| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib (DMSO_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD36 | CD36 molecule (thrombospondin receptor) | 0.350816 |
| RUNX2 | runt-related transcription factor 2 | 0.100614 |
| AXIN2 | axin 2 | 0.0768578 |
| OXR1 | oxidation resistance 1 | 0.0733824 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0729234 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0646841 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0607473 |
| ZNRF3 | zinc and ring finger 3 | 0.0569763 |
| RAD51B | RAD51 paralog B | 0.0546714 |
| GOLGA4 | golgin A4 | 0.0529563 |
| GNAT3 | guanine nucleotide binding protein, alpha transducing 3 | 0.052427 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0520229 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0503908 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0475059 |
| BBX | bobby sox homolog (Drosophila) | 0.045673 |
| DSPP | dentin sialophosphoprotein | 0.0426691 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0399351 |
| CANX | calnexin | 0.0392078 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.0379061 |
| OGA | O-GlcNAcase | 0.0376603 |
| PRELID2 | PRELI domain containing 2 | 0.0373649 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0370435 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0354362 |
| ANLN | anillin, actin binding protein | 0.0354141 |
| FAT1 | FAT atypical cadherin 1 | 0.035075 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0347686 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0343981 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0343515 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0339092 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0329864 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0322675 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0320669 |
| ZNF292 | zinc finger protein 292 | 0.0317274 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0314061 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0301589 |
| RPS2 | ribosomal protein S2 | 0.0297922 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0292011 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0291016 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0285683 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0282175 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0278857 |
| NCKAP1 | NCK-associated protein 1 | 0.0276132 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.027582 |
| NEK7 | NIMA-related kinase 7 | 0.0268161 |
| TNRC6B | trinucleotide repeat containing 6B | 0.026733 |
| RNF43 | ring finger protein 43 | 0.0267279 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0263628 |
| GPR15 | G protein-coupled receptor 15 | 0.025616 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0252698 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0250567 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0249783 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0246616 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0244893 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.024357 |
| COG5 | component of oligomeric golgi complex 5 | 0.0241872 |
| RBM33 | RNA binding motif protein 33 | 0.0239494 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0238938 |
| CEP152 | centrosomal protein 152kDa | 0.0235881 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0233546 |
| CDC73 | cell division cycle 73 | 0.0231755 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0229916 |
| TNS3 | tensin 3 | 0.0227661 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0227153 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0225277 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0221951 |
| ENO1 | enolase 1, (alpha) | 0.0221139 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0219977 |
| RLF | rearranged L-myc fusion | 0.0217801 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 0.021485 |
| PHKB | phosphorylase kinase, beta | 0.0214049 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0211713 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.021 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0206808 |
| CENPF | centromere protein F, 350/400kDa | 0.0204152 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0203497 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0203151 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0202552 |
| HELZ | helicase with zinc finger | 0.0202513 |
| SRP54 | signal recognition particle 54kDa | 0.0202232 |
| CEP350 | centrosomal protein 350kDa | 0.0202185 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0201033 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0199938 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0198542 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0198511 |
| RPL13A | ribosomal protein L13a | 0.0196335 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0195953 |
| CDK19 | cyclin-dependent kinase 19 | 0.0195844 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.01939 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0193329 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0193194 |
| TFG | TRK-fused gene | 0.019264 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0192586 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0192525 |
| KIZ | kizuna centrosomal protein | 0.0192436 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0191705 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0190615 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0190602 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0190055 |
| SBF2 | SET binding factor 2 | 0.0189393 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0188635 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.198787 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.164696 |
| AREG | amphiregulin | -0.151746 |
| HMGA2 | high mobility group AT-hook 2 | -0.144246 |
| EGR1 | early growth response 1 | -0.131692 |
| IER3 | immediate early response 3 | -0.13157 |
| TMSB10 | thymosin beta 10 | -0.117327 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.108932 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0897009 |
| FERMT1 | fermitin family member 1 | -0.0752473 |
| RCOR1 | REST corepressor 1 | -0.0709757 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.069907 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0673772 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0672755 |
| NDRG1 | N-myc downstream regulated 1 | -0.0669628 |
| PTMA | prothymosin, alpha | -0.0644045 |
| ANXA2 | annexin A2 | -0.0624105 |
| ACTG1 | actin gamma 1 | -0.0596803 |
| LAMC2 | laminin, gamma 2 | -0.0587227 |
| EGFR | epidermal growth factor receptor | -0.0582338 |
| EZR | ezrin | -0.0580457 |
| SNX9 | sorting nexin 9 | -0.0545045 |
| HMGA1 | high mobility group AT-hook 1 | -0.0536208 |
| S100A10 | S100 calcium binding protein A10 | -0.0527402 |
| ITGA6 | integrin, alpha 6 | -0.050414 |
| FOSL1 | FOS-like antigen 1 | -0.0487229 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.047773 |
| TOP1 | topoisomerase (DNA) I | -0.0450145 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0421168 |
| EMP1 | epithelial membrane protein 1 | -0.0420541 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0414486 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.040089 |
| FHL2 | four and a half LIM domains 2 | -0.0396841 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0392452 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0386326 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0375131 |
| LAMA4 | laminin, alpha 4 | -0.0373119 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0363993 |
| LAMB3 | laminin, beta 3 | -0.0353624 |
| LMO7 | LIM domain 7 | -0.0351908 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0351529 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.035063 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0347818 |
| S100A6 | S100 calcium binding protein A6 | -0.033546 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0334481 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0334296 |
| EREG | epiregulin | -0.0333105 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0332291 |
| FAM3C | family with sequence similarity 3, member C | -0.0327141 |
| KLK10 | kallikrein-related peptidase 10 | -0.0323052 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0312408 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0312171 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0310492 |
| BCL2L1 | BCL2-like 1 | -0.0309759 |
| VMP1 | vacuole membrane protein 1 | -0.0309445 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.030339 |
| TXNRD1 | thioredoxin reductase 1 | -0.0303224 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0297956 |
| TPM4 | tropomyosin 4 | -0.0295581 |
| CD9 | CD9 molecule | -0.0290793 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.0285022 |
| VCL | vinculin | -0.0282148 |
| RPS24 | ribosomal protein S24 | -0.0269554 |
| EHBP1 | EH domain binding protein 1 | -0.0269183 |
| MCL1 | myeloid cell leukemia 1 | -0.0264908 |
| S100A11 | S100 calcium binding protein A11 | -0.0263861 |
| SPATA13 | spermatogenesis associated 13 | -0.0263376 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.026126 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0256194 |
| KIAA0040 | KIAA0040 | -0.0244995 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0242265 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0241844 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0235746 |
| PERP | PERP, TP53 apoptosis effector | -0.0234296 |
| UBC | ubiquitin C | -0.0233593 |
| CUX1 | cut-like homeobox 1 | -0.0233524 |
| DUSP4 | dual specificity phosphatase 4 | -0.0232818 |
| GDF15 | growth differentiation factor 15 | -0.0231154 |
| MYO5B | myosin VB | -0.0229118 |
| LDHA | lactate dehydrogenase A | -0.0227447 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0225878 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.022534 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0225104 |
| CCND1 | cyclin D1 | -0.022165 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0218887 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0218339 |
| KRT18 | keratin 18, type I | -0.0217133 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.0211392 |
| ATL2 | atlastin GTPase 2 | -0.0210504 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0209706 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0208335 |
| CBX3 | chromobox homolog 3 | -0.0207517 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0205413 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0201393 |
| IER2 | immediate early response 2 | -0.0200138 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0198869 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.019764 |
| PALD1 | phosphatase domain containing, paladin 1 | -0.0196353 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0195185 |
| CDCP1 | CUB domain containing protein 1 | -0.0195113 |
