| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.145115 |
| FN1 | fibronectin 1 | 0.120618 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0846141 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0658905 |
| ARRDC3 | arrestin domain containing 3 | 0.058869 |
| ZNF292 | zinc finger protein 292 | 0.0585539 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0566008 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0533685 |
| OGA | O-GlcNAcase | 0.0528546 |
| ANLN | anillin, actin binding protein | 0.0452966 |
| WTAP | Wilms tumor 1 associated protein | 0.0450977 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0417051 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0415903 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0388092 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0368638 |
| RPS12 | ribosomal protein S12 | 0.0366019 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0361467 |
| COL1A2 | collagen, type I, alpha 2 | 0.0360054 |
| THBS1 | thrombospondin 1 | 0.0359502 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0337485 |
| MKI67 | marker of proliferation Ki-67 | 0.0322092 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0319295 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0318856 |
| KLF6 | Kruppel-like factor 6 | 0.0304685 |
| TXNIP | thioredoxin interacting protein | 0.0303516 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0303448 |
| SFTPA2 | surfactant protein A2 | 0.0292601 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0290577 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0281883 |
| RPL12 | ribosomal protein L12 | 0.028035 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0275062 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0274471 |
| OPTN | optineurin | 0.027187 |
| RPS3 | ribosomal protein S3 | 0.0267403 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.026457 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0258187 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0253037 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0244673 |
| SBF2 | SET binding factor 2 | 0.0242604 |
| SMYD3 | SET and MYND domain containing 3 | 0.024062 |
| KIF4A | kinesin family member 4A | 0.0237807 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0235067 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0234238 |
| SERINC1 | serine incorporator 1 | 0.0230538 |
| FLNA | filamin A, alpha | 0.0230495 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | 0.0223252 |
| YBX1 | Y box binding protein 1 | 0.0220406 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.021974 |
| BICC1 | BicC family RNA binding protein 1 | 0.0216917 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0215681 |
| PGK1 | phosphoglycerate kinase 1 | 0.0214394 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0212191 |
| FBXO32 | F-box protein 32 | 0.0205877 |
| SDC4 | syndecan 4 | 0.0203362 |
| SRGN | serglycin | 0.0201014 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0199441 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0199194 |
| GANAB | glucosidase, alpha; neutral AB | 0.0198965 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0193414 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0191208 |
| RPS2 | ribosomal protein S2 | 0.0190703 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0189749 |
| DENND2B | DENN domain containing 2B | 0.018815 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0183719 |
| SLK | STE20-like kinase | 0.0183382 |
| KIAA1958 | KIAA1958 | 0.0181956 |
| ZNF608 | zinc finger protein 608 | 0.0181573 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | 0.0177615 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0174179 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0174078 |
| MYOF | myoferlin | 0.0173547 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0169782 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0169437 |
| PHF3 | PHD finger protein 3 | 0.0169433 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0169209 |
| TMF1 | TATA element modulatory factor 1 | 0.0168916 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0168222 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0167485 |
| SQSTM1 | sequestosome 1 | 0.0166787 |
| ADM | adrenomedullin | 0.0166344 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0165542 |
| MED14 | mediator complex subunit 14 | 0.0163738 |
| ANXA2 | annexin A2 | 0.0163192 |
| CUL5 | cullin 5 | 0.0163152 |
| AFAP1 | actin filament associated protein 1 | 0.0161006 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0160729 |
| SET | SET nuclear proto-oncogene | 0.0160384 |
| TGFB2 | transforming growth factor, beta 2 | 0.0158507 |
| CDK19 | cyclin-dependent kinase 19 | 0.0153874 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0153278 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0151966 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0150558 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0150309 |
| PHIP | pleckstrin homology domain interacting protein | 0.0149365 |
| CUL4B | cullin 4B | 0.0149221 |
| SDCBP | syndecan binding protein (syntenin) | 0.0148896 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0147678 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0147504 |
| STAG2 | stromal antigen 2 | 0.01474 |
| CENPF | centromere protein F, 350/400kDa | 0.0147173 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.137868 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.131574 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0861259 |
| IER3 | immediate early response 3 | -0.0852115 |
| FTL | ferritin, light polypeptide | -0.0849819 |
| TMSB10 | thymosin beta 10 | -0.0784307 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0716698 |
| EGR1 | early growth response 1 | -0.0714443 |
| CD44 | CD44 molecule (Indian blood group) | -0.0686894 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.068219 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0625463 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0572613 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0572454 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0567486 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0540483 |
| CDH13 | cadherin 13 | -0.0499285 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0456173 |
| GLIS3 | GLIS family zinc finger 3 | -0.0442415 |
| EGFR | epidermal growth factor receptor | -0.0437771 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0426124 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0421577 |
| NDRG1 | N-myc downstream regulated 1 | -0.0419983 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0410064 |
| RND3 | Rho family GTPase 3 | -0.0393884 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0393082 |
| HMGA2 | high mobility group AT-hook 2 | -0.0392192 |
| PKM | pyruvate kinase, muscle | -0.0374873 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0374261 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0370018 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.036755 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0364055 |
| RPL31 | ribosomal protein L31 | -0.0362561 |
| INTS6 | integrator complex subunit 6 | -0.0360167 |
| ASPH | aspartate beta-hydroxylase | -0.0358269 |
| PLIN2 | perilipin 2 | -0.0357673 |
| RPS24 | ribosomal protein S24 | -0.03558 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0347408 |
| HDAC9 | histone deacetylase 9 | -0.0342027 |
| DIAPH2 | diaphanous-related formin 2 | -0.0338362 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0336749 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | -0.0333502 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0325999 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0316423 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0305013 |
| HMGA1 | high mobility group AT-hook 1 | -0.0302303 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0298819 |
| CTSD | cathepsin D | -0.0296604 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0293461 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0290838 |
| HLA-B | major histocompatibility complex, class I, B | -0.0283992 |
| SEC24A | SEC24 family member A | -0.0283576 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0283567 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0280303 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0279052 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0277194 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0273285 |
| FBXO11 | F-box protein 11 | -0.0272614 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0272431 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0269987 |
| MYO10 | myosin X | -0.0268657 |
| GOLGB1 | golgin B1 | -0.0266947 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0266463 |
| VMP1 | vacuole membrane protein 1 | -0.0263907 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0263768 |
| VCL | vinculin | -0.0263394 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0260469 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0259401 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.025822 |
| ATXN1 | ataxin 1 | -0.0256408 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0255069 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0252507 |
| NAV1 | neuron navigator 1 | -0.0250762 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0250352 |
| MORF4L2 | mortality factor 4 like 2 | -0.0250256 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0248954 |
| RPL23 | ribosomal protein L23 | -0.0248492 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0246992 |
| LOX | lysyl oxidase | -0.0240533 |
| TMEM132D | transmembrane protein 132D | -0.0240266 |
| RPLP1 | ribosomal protein, large, P1 | -0.0238284 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0234658 |
| MMP12 | matrix metallopeptidase 12 | -0.0231385 |
| RPL35A | ribosomal protein L35a | -0.0231345 |
| RPS23 | ribosomal protein S23 | -0.0228731 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0227491 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0226845 |
| TLE4 | transducin-like enhancer of split 4 | -0.0225036 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0222176 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0219684 |
| SP100 | SP100 nuclear antigen | -0.0217939 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0217561 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0217525 |
| JMJD1C | jumonji domain containing 1C | -0.0217436 |
| NABP1 | nucleic acid binding protein 1 | -0.021609 |
| RPL28 | ribosomal protein L28 | -0.0211588 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0210792 |
| RNF213 | ring finger protein 213 | -0.0209615 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0209561 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0209493 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0208347 |
