Trametinib (DMSO_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib (DMSO perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib (DMSO_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.505476
TNS3 tensin 3 0.128678
WWOX WW domain containing oxidoreductase 0.061305
AXIN2 axin 2 0.060625
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0598347
KIZ kizuna centrosomal protein 0.058939
CDH13 cadherin 13 0.0547708
DSPP dentin sialophosphoprotein 0.0528788
ZNRF3 zinc and ring finger 3 0.0503841
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0495002
BCAS3 breast carcinoma amplified sequence 3 0.047355
SOX5 SRY (sex determining region Y)-box 5 0.0437135
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0428583
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0400212
SERINC5 serine incorporator 5 0.0398929
PCBP2 poly(rC) binding protein 2 0.0385137
ZBTB20 zinc finger and BTB domain containing 20 0.0383196
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0382408
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0357828
PCLO piccolo presynaptic cytomatrix protein 0.0356186
PDE4D phosphodiesterase 4D, cAMP-specific 0.0350186
CNTNAP2 contactin associated protein-like 2 0.0342247
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0337831
SMOC2 SPARC related modular calcium binding 2 0.0336613
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0326948
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0322022
LPP LIM domain containing preferred translocation partner in lipoma 0.0321712
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0321686
MAN2A1 mannosidase, alpha, class 2A, member 1 0.032155
JMJD1C jumonji domain containing 1C 0.0315678
RAD51B RAD51 paralog B 0.0314236
SMYD3 SET and MYND domain containing 3 0.0305946
PCDH9 protocadherin 9 0.0305049
PTEN phosphatase and tensin homolog 0.0300767
MBNL2 muscleblind-like splicing regulator 2 0.030024
RNF213 ring finger protein 213 0.0285541
TBC1D5 TBC1 domain family, member 5 0.0282668
STK38L serine/threonine kinase 38 like 0.0279601
ZNF292 zinc finger protein 292 0.0279336
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0273165
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0272076
EXOC4 exocyst complex component 4 0.0264239
KDM6A lysine (K)-specific demethylase 6A 0.0263614
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0252296
TBC1D23 TBC1 domain family, member 23 0.0251141
NKD1 naked cuticle homolog 1 (Drosophila) 0.0249475
CLASP2 cytoplasmic linker associated protein 2 0.0246732
KREMEN1 kringle containing transmembrane protein 1 0.0241369
CMIP c-Maf inducing protein 0.023695
RBM39 RNA binding motif protein 39 0.0236806
BMP5 bone morphogenetic protein 5 0.0233029
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0224662
LRP6 low density lipoprotein receptor-related protein 6 0.0222016
ANK2 ankyrin 2, neuronal 0.0221169
RBM33 RNA binding motif protein 33 0.0220948
LRMDA leucine rich melanocyte differentiation associated 0.0220911
PRELID2 PRELI domain containing 2 0.0220746
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0220523
NCOA1 nuclear receptor coactivator 1 0.0219209
OGA O-GlcNAcase 0.0215445
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0215309
EPS8 epidermal growth factor receptor pathway substrate 8 0.0214824
TCF12 transcription factor 12 0.0214289
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0213506
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0211548
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 0.0210807
FRAS1 Fraser extracellular matrix complex subunit 1 0.0207544
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0207488
PLPP3 phospholipid phosphatase 3 0.0206274
CTNND1 catenin (cadherin-associated protein), delta 1 0.0205624
C2CD5 C2 calcium-dependent domain containing 5 0.0205165
KMT2C lysine (K)-specific methyltransferase 2C 0.0201891
DACH1 dachshund family transcription factor 1 0.0201155
CEP112 centrosomal protein 112kDa 0.0200526
EPB41 erythrocyte membrane protein band 4.1 0.0200238
RBM26 RNA binding motif protein 26 0.0196429
CBX5 chromobox homolog 5 0.0193387
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0192986
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0191235
METTL15 methyltransferase like 15 0.0190531
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0189205
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0188952
ARL15 ADP-ribosylation factor-like 15 0.0187678
FNIP1 folliculin interacting protein 1 0.0186174
LMCD1 LIM and cysteine-rich domains 1 0.0185272
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0183714
USP47 ubiquitin specific peptidase 47 0.0183652
ADAM10 ADAM metallopeptidase domain 10 0.0183083
AARS1 alanyl-tRNA synthetase 1 0.018258
TNRC6B trinucleotide repeat containing 6B 0.0182182
PHF21A PHD finger protein 21A 0.0182104
SBF2 SET binding factor 2 0.0181539
RABGAP1 RAB GTPase activating protein 1 0.0181533
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0179501
BICC1 BicC family RNA binding protein 1 0.0179486
CDK8 cyclin-dependent kinase 8 0.0179318
MYH9 myosin, heavy chain 9, non-muscle 0.0177287
MED13L mediator complex subunit 13-like 0.0177051
MBD5 methyl-CpG binding domain protein 5 0.0176356
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0174118

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.183445
TMSB10 thymosin beta 10 -0.120281
NAV2 neuron navigator 2 -0.10495
RPS6 ribosomal protein S6 -0.100699
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0981324
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0886298
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0885232
TPT1 tumor protein, translationally-controlled 1 -0.0874645
KRT18 keratin 18, type I -0.0840307
AKAP12 A kinase (PRKA) anchor protein 12 -0.0835408
PTMA prothymosin, alpha -0.0819806
RPL35A ribosomal protein L35a -0.0815365
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0675818
ACTG1 actin gamma 1 -0.0675354
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0644157
PDGFA platelet-derived growth factor alpha polypeptide -0.0618587
EGR1 early growth response 1 -0.0606521
KRT8 keratin 8, type II -0.0600611
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0593022
RPLP1 ribosomal protein, large, P1 -0.0591125
CCND1 cyclin D1 -0.0590997
RPS19 ribosomal protein S19 -0.0575904
ITGA6 integrin, alpha 6 -0.0569514
RPL23 ribosomal protein L23 -0.0563482
RPS3 ribosomal protein S3 -0.0561989
RPS8 ribosomal protein S8 -0.0532436
ENO1 enolase 1, (alpha) -0.0531589
RPL12 ribosomal protein L12 -0.0515769
MT2A metallothionein 2A -0.050625
VIM vimentin -0.0506027
RPL26 ribosomal protein L26 -0.0481068
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0469365
PGK1 phosphoglycerate kinase 1 -0.0469264
RPS24 ribosomal protein S24 -0.0469162
ACTN4 actinin, alpha 4 -0.0455535
EZR ezrin -0.0444032
EMP1 epithelial membrane protein 1 -0.0439491
S100A10 S100 calcium binding protein A10 -0.042746
PKM pyruvate kinase, muscle -0.0426884
EIF1 eukaryotic translation initiation factor 1 -0.0424517
ANXA2 annexin A2 -0.0421002
DUSP6 dual specificity phosphatase 6 -0.0415413
RPL19 ribosomal protein L19 -0.0412303
RPLP2 ribosomal protein, large, P2 -0.0404734
SLC38A1 solute carrier family 38, member 1 -0.039858
RPS12 ribosomal protein S12 -0.0384565
RACK1 receptor for activated C kinase 1 -0.0384297
ESYT2 extended synaptotagmin-like protein 2 -0.0383032
MAML2 mastermind-like 2 (Drosophila) -0.0381832
RPS27A ribosomal protein S27a -0.0379647
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.037626
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0375394
RPS25 ribosomal protein S25 -0.0371116
RPS13 ribosomal protein S13 -0.0367903
RPL37A ribosomal protein L37a -0.0366188
HMGA1 high mobility group AT-hook 1 -0.0363867
LOC102724023 ES1 protein homolog, mitochondrial -0.035814
INTS6 integrator complex subunit 6 -0.0352704
RPL36A ribosomal protein L36a -0.0352307
RPL31 ribosomal protein L31 -0.0350791
EFNB2 ephrin-B2 -0.0347819
RPL37 ribosomal protein L37 -0.034573
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0342673
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0340576
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0339211
FTL ferritin, light polypeptide -0.0338418
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0338231
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0337351
NDRG1 N-myc downstream regulated 1 -0.0337069
FRMD5 FERM domain containing 5 -0.0335466
LMO7 LIM domain 7 -0.0334329
S100A6 S100 calcium binding protein A6 -0.032969
SH3D19 SH3 domain containing 19 -0.0323121
PFN1 profilin 1 -0.0321316
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0320255
HDAC4 histone deacetylase 4 -0.0319855
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0318495
RPL7A ribosomal protein L7a -0.0316828
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0314771
RPL11 ribosomal protein L11 -0.0314674
RPS21 ribosomal protein S21 -0.0312311
RPS16 ribosomal protein S16 -0.0311541
ETV5 ets variant 5 -0.0310721
BACE2 beta-site APP-cleaving enzyme 2 -0.0308562
ANO1 anoctamin 1, calcium activated chloride channel -0.0306467
SVIL supervillin -0.0302778
RPL27A ribosomal protein L27a -0.0302259
RPL32 ribosomal protein L32 -0.0301528
ASPH aspartate beta-hydroxylase -0.0300802
ACTN1 actinin, alpha 1 -0.0298261
KLF5 Kruppel-like factor 5 (intestinal) -0.0297837
TMEM163 transmembrane protein 163 -0.0296462
RPL5 ribosomal protein L5 -0.0285805
FLNB filamin B, beta -0.028382
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0281757
RPS23 ribosomal protein S23 -0.028114
TPM4 tropomyosin 4 -0.0281125
NTSR1 neurotensin receptor 1 (high affinity) -0.0279465
RPS5 ribosomal protein S5 -0.0276534
RPL28 ribosomal protein L28 -0.0275562