Trametinib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.203174
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.138354
FBN1 fibrillin 1 0.118657
AHNAK AHNAK nucleoprotein 0.0963609
DST dystonin 0.0833737
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0762281
COL3A1 collagen, type III, alpha 1 0.0694978
FLNA filamin A, alpha 0.0690112
AHNAK2 AHNAK nucleoprotein 2 0.0656603
SOD2 superoxide dismutase 2, mitochondrial 0.0637343
NFE2L1 nuclear factor, erythroid 2-like 1 0.0587216
MBNL2 muscleblind-like splicing regulator 2 0.0575533
MYH9 myosin, heavy chain 9, non-muscle 0.0560935
LMNA lamin A/C 0.0551424
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0529505
LOXL2 lysyl oxidase-like 2 0.0513257
COL5A1 collagen, type V, alpha 1 0.0507721
GSE1 Gse1 coiled-coil protein 0.0498239
CALR calreticulin 0.0487081
TPM4 tropomyosin 4 0.0481524
COL1A2 collagen, type I, alpha 2 0.0470268
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.044189
DCLK2 doublecortin-like kinase 2 0.0433381
ACTG1 actin gamma 1 0.043005
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0429203
TENM3 teneurin transmembrane protein 3 0.0417599
TRIO trio Rho guanine nucleotide exchange factor 0.0405577
RNF213 ring finger protein 213 0.0402733
FBXL7 F-box and leucine-rich repeat protein 7 0.0395837
ENAH enabled homolog (Drosophila) 0.0394457
HSPB1 heat shock 27kDa protein 1 0.0394304
FSTL1 follistatin-like 1 0.0391099
SORBS2 sorbin and SH3 domain containing 2 0.0390356
COL5A2 collagen, type V, alpha 2 0.037939
EEF2 eukaryotic translation elongation factor 2 0.0378967
VIM vimentin 0.0369921
GASK1B golgi associated kinase 1B 0.0362759
DPYSL3 dihydropyrimidinase-like 3 0.0360732
TNS3 tensin 3 0.0354491
CUX1 cut-like homeobox 1 0.0352509
MYOF myoferlin 0.0350583
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0347705
HDAC9 histone deacetylase 9 0.0341824
MB21D2 Mab-21 domain containing 2 0.0341646
TXNIP thioredoxin interacting protein 0.0339914
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0339721
SFTPA2 surfactant protein A2 0.0335342
AUTS2 autism susceptibility candidate 2 0.0322761
RHOA ras homolog family member A 0.0319993
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0299896
TRABD2B TraB domain containing 2B 0.0295073
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0293413
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0293083
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0278449
ANK2 ankyrin 2, neuronal 0.0276184
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0275519
DSG2 desmoglein 2 0.0269297
HLA-B major histocompatibility complex, class I, B 0.0268283
SMYD3 SET and MYND domain containing 3 0.0266032
LYST lysosomal trafficking regulator 0.0262208
TUFT1 tuftelin 1 0.0256597
CTSB cathepsin B 0.025646
CAVIN1 caveolae associated protein 1 0.025524
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.0247587
ZMIZ1 zinc finger, MIZ-type containing 1 0.0244977
TGFB2 transforming growth factor, beta 2 0.0243741
L1CAM L1 cell adhesion molecule 0.0239904
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0239198
COL1A1 collagen, type I, alpha 1 0.0234845
LIMCH1 LIM and calponin homology domains 1 0.0225104
PLXDC2 plexin domain containing 2 0.0224368
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0219134
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0218982
CLIP1 CAP-GLY domain containing linker protein 1 0.021505
MKX mohawk homeobox 0.0209379
ANGPTL7 angiopoietin-like 7 0.0207674
LMO7 LIM domain 7 0.0206074
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.0205815
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0201532
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0201465
PRRC2C proline-rich coiled-coil 2C 0.0199297
MINK1 misshapen-like kinase 1 0.0192355
CCDC85A coiled-coil domain containing 85A 0.0190993
MRTFA myocardin related transcription factor A 0.0189664
DSPP dentin sialophosphoprotein 0.0188424
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0187963
TPM1 tropomyosin 1 (alpha) 0.0184454
TNIP1 TNFAIP3 interacting protein 1 0.0183619
KRT18 keratin 18, type I 0.0183049
PRELID2 PRELI domain containing 2 0.0182537
ANKRD36 ankyrin repeat domain 36 0.0181733
APP amyloid beta (A4) precursor protein 0.0181408
KRT81 keratin 81, type II 0.0181393
ZMYND8 zinc finger, MYND-type containing 8 0.017934
TUBB tubulin, beta class I 0.0178517
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0178503
ANKRD30B ankyrin repeat domain 30B 0.017699
HEG1 heart development protein with EGF-like domains 1 0.0176985
SLFN5 schlafen family member 5 0.0176217
PLIN3 perilipin 3 0.0174614

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.22994
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.182168
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.169583
LOX lysyl oxidase -0.154344
MT2A metallothionein 2A -0.122577
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11457
PODXL podocalyxin-like -0.101422
CDH13 cadherin 13 -0.0881799
CD44 CD44 molecule (Indian blood group) -0.0879601
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0782061
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0765941
STC1 stanniocalcin 1 -0.0754677
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0751984
NDRG1 N-myc downstream regulated 1 -0.0746848
FNDC3B fibronectin type III domain containing 3B -0.0728619
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0700461
DLG1 discs, large homolog 1 (Drosophila) -0.0668264
IGFBP3 insulin-like growth factor binding protein 3 -0.0650904
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0647907
ELL2 elongation factor, RNA polymerase II, 2 -0.0624218
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0619381
CCND1 cyclin D1 -0.0599449
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0553859
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0548294
TMSB10 thymosin beta 10 -0.052237
ZEB1 zinc finger E-box binding homeobox 1 -0.0511822
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0487007
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0486363
MYADM myeloid-associated differentiation marker -0.0477395
BHLHE40 basic helix-loop-helix family, member e40 -0.0462488
RTN4 reticulon 4 -0.0452253
PLAT plasminogen activator, tissue -0.0451478
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0449624
WWTR1 WW domain containing transcription regulator 1 -0.0447394
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0445481
EFNA5 ephrin-A5 -0.044357
PBX3 pre-B-cell leukemia homeobox 3 -0.0442672
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0437014
EPAS1 endothelial PAS domain protein 1 -0.0436066
FRMD4A FERM domain containing 4A -0.0431179
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0429718
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0406465
FTH1 ferritin, heavy polypeptide 1 -0.0404729
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0389137
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0388281
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0384618
PSD3 pleckstrin and Sec7 domain containing 3 -0.0380712
RAB7A RAB7A, member RAS oncogene family -0.0373247
ASPH aspartate beta-hydroxylase -0.0368704
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0364572
UBC ubiquitin C -0.0356381
FLNB filamin B, beta -0.0330337
FOSL1 FOS-like antigen 1 -0.0326141
COPA coatomer protein complex, subunit alpha -0.0325961
FBXO11 F-box protein 11 -0.0318539
ANXA2 annexin A2 -0.0317735
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0311801
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0305598
SOX9 SRY (sex determining region Y)-box 9 -0.0297881
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0296104
MRPS6 mitochondrial ribosomal protein S6 -0.0291324
GLIS3 GLIS family zinc finger 3 -0.0282984
IARS1 isoleucyl-tRNA synthetase 1 -0.0276543
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0276252
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.027372
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0269124
FNDC3A fibronectin type III domain containing 3A -0.0266814
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0266449
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0264249
ZNF207 zinc finger protein 207 -0.0262412
DOCK5 dedicator of cytokinesis 5 -0.0259364
NT5E 5'-nucleotidase, ecto (CD73) -0.02562
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0255387
PXDN peroxidasin -0.025215
MSI2 musashi RNA-binding protein 2 -0.0251111
AFF3 AF4/FMR2 family, member 3 -0.0251091
FNIP1 folliculin interacting protein 1 -0.0249845
SP3 Sp3 transcription factor -0.0249821
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0248412
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0245304
SEC24D SEC24 family member D -0.0243631
TAGLN2 transgelin 2 -0.0243371
PKM pyruvate kinase, muscle -0.0242608
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0241547
TRA2A transformer 2 alpha homolog (Drosophila) -0.0240008
RIGI RNA sensor RIG-I -0.0233675
HILPDA hypoxia inducible lipid droplet-associated -0.0233318
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0231604
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0230244
CD109 CD109 molecule -0.0228815
BACE2 beta-site APP-cleaving enzyme 2 -0.0224488
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0224084
LMAN1 lectin, mannose-binding, 1 -0.022403
ADAM17 ADAM metallopeptidase domain 17 -0.0222175
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0222001
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0221844
ARL4C ADP-ribosylation factor-like 4C -0.0220497
TM4SF1 transmembrane 4 L six family member 1 -0.0219274
SUCO SUN domain containing ossification factor -0.0218665
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0217449