| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TENM3 | teneurin transmembrane protein 3 | 0.103249 |
| NLGN1 | neuroligin 1 | 0.0860049 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0825006 |
| AREG | amphiregulin | 0.0813318 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0701345 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0685405 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0665479 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0634196 |
| PCBP2 | poly(rC) binding protein 2 | 0.0562785 |
| CPOX | coproporphyrinogen oxidase | 0.0553896 |
| MED13L | mediator complex subunit 13-like | 0.0445831 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0441672 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0439076 |
| CALR | calreticulin | 0.0408364 |
| EPHA6 | EPH receptor A6 | 0.0397436 |
| RPL3 | ribosomal protein L3 | 0.0396996 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0396966 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0385151 |
| PDGFC | platelet derived growth factor C | 0.0369889 |
| PTMS | parathymosin | 0.0361961 |
| TMEM41B | transmembrane protein 41B | 0.0361083 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0355745 |
| EPHA5 | EPH receptor A5 | 0.0352229 |
| OXR1 | oxidation resistance 1 | 0.0344589 |
| MGAT4C | MGAT4 family, member C | 0.0340437 |
| CDK6 | cyclin-dependent kinase 6 | 0.0339224 |
| NRXN3 | neurexin 3 | 0.0329061 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0326285 |
| TMSB10 | thymosin beta 10 | 0.0318288 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.030947 |
| MPG | N-methylpurine-DNA glycosylase | 0.030254 |
| POTEF | POTE ankyrin domain family, member F | 0.0300366 |
| AXIN2 | axin 2 | 0.0295205 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0284728 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0281514 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.02758 |
| VMP1 | vacuole membrane protein 1 | 0.0273492 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0270205 |
| FLNA | filamin A, alpha | 0.0269048 |
| TXNRD1 | thioredoxin reductase 1 | 0.0268305 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0261202 |
| RAB6A | RAB6A, member RAS oncogene family | 0.02595 |
| RTN4 | reticulon 4 | 0.0256608 |
| PRKCI | protein kinase C, iota | 0.0255217 |
| SYT1 | synaptotagmin I | 0.025083 |
| RPS12 | ribosomal protein S12 | 0.0243777 |
| TGM2 | transglutaminase 2 | 0.0240958 |
| PRR16 | proline rich 16 | 0.0236557 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0233389 |
| CMIP | c-Maf inducing protein | 0.023316 |
| XPO1 | exportin 1 | 0.0229328 |
| FSTL5 | follistatin-like 5 | 0.0228819 |
| KLHL24 | kelch-like family member 24 | 0.0221401 |
| ARRDC3 | arrestin domain containing 3 | 0.0219158 |
| TPI1 | triosephosphate isomerase 1 | 0.0217629 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0213112 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0211232 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0204384 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0202758 |
| YBX1 | Y box binding protein 1 | 0.0198626 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0196991 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0191406 |
| HDAC9 | histone deacetylase 9 | 0.0190702 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0190142 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0190002 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.018721 |
| CLDND1 | claudin domain containing 1 | 0.0185715 |
| CCNL1 | cyclin L1 | 0.0185535 |
| PCM1 | pericentriolar material 1 | 0.0182393 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0182149 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.018043 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0180286 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0179653 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0174536 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0173895 |
| CEP70 | centrosomal protein 70kDa | 0.0172244 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0171982 |
| SSRP1 | structure specific recognition protein 1 | 0.0169904 |
| ATP9A | ATPase, class II, type 9A | 0.0169739 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0169308 |
| NCOA1 | nuclear receptor coactivator 1 | 0.0167309 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0166837 |
| PLEC | plectin | 0.0163962 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0163532 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0163308 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0160747 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0160571 |
| GASK1B | golgi associated kinase 1B | 0.0158424 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0158096 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0155889 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0155218 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0153373 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0151784 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0151397 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0151125 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0151057 |
| CASC3 | cancer susceptibility candidate 3 | 0.0149409 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0147223 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.0146232 |
| PFN1 | profilin 1 | 0.0145724 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGA2 | high mobility group AT-hook 2 | -0.125757 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0965185 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0886955 |
| PCDH7 | protocadherin 7 | -0.0876562 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.085125 |
| EHBP1 | EH domain binding protein 1 | -0.0789884 |
| ASPH | aspartate beta-hydroxylase | -0.078031 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.060176 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0594961 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0561617 |
| BCHE | butyrylcholinesterase | -0.0558544 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0553546 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0539564 |
| VIM | vimentin | -0.0528538 |
| NHSL1 | NHS-like 1 | -0.052471 |
| MTAP | methylthioadenosine phosphorylase | -0.0522117 |
| ZNF804A | zinc finger protein 804A | -0.0470048 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0439223 |
| INTS6 | integrator complex subunit 6 | -0.0432784 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0430155 |
| CANX | calnexin | -0.0426994 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0426749 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0417284 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0379693 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0368163 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0350756 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0325221 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0311638 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0292922 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0292823 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0291673 |
| ADIPOR2 | adiponectin receptor 2 | -0.0280784 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0279905 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0279223 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0278906 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0278701 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0275924 |
| H1-0 | H1.0 linker histone | -0.027474 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0273979 |
| NAV3 | neuron navigator 3 | -0.0269426 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0262141 |
| RPS27A | ribosomal protein S27a | -0.0257203 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0256466 |
| CLDN1 | claudin 1 | -0.0256372 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.025509 |
| PTMA | prothymosin, alpha | -0.0253386 |
| TMEM123 | transmembrane protein 123 | -0.0250577 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0250171 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0242092 |
| NF1 | neurofibromin 1 | -0.0241982 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0237958 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0234101 |
| MMP12 | matrix metallopeptidase 12 | -0.0231938 |
| USP53 | ubiquitin specific peptidase 53 | -0.0231905 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0231793 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0229103 |
| LRRC23 | leucine rich repeat containing 23 | -0.0229033 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0228233 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.022715 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0223545 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0222095 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0218752 |
| EGR1 | early growth response 1 | -0.0218216 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0216164 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0216065 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0214163 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0213697 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0212447 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0207462 |
| ABI2 | abl-interactor 2 | -0.0207149 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0206722 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0205936 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0202813 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0201686 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0200744 |
| RAI14 | retinoic acid induced 14 | -0.0197395 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0197185 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0196406 |
| TPM4 | tropomyosin 4 | -0.0195807 |
| CUX1 | cut-like homeobox 1 | -0.0192371 |
| GPHN | gephyrin | -0.018925 |
| ZNF407 | zinc finger protein 407 | -0.0188406 |
| CCDC47 | coiled-coil domain containing 47 | -0.0188133 |
| WDR45B | WD repeat domain 45B | -0.0188118 |
| RASAL2 | RAS protein activator like 2 | -0.0188047 |
| PGK1 | phosphoglycerate kinase 1 | -0.0186803 |
| AHNAK | AHNAK nucleoprotein | -0.018584 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0185808 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0185057 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0184833 |
| INTS4 | integrator complex subunit 4 | -0.0183681 |
| CCND1 | cyclin D1 | -0.0181984 |
| RPS24 | ribosomal protein S24 | -0.0178002 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0177596 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0176633 |
| HMGA1 | high mobility group AT-hook 1 | -0.0175544 |
| SNX14 | sorting nexin 14 | -0.0175525 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0175242 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0174742 |
| AEBP2 | AE binding protein 2 | -0.0173874 |
