| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.0626027 |
| ZNF292 | zinc finger protein 292 | 0.0586171 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0567136 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0491784 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0491661 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0484713 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0440146 |
| WAC | WW domain containing adaptor with coiled-coil | 0.043878 |
| NUP58 | nucleoporin 58 | 0.0433941 |
| PCBP2 | poly(rC) binding protein 2 | 0.0415869 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0409185 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0408977 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0398083 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0389473 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0375633 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0367246 |
| ANXA1 | annexin A1 | 0.035193 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0345684 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0345581 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0341163 |
| ANLN | anillin, actin binding protein | 0.0340938 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0339199 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0335683 |
| ARRDC3 | arrestin domain containing 3 | 0.0332006 |
| TFG | TRK-fused gene | 0.0328237 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0327785 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0326196 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0325145 |
| TNPO1 | transportin 1 | 0.0323393 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0316076 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0314841 |
| COLEC11 | collectin sub-family member 11 | 0.0311891 |
| CEP250 | centrosomal protein 250kDa | 0.0307958 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.029897 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0295576 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0289873 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0289032 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0286391 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0278522 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0276471 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0274982 |
| SPAG9 | sperm associated antigen 9 | 0.0269632 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0268755 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0268515 |
| PAPOLA | poly(A) polymerase alpha | 0.0267118 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0262344 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0257478 |
| TPX2 | TPX2, microtubule-associated | 0.0255825 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0249318 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0248161 |
| QKI | QKI, KH domain containing, RNA binding | 0.024259 |
| NBAS | neuroblastoma amplified sequence | 0.0242426 |
| USP37 | ubiquitin specific peptidase 37 | 0.0241529 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0240402 |
| DEK | DEK proto-oncogene | 0.0240014 |
| CENPF | centromere protein F, 350/400kDa | 0.0239737 |
| CCNG2 | cyclin G2 | 0.0238847 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0238764 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0238327 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0236032 |
| ZNF451 | zinc finger protein 451 | 0.0235471 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0234849 |
| CUL4B | cullin 4B | 0.0233153 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0232267 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0230155 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0229766 |
| SQSTM1 | sequestosome 1 | 0.0229269 |
| PER1 | period circadian clock 1 | 0.0229209 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0228447 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0227624 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.02274 |
| SET | SET nuclear proto-oncogene | 0.0225931 |
| OGA | O-GlcNAcase | 0.0225341 |
| NUP153 | nucleoporin 153kDa | 0.0224829 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0222946 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.022199 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0221578 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0219766 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0218249 |
| FAM13A | family with sequence similarity 13, member A | 0.0217809 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.0217256 |
| XPO1 | exportin 1 | 0.0217246 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0216182 |
| RHEB | Ras homolog enriched in brain | 0.0215874 |
| PRELID2 | PRELI domain containing 2 | 0.0215815 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0215225 |
| UBQLN1 | ubiquilin 1 | 0.0213943 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0213735 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0213577 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.021304 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0212335 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0211667 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0209634 |
| SLMAP | sarcolemma associated protein | 0.0208948 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0208164 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0207444 |
| STAG2 | stromal antigen 2 | 0.0206884 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0206703 |
| AURKA | aurora kinase A | 0.0204988 |
| CDC27 | cell division cycle 27 | 0.0204318 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.238359 |
| VIM | vimentin | -0.148976 |
| CD44 | CD44 molecule (Indian blood group) | -0.131462 |
| FNDC3B | fibronectin type III domain containing 3B | -0.1272 |
| TMSB10 | thymosin beta 10 | -0.115967 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.113841 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0995978 |
| HMGA2 | high mobility group AT-hook 2 | -0.0967955 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0921207 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0920833 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0897722 |
| OSMR | oncostatin M receptor | -0.0879465 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0854239 |
| LDHA | lactate dehydrogenase A | -0.0849063 |
| FMNL2 | formin-like 2 | -0.0733048 |
| ANGPTL4 | angiopoietin-like 4 | -0.07293 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0676477 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0663156 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0645825 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0641465 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0628434 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0622726 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0615942 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0610772 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0607034 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0603743 |
| NF1 | neurofibromin 1 | -0.0591949 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0589873 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0583005 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.056924 |
| ATM | ATM serine/threonine kinase | -0.0565235 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0544022 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0525053 |
| MT2A | metallothionein 2A | -0.0523291 |
| FMN1 | formin 1 | -0.052163 |
| FLNB | filamin B, beta | -0.0520471 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0516679 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.049989 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0499191 |
| POTEF | POTE ankyrin domain family, member F | -0.0486387 |
| VCL | vinculin | -0.0484047 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0480284 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0479355 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0479003 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0450048 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0446192 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0445399 |
| EGR1 | early growth response 1 | -0.044289 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0442797 |
| NAV3 | neuron navigator 3 | -0.0439984 |
| ACER3 | alkaline ceramidase 3 | -0.0437778 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0435223 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0418895 |
| PKM | pyruvate kinase, muscle | -0.0414351 |
| HDAC9 | histone deacetylase 9 | -0.0414325 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0414256 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0412188 |
| SVIL | supervillin | -0.0411498 |
| ASPH | aspartate beta-hydroxylase | -0.0407842 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0404764 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0403788 |
| NALCN | sodium leak channel, non selective | -0.0403686 |
| MCL1 | myeloid cell leukemia 1 | -0.0402586 |
| EFNA5 | ephrin-A5 | -0.0392408 |
| CDCP1 | CUB domain containing protein 1 | -0.0390947 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0390656 |
| RAI14 | retinoic acid induced 14 | -0.0388688 |
| SDC4 | syndecan 4 | -0.0388645 |
| ACTG1 | actin gamma 1 | -0.0387991 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0376537 |
| BPTF | bromodomain PHD finger transcription factor | -0.0373581 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0373294 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0373008 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0369359 |
| ERBIN | erbb2 interacting protein | -0.0365976 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0365771 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0365589 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0365156 |
| IGF2 | insulin-like growth factor 2 | -0.0365041 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0364023 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0362597 |
| AHNAK | AHNAK nucleoprotein | -0.0357528 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0353962 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0353825 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0352118 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0348806 |
| PLEK2 | pleckstrin 2 | -0.0345656 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0342317 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0341432 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0339652 |
| DNER | delta/notch-like EGF repeat containing | -0.0338665 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0338456 |
| PRSS23 | protease, serine, 23 | -0.0335809 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0335622 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0334096 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0332842 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0332769 |
| ATG7 | autophagy related 7 | -0.032954 |
| GPATCH2L | G patch domain containing 2-like | -0.0329367 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.032662 |
