| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.110372 |
| PTMA | prothymosin, alpha | 0.0926884 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0873647 |
| DSPP | dentin sialophosphoprotein | 0.0770538 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0747529 |
| B2M | beta-2-microglobulin | 0.0680924 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0638477 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0633681 |
| PGK1 | phosphoglycerate kinase 1 | 0.0514683 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0505878 |
| PCBP2 | poly(rC) binding protein 2 | 0.0491764 |
| RNF213 | ring finger protein 213 | 0.0465396 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0440019 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0435042 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.04346 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0432278 |
| ADM | adrenomedullin | 0.0428254 |
| SUCO | SUN domain containing ossification factor | 0.0425369 |
| NDRG1 | N-myc downstream regulated 1 | 0.0420486 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0415199 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0414935 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0412085 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0403272 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0397735 |
| DST | dystonin | 0.0387492 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0384402 |
| CD47 | CD47 molecule | 0.0379748 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0356686 |
| AHNAK | AHNAK nucleoprotein | 0.0348072 |
| KRT19 | keratin 19, type I | 0.0346344 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0344756 |
| XPO1 | exportin 1 | 0.0338974 |
| CANX | calnexin | 0.0335815 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0331565 |
| NCKAP1 | NCK-associated protein 1 | 0.0330572 |
| OGA | O-GlcNAcase | 0.0328259 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0320754 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.031888 |
| KRT18 | keratin 18, type I | 0.0317985 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0316017 |
| USP3 | ubiquitin specific peptidase 3 | 0.0315635 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0315319 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0315147 |
| CALR | calreticulin | 0.0314511 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0313632 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0311745 |
| ANXA2 | annexin A2 | 0.0308239 |
| BBX | bobby sox homolog (Drosophila) | 0.0306292 |
| ZNF292 | zinc finger protein 292 | 0.0305157 |
| ZNF148 | zinc finger protein 148 | 0.0298107 |
| CD9 | CD9 molecule | 0.0298019 |
| ATP9A | ATPase, class II, type 9A | 0.0297285 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0297153 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0297023 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0295776 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0295195 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0290925 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0288443 |
| PRELID2 | PRELI domain containing 2 | 0.0287098 |
| RPL12 | ribosomal protein L12 | 0.0286809 |
| TMEM123 | transmembrane protein 123 | 0.0282457 |
| MKRN1 | makorin ring finger protein 1 | 0.0277773 |
| ADAR | adenosine deaminase, RNA-specific | 0.0277772 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0277334 |
| MXD1 | MAX dimerization protein 1 | 0.0277231 |
| MYO1B | myosin IB | 0.0275238 |
| ARRDC3 | arrestin domain containing 3 | 0.0271876 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.027082 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0268994 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0262033 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0260231 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0258969 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0257679 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0256753 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0255534 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0255322 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0255074 |
| FNBP1L | formin binding protein 1-like | 0.0253535 |
| MACC1 | metastasis associated in colon cancer 1 | 0.025285 |
| EPCAM | epithelial cell adhesion molecule | 0.0252513 |
| OPTN | optineurin | 0.0251698 |
| PDE8A | phosphodiesterase 8A | 0.0250746 |
| TPM3 | tropomyosin 3 | 0.0250256 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0248892 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0248111 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0247712 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0247572 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0244184 |
| RPS12 | ribosomal protein S12 | 0.0242484 |
| EHF | ets homologous factor | 0.0241393 |
| MYO5B | myosin VB | 0.0236768 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0234614 |
| DSG2 | desmoglein 2 | 0.0232954 |
| SET | SET nuclear proto-oncogene | 0.0232289 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0232119 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0230807 |
| APP | amyloid beta (A4) precursor protein | 0.023023 |
| ENO1 | enolase 1, (alpha) | 0.0229276 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0227191 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0225613 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.190102 |
| BCL2L1 | BCL2-like 1 | -0.150343 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.111593 |
| EGR1 | early growth response 1 | -0.098777 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0822576 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0760281 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0702839 |
| VCL | vinculin | -0.0682206 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0644193 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0626344 |
| TOP1 | topoisomerase (DNA) I | -0.0612125 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0610435 |
| SNX9 | sorting nexin 9 | -0.0605641 |
| TGFA | transforming growth factor, alpha | -0.0600013 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0547373 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0544651 |
| TMSB10 | thymosin beta 10 | -0.0533216 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0503697 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.049806 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0489215 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0470808 |
| CCND1 | cyclin D1 | -0.0420859 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.0402874 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.040124 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.039908 |
| FOSL1 | FOS-like antigen 1 | -0.0396859 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0382073 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.038054 |
| IER3 | immediate early response 3 | -0.0372093 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0368691 |
| FAM3C | family with sequence similarity 3, member C | -0.0365506 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0359233 |
| HDAC4 | histone deacetylase 4 | -0.0326054 |
| UBAP2 | ubiquitin associated protein 2 | -0.0325777 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0321308 |
| PKP4 | plakophilin 4 | -0.0321247 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0318438 |
| CDK13 | cyclin-dependent kinase 13 | -0.0317329 |
| AGO2 | argonaute RISC catalytic component 2 | -0.031677 |
| MYO1E | myosin IE | -0.0311625 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0307682 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0303843 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0297763 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0295004 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0294074 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0289253 |
| NF1 | neurofibromin 1 | -0.0286655 |
| ITGA6 | integrin, alpha 6 | -0.0285459 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0284412 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0277318 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.027457 |
| TNS4 | tensin 4 | -0.0267203 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0265668 |
| FTL | ferritin, light polypeptide | -0.0263737 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.025987 |
| EZR | ezrin | -0.0257325 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0256227 |
| GNAS | GNAS complex locus | -0.0249962 |
| ACTN1 | actinin, alpha 1 | -0.0249857 |
| MALT1 | MALT1 paracaspase | -0.0249389 |
| ETV5 | ets variant 5 | -0.0247926 |
| NUP98 | nucleoporin 98kDa | -0.0246269 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.023863 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0232833 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.023114 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.023003 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0229349 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0228647 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0227421 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0226261 |
| TRIB1 | tribbles pseudokinase 1 | -0.0226148 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0222339 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0220533 |
| TNPO3 | transportin 3 | -0.0219375 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0218357 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0216685 |
| RPS24 | ribosomal protein S24 | -0.0215564 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.021354 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0213313 |
| NEBL | nebulette | -0.0212223 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0210234 |
| OXSR1 | oxidative stress responsive 1 | -0.0209691 |
| INTS6 | integrator complex subunit 6 | -0.0207131 |
| TMEM41B | transmembrane protein 41B | -0.0206608 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0205812 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0204951 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0204401 |
| NHSL1 | NHS-like 1 | -0.0202166 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0201706 |
| DACH1 | dachshund family transcription factor 1 | -0.0201514 |
| CMTM7 | CKLF-like MARVEL transmembrane domain containing 7 | -0.0201258 |
| RUNX1 | runt-related transcription factor 1 | -0.0200582 |
| LAMA4 | laminin, alpha 4 | -0.0199866 |
| SETX | senataxin | -0.0198963 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0198737 |
| NFIA | nuclear factor I/A | -0.0197295 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0196955 |
| NLK | nemo-like kinase | -0.0195832 |
| SYK | spleen tyrosine kinase | -0.019417 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.019415 |
