| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib (DMSO perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trametinib (DMSO_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.281641 |
| COL1A1 | collagen, type I, alpha 1 | 0.198813 |
| COL1A2 | collagen, type I, alpha 2 | 0.194958 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.137238 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.131364 |
| FAM13A | family with sequence similarity 13, member A | 0.0877003 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0819259 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0802855 |
| COL3A1 | collagen, type III, alpha 1 | 0.07997 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.077173 |
| CALR | calreticulin | 0.0742864 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0720244 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0702036 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0671008 |
| DST | dystonin | 0.0631651 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.061605 |
| COL5A2 | collagen, type V, alpha 2 | 0.0605213 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0557303 |
| ANXA2 | annexin A2 | 0.0535078 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0515754 |
| ENO1 | enolase 1, (alpha) | 0.0515583 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0515575 |
| HLA-A | major histocompatibility complex, class I, A | 0.0469424 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0467258 |
| MYOF | myoferlin | 0.0465991 |
| FBN1 | fibrillin 1 | 0.046563 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0461941 |
| SQSTM1 | sequestosome 1 | 0.0458973 |
| ADM | adrenomedullin | 0.0455484 |
| SEPTIN9 | septin 9 | 0.0455196 |
| CALD1 | caldesmon 1 | 0.0449222 |
| NAV1 | neuron navigator 1 | 0.0435798 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.043536 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0432189 |
| OGA | O-GlcNAcase | 0.0432097 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.04221 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0413605 |
| GANAB | glucosidase, alpha; neutral AB | 0.0409162 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0397868 |
| CENPF | centromere protein F, 350/400kDa | 0.0393065 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0392084 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0389456 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0388407 |
| LOXL2 | lysyl oxidase-like 2 | 0.0386613 |
| DSCAM | Down syndrome cell adhesion molecule | 0.037996 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0370772 |
| GOLGA4 | golgin A4 | 0.0370699 |
| TPM3 | tropomyosin 3 | 0.0362704 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0354963 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0346945 |
| CDK19 | cyclin-dependent kinase 19 | 0.0341746 |
| SPAG9 | sperm associated antigen 9 | 0.0340755 |
| MED13L | mediator complex subunit 13-like | 0.0340489 |
| ARRDC3 | arrestin domain containing 3 | 0.0337218 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0335894 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0331987 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0331329 |
| THBS1 | thrombospondin 1 | 0.0330594 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0329423 |
| PGK1 | phosphoglycerate kinase 1 | 0.0328565 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0328548 |
| STC2 | stanniocalcin 2 | 0.0325884 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0325836 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0323179 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0315285 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0313547 |
| CANX | calnexin | 0.0312832 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0308528 |
| KLF6 | Kruppel-like factor 6 | 0.0307057 |
| RPL12 | ribosomal protein L12 | 0.0305272 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0304681 |
| LOX | lysyl oxidase | 0.0302043 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.0299767 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0297417 |
| RPS12 | ribosomal protein S12 | 0.0294406 |
| AHNAK | AHNAK nucleoprotein | 0.029318 |
| FRMD6 | FERM domain containing 6 | 0.029114 |
| NGLY1 | N-glycanase 1 | 0.0285027 |
| SETD5 | SET domain containing 5 | 0.0285017 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0280317 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0279802 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0279145 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0277675 |
| HMGB2 | high mobility group box 2 | 0.0276827 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0275768 |
| RPS3 | ribosomal protein S3 | 0.0275704 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.027473 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0274353 |
| EXOC4 | exocyst complex component 4 | 0.0273131 |
| HLA-E | major histocompatibility complex, class I, E | 0.0272566 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0265857 |
| RPS8 | ribosomal protein S8 | 0.0262672 |
| SMAD3 | SMAD family member 3 | 0.0262272 |
| GOLGA2 | golgin A2 | 0.0261236 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0260447 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0258522 |
| PRR16 | proline rich 16 | 0.0256515 |
| TPM2 | tropomyosin 2 (beta) | 0.0254336 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0252696 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0250974 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | -0.326321 |
| INHBA | inhibin, beta A | -0.159355 |
| NDRG1 | N-myc downstream regulated 1 | -0.115124 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0921606 |
| MYO10 | myosin X | -0.0815006 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0769868 |
| CD44 | CD44 molecule (Indian blood group) | -0.0673957 |
| TMSB10 | thymosin beta 10 | -0.0667851 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0667429 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0598686 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.056531 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0520306 |
| EGR1 | early growth response 1 | -0.0507991 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0500891 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0483626 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0471895 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0471192 |
| MMP1 | matrix metallopeptidase 1 | -0.0449007 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0432012 |
| HMGA2 | high mobility group AT-hook 2 | -0.0403955 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0397724 |
| CDH13 | cadherin 13 | -0.037578 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0372155 |
| FN1 | fibronectin 1 | -0.0364162 |
| YBX3 | Y box binding protein 3 | -0.0361157 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0358501 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0356577 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0354018 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0353678 |
| MT2A | metallothionein 2A | -0.0349378 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0340299 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0338414 |
| PKM | pyruvate kinase, muscle | -0.0331505 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0326756 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0324714 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0324487 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0314153 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0300321 |
| IER3 | immediate early response 3 | -0.0299961 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0297605 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0297237 |
| RPL32 | ribosomal protein L32 | -0.0295666 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0295013 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0293335 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0292001 |
| DNER | delta/notch-like EGF repeat containing | -0.0290264 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0289312 |
| GPATCH2L | G patch domain containing 2-like | -0.0283812 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0283774 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0283012 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0280377 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0278783 |
| MCL1 | myeloid cell leukemia 1 | -0.0277805 |
| FRMD4A | FERM domain containing 4A | -0.027495 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0270613 |
| MYADM | myeloid-associated differentiation marker | -0.0270489 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0268678 |
| TOP1 | topoisomerase (DNA) I | -0.0267575 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0266211 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0265774 |
| TMEM165 | transmembrane protein 165 | -0.0263446 |
| NOTCH2 | notch 2 | -0.0261893 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0257349 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0255647 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0254626 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0251873 |
| CCND1 | cyclin D1 | -0.0251089 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0245234 |
| SIK3 | SIK family kinase 3 | -0.0244247 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.023998 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0237217 |
| HMGA1 | high mobility group AT-hook 1 | -0.0235758 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.023563 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0226129 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0222673 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.0220592 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0220456 |
| AHI1 | Abelson helper integration site 1 | -0.0218781 |
| NUMB | numb homolog (Drosophila) | -0.0217784 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0214894 |
| FOXP1 | forkhead box P1 | -0.0212961 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | -0.0212064 |
| HAS2 | hyaluronan synthase 2 | -0.020972 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0209465 |
| COPA | coatomer protein complex, subunit alpha | -0.0209017 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0208756 |
| KIAA1549L | KIAA1549-like | -0.0208622 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0206452 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0204763 |
| ATP13A3 | ATPase type 13A3 | -0.0202722 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0202062 |
| POTEF | POTE ankyrin domain family, member F | -0.0200898 |
| RNF145 | ring finger protein 145 | -0.0200433 |
| DUSP6 | dual specificity phosphatase 6 | -0.0199574 |
| AFF3 | AF4/FMR2 family, member 3 | -0.019865 |
| IL6 | interleukin 6 | -0.0197512 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0197468 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0196664 |
| AGO3 | argonaute RISC catalytic component 3 | -0.019589 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0195521 |
