| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.17898 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0960102 |
| NLGN1 | neuroligin 1 | 0.0942776 |
| GOLGA4 | golgin A4 | 0.0870878 |
| LSAMP | limbic system-associated membrane protein | 0.0812224 |
| FHIT | fragile histidine triad | 0.0786114 |
| SQSTM1 | sequestosome 1 | 0.0770065 |
| ZNF292 | zinc finger protein 292 | 0.0694287 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0676497 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.066954 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0628503 |
| MACROD2 | MACRO domain containing 2 | 0.0625661 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0623437 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0607053 |
| PRELID2 | PRELI domain containing 2 | 0.0603458 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0600372 |
| KLHL24 | kelch-like family member 24 | 0.0567972 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0551255 |
| SBF2 | SET binding factor 2 | 0.0545921 |
| CANX | calnexin | 0.0545264 |
| CENPF | centromere protein F, 350/400kDa | 0.0529911 |
| DST | dystonin | 0.0524632 |
| PMEL | premelanosome protein | 0.052264 |
| OGA | O-GlcNAcase | 0.0515141 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0506129 |
| BBX | bobby sox homolog (Drosophila) | 0.0490476 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0467875 |
| HELZ | helicase with zinc finger | 0.0458921 |
| QKI | QKI, KH domain containing, RNA binding | 0.0437154 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0434666 |
| PGK1 | phosphoglycerate kinase 1 | 0.0425642 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0424633 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0423167 |
| SFTPA2 | surfactant protein A2 | 0.0418602 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0414726 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0413877 |
| RAD51B | RAD51 paralog B | 0.0407655 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0401228 |
| CDK19 | cyclin-dependent kinase 19 | 0.0399841 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0395412 |
| B2M | beta-2-microglobulin | 0.0394782 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0391524 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0390218 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0385648 |
| ENO1 | enolase 1, (alpha) | 0.0383938 |
| YEATS2 | YEATS domain containing 2 | 0.0382107 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0376747 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0375524 |
| FTL | ferritin, light polypeptide | 0.0373393 |
| RNF213 | ring finger protein 213 | 0.0372656 |
| SMYD3 | SET and MYND domain containing 3 | 0.0372201 |
| PTMA | prothymosin, alpha | 0.0371843 |
| GPNMB | glycoprotein (transmembrane) nmb | 0.0369221 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.03684 |
| PRKD1 | protein kinase D1 | 0.0367935 |
| FAM13A | family with sequence similarity 13, member A | 0.0363729 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0358978 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.035667 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.0355615 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0354961 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0354513 |
| VIM | vimentin | 0.0350476 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.034974 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0348313 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0342288 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0341948 |
| SETD5 | SET domain containing 5 | 0.0341298 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.0340519 |
| AUTS2 | autism susceptibility candidate 2 | 0.0339411 |
| SPAG9 | sperm associated antigen 9 | 0.033645 |
| FNIP1 | folliculin interacting protein 1 | 0.0333289 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0328685 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0324781 |
| FMNL2 | formin-like 2 | 0.0323441 |
| PHF21A | PHD finger protein 21A | 0.0321066 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0320549 |
| RPS12 | ribosomal protein S12 | 0.0314149 |
| SORT1 | sortilin 1 | 0.0311408 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0302698 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.030112 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.030057 |
| CEP250 | centrosomal protein 250kDa | 0.0299763 |
| TRIM2 | tripartite motif containing 2 | 0.0298381 |
| PLP1 | proteolipid protein 1 | 0.0294229 |
| ANXA2 | annexin A2 | 0.0289778 |
| PCBP2 | poly(rC) binding protein 2 | 0.0288905 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0288552 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0283083 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0282951 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0281178 |
| PDZRN3 | PDZ domain containing ring finger 3 | 0.0280324 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0279514 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0276784 |
| ENAH | enabled homolog (Drosophila) | 0.0275955 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0274648 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0272607 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.0271869 |
| NBAS | neuroblastoma amplified sequence | 0.0270947 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0268459 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0268285 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.26213 |
| FMN1 | formin 1 | -0.19809 |
| NRG3 | neuregulin 3 | -0.136806 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.118325 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.106017 |
| CCND1 | cyclin D1 | -0.10351 |
| MT2A | metallothionein 2A | -0.099776 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0909972 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0740914 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0727963 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0722649 |
| CD44 | CD44 molecule (Indian blood group) | -0.0705281 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.059452 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0564411 |
| INPP5F | inositol polyphosphate-5-phosphatase F | -0.056037 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0556141 |
| CDK6 | cyclin-dependent kinase 6 | -0.0554369 |
| HDAC9 | histone deacetylase 9 | -0.0549074 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0548855 |
| ACTN1 | actinin, alpha 1 | -0.0540123 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0536556 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0507295 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0485339 |
| TMSB10 | thymosin beta 10 | -0.044868 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0445092 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0440206 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0428381 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0422053 |
| FRMD5 | FERM domain containing 5 | -0.0413439 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0407223 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0406901 |
| ANGPTL4 | angiopoietin-like 4 | -0.0406313 |
| CDH13 | cadherin 13 | -0.0399119 |
| HMGA1 | high mobility group AT-hook 1 | -0.0393337 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0386492 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0373792 |
| EMP1 | epithelial membrane protein 1 | -0.0370733 |
| EHBP1 | EH domain binding protein 1 | -0.0352321 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0350572 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0349694 |
| EXT1 | exostosin glycosyltransferase 1 | -0.034946 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0339424 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.033206 |
| SVIL | supervillin | -0.0329432 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0324696 |
| OPHN1 | oligophrenin 1 | -0.0317717 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0315806 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0312635 |
| DUSP6 | dual specificity phosphatase 6 | -0.0311766 |
| MT1X | metallothionein 1X | -0.030725 |
| USP53 | ubiquitin specific peptidase 53 | -0.030281 |
| STK10 | serine/threonine kinase 10 | -0.0300834 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.030024 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0298847 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0298213 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0296412 |
| ACTN4 | actinin, alpha 4 | -0.0294968 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0293034 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0291409 |
| TNNC1 | troponin C type 1 (slow) | -0.0288659 |
| MCL1 | myeloid cell leukemia 1 | -0.0287244 |
| RUNX1 | runt-related transcription factor 1 | -0.0277363 |
| POTEF | POTE ankyrin domain family, member F | -0.0273294 |
| NPAS2 | neuronal PAS domain protein 2 | -0.027133 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0270857 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0270241 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0269514 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0265216 |
| SMAD3 | SMAD family member 3 | -0.0262437 |
| NDRG1 | N-myc downstream regulated 1 | -0.0259644 |
| ITGB5 | integrin, beta 5 | -0.0258414 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0257721 |
| AMOTL1 | angiomotin like 1 | -0.0256917 |
| COMMD10 | COMM domain containing 10 | -0.0249647 |
| ZNF697 | zinc finger protein 697 | -0.0249023 |
| PTK2 | protein tyrosine kinase 2 | -0.0248507 |
| HPCAL1 | hippocalcin-like 1 | -0.0247788 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0245216 |
| IER3 | immediate early response 3 | -0.0242378 |
| MMP12 | matrix metallopeptidase 12 | -0.0241459 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0239942 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0239503 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0238961 |
| PKM | pyruvate kinase, muscle | -0.0238298 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0234372 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0232853 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0230119 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0229158 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0227914 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0227122 |
| PLAT | plasminogen activator, tissue | -0.0226702 |
| EGR1 | early growth response 1 | -0.0226473 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0226346 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0226019 |
| LAMB1 | laminin, beta 1 | -0.0222796 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0220436 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0219975 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0216347 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0215092 |
| PLEC | plectin | -0.0213919 |
