | 0.0225981 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.0225205 |
| LDHA | lactate dehydrogenase A | 0.0223845 |
| MGAT4C | MGAT4 family, member C | 0.0223419 |
| HMGB2 | high mobility group box 2 | 0.0222329 |
| GPHN | gephyrin | 0.0221774 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0221245 |
| RTN4 | reticulon 4 | 0.0220885 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0220588 |
| SET | SET nuclear proto-oncogene | 0.0220039 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.0220033 |
| MKI67 | marker of proliferation Ki-67 | 0.0219786 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0216877 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0216704 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.163634 |
| NRG1 | neuregulin 1 | -0.156661 |
| GPC6 | glypican 6 | -0.154422 |
| MCL1 | myeloid cell leukemia 1 | -0.139904 |
| RORA | RAR-related orphan receptor A | -0.127659 |
| STC1 | stanniocalcin 1 | -0.100088 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0999016 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0996047 |
| NDRG1 | N-myc downstream regulated 1 | -0.0971248 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0946371 |
| PTCHD4 | patched domain containing 4 | -0.0916828 |
| EGR1 | early growth response 1 | -0.0861277 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0855241 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0844234 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.084231 |
| VGF | VGF nerve growth factor inducible | -0.082252 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0771752 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0734077 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.06842 |
| EFNA5 | ephrin-A5 | -0.0640641 |
| KIF26B | kinesin family member 26B | -0.0638405 |
| PDE10A | phosphodiesterase 10A | -0.062492 |
| SMYD3 | SET and MYND domain containing 3 | -0.0585699 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0573453 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.056972 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0552382 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0535486 |
| NAV2 | neuron navigator 2 | -0.052284 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0518095 |
| NBEA | neurobeachin | -0.0493384 |
| SNTG1 | syntrophin, gamma 1 | -0.047856 |
| CALCA | calcitonin-related polypeptide alpha | -0.0468757 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0459804 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0454168 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0450399 |
| KLHL29 | kelch-like family member 29 | -0.0448592 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0447868 |
| SETX | senataxin | -0.0441139 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0430617 |
| MAP1B | microtubule-associated protein 1B | -0.0420803 |
| TOP1 | topoisomerase (DNA) I | -0.0399134 |
| ESRRG | estrogen-related receptor gamma | -0.0395251 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0381767 |
| SCG2 | secretogranin II | -0.0375901 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0371892 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0370347 |
| GPC5 | glypican 5 | -0.0354476 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0352602 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0351644 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0347042 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0346965 |
| NANOS1 | nanos homolog 1 (Drosophila) | -0.0336381 |
| NELL1 | NEL-like 1 (chicken) | -0.0335545 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0329826 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0328915 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.032778 |
| INHBA | inhibin, beta A | -0.0327376 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0317478 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0314327 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0313522 |
| EPHA6 | EPH receptor A6 | -0.0313198 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0308945 |
| GOLGB1 | golgin B1 | -0.0299578 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0299119 |
| ACTG1 | actin gamma 1 | -0.0299034 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0295439 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.02923 |
| RGS17 | regulator of G-protein signaling 17 | -0.0291571 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0291407 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.0290261 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0288276 |
| TBC1D22A | TBC1 domain family, member 22A | -0.028638 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0282327 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0281912 |
| SCFD1 | sec1 family domain containing 1 | -0.0279377 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0279 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0274213 |
| CDK13 | cyclin-dependent kinase 13 | -0.0271417 |
| SVIL | supervillin | -0.027001 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0267727 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0267061 |
| ZFHX3 | zinc finger homeobox 3 | -0.0265058 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.0259644 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0258874 |
| SIK2 | salt-inducible kinase 2 | -0.0258155 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.0253373 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0246422 |
| HM13 | histocompatibility (minor) 13 | -0.0243271 |
| NF1 | neurofibromin 1 | -0.0239508 |
| VMP1 | vacuole membrane protein 1 | -0.0238405 |
| SERGEF | secretion regulating guanine nucleotide exchange factor | -0.0236723 |
| ARFGEF3 | ARFGEF family member 3 | -0.0235162 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0234844 |
| EGFR | epidermal growth factor receptor | -0.0234599 |
| PAEP | progestagen-associated endometrial protein | -0.0234437 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0234191 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0233933 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0228255 |
| SOBP | sine oculis binding protein homolog (Drosophila) | -0.0227319 |
| LSAMP | limbic system-associated membrane protein | -0.0224805 |
