| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.242471 |
| ARRDC3 | arrestin domain containing 3 | 0.116355 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0959844 |
| B2M | beta-2-microglobulin | 0.0942338 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.091316 |
| COL5A2 | collagen, type V, alpha 2 | 0.0893899 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0849007 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.079716 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0781653 |
| COL1A2 | collagen, type I, alpha 2 | 0.0780352 |
| ADM | adrenomedullin | 0.0770977 |
| CALR | calreticulin | 0.0743468 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0740377 |
| OGA | O-GlcNAcase | 0.0663363 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0633676 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0631699 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.060588 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0575264 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0569923 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0568215 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0565337 |
| ZNF292 | zinc finger protein 292 | 0.0562137 |
| MEF2A | myocyte enhancer factor 2A | 0.0553672 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0536868 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0531285 |
| CANX | calnexin | 0.0523998 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.051895 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.051229 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0446125 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0431649 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.04257 |
| SMAD3 | SMAD family member 3 | 0.0422745 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0420005 |
| MYOF | myoferlin | 0.0416809 |
| USP48 | ubiquitin specific peptidase 48 | 0.041626 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0414817 |
| COL1A1 | collagen, type I, alpha 1 | 0.0405318 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0398674 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0392252 |
| ANXA2 | annexin A2 | 0.0380958 |
| COG5 | component of oligomeric golgi complex 5 | 0.0372369 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0367917 |
| FAM13A | family with sequence similarity 13, member A | 0.0348424 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0346884 |
| NRXN3 | neurexin 3 | 0.0346216 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0342665 |
| ATP13A3 | ATPase type 13A3 | 0.0334926 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0331326 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0326434 |
| PTN | pleiotrophin | 0.0319705 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0317278 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0317127 |
| AUTS2 | autism susceptibility candidate 2 | 0.0315972 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0313589 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0309596 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0307643 |
| DENND5A | DENN/MADD domain containing 5A | 0.0306829 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0305709 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.030085 |
| H3-3B | H3.3 histone B | 0.0300008 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0298771 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0298752 |
| TVP23C-CDRT4 | TVP23C-CDRT4 readthrough | 0.0296192 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0293125 |
| AHNAK | AHNAK nucleoprotein | 0.0287525 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0286898 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.028532 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0283243 |
| RNF24 | ring finger protein 24 | 0.0282957 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.027984 |
| COL3A1 | collagen, type III, alpha 1 | 0.0279094 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0277793 |
| TFG | TRK-fused gene | 0.0276266 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0275903 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0275439 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0274592 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0274435 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.027433 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.027253 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0272187 |
| ANXA1 | annexin A1 | 0.0268893 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0266811 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0265968 |
| RASA2 | RAS p21 protein activator 2 | 0.026469 |
| PREPL | prolyl endopeptidase-like | 0.0264582 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0264556 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0264454 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0263456 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0259066 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0258893 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.025376 |
| TRAPPC11 | trafficking protein particle complex 11 | 0.0248394 |
| SECISBP2L | SECIS binding protein 2-like | 0.0248071 |
| INSIG2 | insulin induced gene 2 | 0.0247351 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.0246608 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0246415 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0245669 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0244646 |
| SOCS5 | suppressor of cytokine signaling 5 | 0.0242024 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.024187 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.275175 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.144887 |
| VIM | vimentin | -0.134161 |
| TMSB10 | thymosin beta 10 | -0.115749 |
| FN1 | fibronectin 1 | -0.10742 |
| CDH13 | cadherin 13 | -0.102567 |
| MT2A | metallothionein 2A | -0.0972292 |
| IL6 | interleukin 6 | -0.0880202 |
| POTEF | POTE ankyrin domain family, member F | -0.0836793 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0755949 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0752448 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0736421 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0704822 |
| STC1 | stanniocalcin 1 | -0.0665144 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0634483 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0592394 |
| PKM | pyruvate kinase, muscle | -0.0514781 |
| EGR1 | early growth response 1 | -0.0487757 |
| RUNX1 | runt-related transcription factor 1 | -0.0479154 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0476964 |
| ECE1 | endothelin converting enzyme 1 | -0.0468914 |
| GLIS3 | GLIS family zinc finger 3 | -0.0465541 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0447128 |
| HM13 | histocompatibility (minor) 13 | -0.0438719 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0427873 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0418373 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0410382 |
| ACTG1 | actin gamma 1 | -0.0394911 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0388415 |
| HMGA2 | high mobility group AT-hook 2 | -0.0385522 |
| FTL | ferritin, light polypeptide | -0.0381135 |
| MYO1E | myosin IE | -0.0370574 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0362888 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0350182 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0349932 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0328567 |
| MCL1 | myeloid cell leukemia 1 | -0.03246 |
| RPLP1 | ribosomal protein, large, P1 | -0.0323758 |
| LSAMP | limbic system-associated membrane protein | -0.0321716 |
| RAI14 | retinoic acid induced 14 | -0.0317856 |
| RPL35A | ribosomal protein L35a | -0.0316221 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0311105 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0308618 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.030387 |
| CDK6 | cyclin-dependent kinase 6 | -0.0300999 |
| TOP1 | topoisomerase (DNA) I | -0.0300961 |
| ANLN | anillin, actin binding protein | -0.0293935 |
| LDHA | lactate dehydrogenase A | -0.029369 |
| TNS3 | tensin 3 | -0.0292861 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0292214 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0292123 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0292071 |
| LAMB3 | laminin, beta 3 | -0.0289378 |
| VCL | vinculin | -0.028762 |
| INTS6 | integrator complex subunit 6 | -0.0281286 |
| NAV2 | neuron navigator 2 | -0.0278914 |
| GLG1 | golgi glycoprotein 1 | -0.0277434 |
| TPM1 | tropomyosin 1 (alpha) | -0.0272599 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.027159 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0270883 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0269342 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0266421 |
| PRSS23 | protease, serine, 23 | -0.0262431 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0262121 |
| CBX3 | chromobox homolog 3 | -0.0258901 |
| RPL37 | ribosomal protein L37 | -0.0258608 |
| BRD2 | bromodomain containing 2 | -0.0257215 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0256548 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0254598 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0253261 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.025153 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0250538 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0249336 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0247756 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0246246 |
| CUL4A | cullin 4A | -0.0246047 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0244807 |
| RPL11 | ribosomal protein L11 | -0.0243725 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0239268 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0238136 |
| NABP1 | nucleic acid binding protein 1 | -0.0237656 |
| FAM107B | family with sequence similarity 107, member B | -0.0237421 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.023695 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0234991 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0234447 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0234365 |
| PARD3 | par-3 family cell polarity regulator | -0.0234184 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0234015 |
| LOX | lysyl oxidase | -0.0234012 |
| RRBP1 | ribosome binding protein 1 | -0.0231766 |
| SEPTIN2 | septin 2 | -0.0231033 |
| NAV1 | neuron navigator 1 | -0.0228429 |
| SON | SON DNA binding protein | -0.0228291 |
| COL5A1 | collagen, type V, alpha 1 | -0.0228047 |
| SP100 | SP100 nuclear antigen | -0.0226981 |
| CSNK1E | casein kinase 1, epsilon | -0.0226145 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0224124 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0223078 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0221652 |
| MTDH | metadherin | -0.0221021 |
