Trametinib (DMSO_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib (DMSO perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib (DMSO_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.276725
SQSTM1 sequestosome 1 0.0872183
NAMPT nicotinamide phosphoribosyltransferase 0.0865901
B2M beta-2-microglobulin 0.0798188
PTMA prothymosin, alpha 0.0797346
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.078897
VIM vimentin 0.0717484
SOD2 superoxide dismutase 2, mitochondrial 0.0670556
FTL ferritin, light polypeptide 0.066868
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0660306
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0657144
FTH1 ferritin, heavy polypeptide 1 0.0651831
CANX calnexin 0.0646391
HLA-B major histocompatibility complex, class I, B 0.0623725
FNDC3B fibronectin type III domain containing 3B 0.0617551
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0606761
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0585824
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0575662
CD109 CD109 molecule 0.057084
SFTPA2 surfactant protein A2 0.0561406
RPS12 ribosomal protein S12 0.0553329
TPT1 tumor protein, translationally-controlled 1 0.0534868
RPS6 ribosomal protein S6 0.0519852
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0513766
TRIO trio Rho guanine nucleotide exchange factor 0.0504014
ENO1 enolase 1, (alpha) 0.0488483
MT2A metallothionein 2A 0.0483653
S100A6 S100 calcium binding protein A6 0.047883
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0471217
EXT1 exostosin glycosyltransferase 1 0.0468242
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0453914
RPL26 ribosomal protein L26 0.0444515
FAM13A family with sequence similarity 13, member A 0.0435738
ZNF292 zinc finger protein 292 0.0431547
PELI1 pellino E3 ubiquitin protein ligase 1 0.0420429
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.042011
TXNIP thioredoxin interacting protein 0.0415354
EPS8 epidermal growth factor receptor pathway substrate 8 0.0414787
NAP1L1 nucleosome assembly protein 1-like 1 0.0398883
RPL12 ribosomal protein L12 0.039384
PRRC2C proline-rich coiled-coil 2C 0.0391778
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0389882
RACK1 receptor for activated C kinase 1 0.0388858
RPL37A ribosomal protein L37a 0.038856
RPS27 ribosomal protein S27 0.0387127
CFB complement factor B 0.0386508
RPS19 ribosomal protein S19 0.0385949
TXNRD1 thioredoxin reductase 1 0.0385533
DST dystonin 0.038453
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0382931
KTN1 kinectin 1 (kinesin receptor) 0.0366999
LIFR leukemia inhibitory factor receptor alpha 0.0362111
RPS8 ribosomal protein S8 0.036098
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0360294
CALR calreticulin 0.0357633
MGST1 microsomal glutathione S-transferase 1 0.0352958
UGCG UDP-glucose ceramide glucosyltransferase 0.0343967
RUNX2 runt-related transcription factor 2 0.034116
GPC6 glypican 6 0.0340009
RPL35A ribosomal protein L35a 0.0336635
OGA O-GlcNAcase 0.0334366
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0330878
ENAH enabled homolog (Drosophila) 0.0329526
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0324395
OSMR oncostatin M receptor 0.031875
TPI1 triosephosphate isomerase 1 0.0315876
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0314936
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0314205
AHR aryl hydrocarbon receptor 0.0313307
RPL23 ribosomal protein L23 0.0308182
YBX3 Y box binding protein 3 0.030336
RPS29 ribosomal protein S29 0.0303279
RPL9 ribosomal protein L9 0.030236
RPL11 ribosomal protein L11 0.0301245
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0300048
PTGR1 prostaglandin reductase 1 0.0300041
WAC WW domain containing adaptor with coiled-coil 0.0296159
IFI6 interferon, alpha-inducible protein 6 0.0294929
ARRDC3 arrestin domain containing 3 0.0292266
ELL2 elongation factor, RNA polymerase II, 2 0.0290949
RPS3 ribosomal protein S3 0.0289665
RPS27A ribosomal protein S27a 0.0287774
HLA-A major histocompatibility complex, class I, A 0.0286438
S100A10 S100 calcium binding protein A10 0.0285893
RPLP1 ribosomal protein, large, P1 0.028431
BIRC3 baculoviral IAP repeat containing 3 0.0282392
THBS1 thrombospondin 1 0.02823
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0276901
EIF1 eukaryotic translation initiation factor 1 0.0274805
ANKRD28 ankyrin repeat domain 28 0.0266487
RPL37 ribosomal protein L37 0.0266298
PLIN2 perilipin 2 0.0264959
DSCAM Down syndrome cell adhesion molecule 0.0261672
KMT2E lysine (K)-specific methyltransferase 2E 0.0259651
RAB1A RAB1A, member RAS oncogene family 0.0258591
RPL36 ribosomal protein L36 0.0254894
PGK1 phosphoglycerate kinase 1 0.0250109
RPL19 ribosomal protein L19 0.0247746
IFI27 interferon, alpha-inducible protein 27 0.024669
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0244559

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.206519
NRG1 neuregulin 1 -0.174623
HMGA2 high mobility group AT-hook 2 -0.149124
ITGA1 integrin, alpha 1 -0.0889999
EFNA5 ephrin-A5 -0.0607323
GLIS3 GLIS family zinc finger 3 -0.0569448
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0501058
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0473121
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0459289
FN1 fibronectin 1 -0.0457018
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0438111
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0385607
TMEM156 transmembrane protein 156 -0.0359781
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0351475
NPAS2 neuronal PAS domain protein 2 -0.0311051
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0289251
SYT1 synaptotagmin I -0.0279623
VCL vinculin -0.0255971
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0246013
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.024393
HPCAL1 hippocalcin-like 1 -0.0243127
GRB10 growth factor receptor-bound protein 10 -0.0217548
NRP1 neuropilin 1 -0.0212234
ETV1 ets variant 1 -0.0212048
AHRR aryl-hydrocarbon receptor repressor -0.0202291
EGR1 early growth response 1 -0.0201764
TSC22D1 TSC22 domain family, member 1 -0.0195474
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0191825
FAM3C family with sequence similarity 3, member C -0.0190905
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0188533
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0188224
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0181091
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0180414
PDLIM5 PDZ and LIM domain 5 -0.018009
FAM20C family with sequence similarity 20, member C -0.0176244
AGO2 argonaute RISC catalytic component 2 -0.0175231
BICD1 bicaudal D homolog 1 (Drosophila) -0.017457
ACTN1 actinin, alpha 1 -0.0173275
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.016938
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0169094
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0164286
TOP1 topoisomerase (DNA) I -0.0164232
MCTP2 multiple C2 domains, transmembrane 2 -0.0161711
DUSP6 dual specificity phosphatase 6 -0.0160714
INTS6 integrator complex subunit 6 -0.0160069
TGFB1 transforming growth factor, beta 1 -0.0159029
UBASH3B ubiquitin associated and SH3 domain containing B -0.0154821
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0154143
TGFA transforming growth factor, alpha -0.0150381
RAI14 retinoic acid induced 14 -0.0150211
SHB Src homology 2 domain containing adaptor protein B -0.0142645
AEBP2 AE binding protein 2 -0.0141608
COPA coatomer protein complex, subunit alpha -0.0140858
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0138054
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0135787
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0133527
ITGB5 integrin, beta 5 -0.013213
ZC3H12C zinc finger CCCH-type containing 12C -0.0131806
ETV5 ets variant 5 -0.0127908
CTBP2 C-terminal binding protein 2 -0.0127291
SLC35F3 solute carrier family 35, member F3 -0.0126712
NAV1 neuron navigator 1 -0.0125906
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0124919
SCFD2 sec1 family domain containing 2 -0.012375
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 -0.0123167
PELO pelota homolog (Drosophila) -0.0121753
VEGFC vascular endothelial growth factor C -0.0120576
LOC102724023 ES1 protein homolog, mitochondrial -0.0119876
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0119536
MYO10 myosin X -0.0116989
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0116834
FHL2 four and a half LIM domains 2 -0.0115092
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0114483
TTC19 tetratricopeptide repeat domain 19 -0.0114077
NTN4 netrin 4 -0.0113607
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0112277
GOLGA3 golgin A3 -0.0111973
DUSP5 dual specificity phosphatase 5 -0.0111437
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0111222
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0110968
DNAH5 dynein, axonemal, heavy chain 5 -0.0110669
ATP9A ATPase, class II, type 9A -0.0110657
ZFYVE28 zinc finger, FYVE domain containing 28 -0.0107584
CD44 CD44 molecule (Indian blood group) -0.0106323
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0106304
MTSS1 metastasis suppressor 1 -0.010624
MCTP1 multiple C2 domains, transmembrane 1 -0.0106228
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0106203
ATG7 autophagy related 7 -0.010591
CEMIP2 cell migration inducing hyaluronidase 2 -0.0105746
USP34 ubiquitin specific peptidase 34 -0.010537
CCDC138 coiled-coil domain containing 138 -0.0104987
BAIAP2 BAI1-associated protein 2 -0.0103432
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0103126
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0102773
PRKCA protein kinase C, alpha -0.0102673
SETX senataxin -0.0101505
DHFR dihydrofolate reductase -0.0100357
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.00999325
ABR active BCR-related -0.00989578