| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SSBP2 | single-stranded DNA binding protein 2 | 0.191912 |
| ZNF292 | zinc finger protein 292 | 0.119334 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.111056 |
| ANK2 | ankyrin 2, neuronal | 0.106567 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0917355 |
| PDGFC | platelet derived growth factor C | 0.0895521 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0870327 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.072394 |
| HDAC9 | histone deacetylase 9 | 0.0721304 |
| QKI | QKI, KH domain containing, RNA binding | 0.071074 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0708237 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0613148 |
| RBM39 | RNA binding motif protein 39 | 0.0608475 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0557195 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0553247 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0538062 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0531926 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.050972 |
| CDC73 | cell division cycle 73 | 0.0504225 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0495735 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0482533 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0480626 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0478426 |
| MEF2A | myocyte enhancer factor 2A | 0.0463056 |
| CCNL1 | cyclin L1 | 0.0462193 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0459144 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0451616 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0451039 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0443564 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0429958 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0415137 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0411124 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0409552 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0403581 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0387209 |
| EVI5 | ecotropic viral integration site 5 | 0.0385126 |
| DENND4A | DENN/MADD domain containing 4A | 0.0383679 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0381152 |
| GOLGA4 | golgin A4 | 0.0379393 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0377041 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0362584 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.035728 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0353477 |
| DAPK3 | death-associated protein kinase 3 | 0.0347934 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0345959 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0345581 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0342381 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0341965 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.0340768 |
| B2M | beta-2-microglobulin | 0.033608 |
| MSI2 | musashi RNA-binding protein 2 | 0.0335918 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0327361 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0322727 |
| OGA | O-GlcNAcase | 0.0322364 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0321932 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.031724 |
| RTN4 | reticulon 4 | 0.0315979 |
| NFIA | nuclear factor I/A | 0.030928 |
| WDR43 | WD repeat domain 43 | 0.0305147 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0304905 |
| SESN2 | sestrin 2 | 0.0302121 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0301341 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0300262 |
| GPHN | gephyrin | 0.0299934 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.029939 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0298191 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0296071 |
| FAM13A | family with sequence similarity 13, member A | 0.0295195 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0293921 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0291397 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.028786 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0286163 |
| PGK1 | phosphoglycerate kinase 1 | 0.0285915 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0283701 |
| MED13L | mediator complex subunit 13-like | 0.0281681 |
| NUP58 | nucleoporin 58 | 0.0281498 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0278283 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0277059 |
| NCKAP1 | NCK-associated protein 1 | 0.0275961 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0274291 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0272141 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0269777 |
| ZCCHC8 | zinc finger, CCHC domain containing 8 | 0.0268172 |
| USP3 | ubiquitin specific peptidase 3 | 0.0265169 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0263654 |
| RLF | rearranged L-myc fusion | 0.026323 |
| SPPL3 | signal peptide peptidase like 3 | 0.0259113 |
| PLCE1 | phospholipase C, epsilon 1 | 0.0255207 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0255181 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.025511 |
| TMEM41B | transmembrane protein 41B | 0.025281 |
| YTHDC1 | YTH domain containing 1 | 0.0248352 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0247781 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0246021 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0245717 |
| TXNL1 | thioredoxin-like 1 | 0.0245597 |
| CASC3 | cancer susceptibility candidate 3 | 0.0245295 |
| TFG | TRK-fused gene | 0.0244387 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0241572 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0241023 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.254071 |
| PKM | pyruvate kinase, muscle | -0.176863 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.155254 |
| AHNAK | AHNAK nucleoprotein | -0.14161 |
| PTMA | prothymosin, alpha | -0.130954 |
| FLNB | filamin B, beta | -0.115478 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0934 |
| BMP10 | bone morphogenetic protein 10 | -0.091898 |
| CCND1 | cyclin D1 | -0.0908654 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0879512 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0873788 |
| GLI3 | GLI family zinc finger 3 | -0.0838838 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.082745 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0776397 |
| EGFR | epidermal growth factor receptor | -0.0729823 |
| NBEA | neurobeachin | -0.0729396 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0623534 |
| GLI2 | GLI family zinc finger 2 | -0.0613206 |
| PYGB | phosphorylase, glycogen; brain | -0.0599212 |
| MYO5C | myosin VC | -0.0586251 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0561121 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.055368 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0535043 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0506016 |
| DUSP6 | dual specificity phosphatase 6 | -0.050207 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0491716 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0485271 |
| DUSP4 | dual specificity phosphatase 4 | -0.0484383 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0481888 |
| TBC1D22A | TBC1 domain family, member 22A | -0.047609 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.046473 |
| FOXP1 | forkhead box P1 | -0.0464068 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.0456249 |
| RPS27A | ribosomal protein S27a | -0.0450482 |
| LOXL3 | lysyl oxidase-like 3 | -0.0444852 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0433728 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0433404 |
| PIWIL1 | piwi-like RNA-mediated gene silencing 1 | -0.0432766 |
| BMP2K | BMP2 inducible kinase | -0.043227 |
| PRELID2 | PRELI domain containing 2 | -0.0431797 |
| GSE1 | Gse1 coiled-coil protein | -0.0429556 |
| EZR | ezrin | -0.0423456 |
| ZNF608 | zinc finger protein 608 | -0.0422667 |
| UBC | ubiquitin C | -0.0421163 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0412694 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0404745 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0404359 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0396406 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0394045 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0375506 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.037035 |
| S100A6 | S100 calcium binding protein A6 | -0.0367271 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0367138 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0364513 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0357447 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0357335 |
| RRBP1 | ribosome binding protein 1 | -0.0357165 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0338493 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0329502 |
| ACTG1 | actin gamma 1 | -0.0329442 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0326072 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0325537 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0324399 |
| ECT2 | epithelial cell transforming 2 | -0.0318639 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.031663 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0313376 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | -0.0312324 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.0310561 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0307989 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0300211 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0299727 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.029719 |
| NAV2 | neuron navigator 2 | -0.0287157 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.02827 |
| POTEF | POTE ankyrin domain family, member F | -0.0281065 |
| ASPH | aspartate beta-hydroxylase | -0.0274544 |
| BPTF | bromodomain PHD finger transcription factor | -0.0269944 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0269137 |
| ATP9B | ATPase, class II, type 9B | -0.0268726 |
| RPL4 | ribosomal protein L4 | -0.0262731 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0254439 |
| GPATCH2L | G patch domain containing 2-like | -0.0250857 |
| IRS1 | insulin receptor substrate 1 | -0.0246639 |
| HJURP | Holliday junction recognition protein | -0.0244695 |
| PFN1 | profilin 1 | -0.0243136 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.0241492 |
| FER1L6 | fer-1-like family member 6 | -0.0239462 |
| GOLGB1 | golgin B1 | -0.0239397 |
| S100A10 | S100 calcium binding protein A10 | -0.0238161 |
| PMM2 | phosphomannomutase 2 | -0.0235879 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0234879 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | -0.0234352 |
| ETV5 | ets variant 5 | -0.0233701 |
| INTS6 | integrator complex subunit 6 | -0.0232312 |
| PDE7B | phosphodiesterase 7B | -0.0228831 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0228157 |
| SEPTIN9 | septin 9 | -0.0227044 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0225015 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0223922 |
| TMSB10 | thymosin beta 10 | -0.0223314 |
