| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SYT1 | synaptotagmin I | 0.0922385 |
| LPIN1 | lipin 1 | 0.083366 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0734888 |
| DST | dystonin | 0.0709502 |
| AHNAK | AHNAK nucleoprotein | 0.0631271 |
| RALYL | RALY RNA binding protein-like | 0.0623768 |
| MAP1B | microtubule-associated protein 1B | 0.0518055 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0516413 |
| ACTG1 | actin gamma 1 | 0.050033 |
| RNF213 | ring finger protein 213 | 0.047516 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0421888 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0420091 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.040764 |
| PALLD | palladin, cytoskeletal associated protein | 0.0379945 |
| RPL3 | ribosomal protein L3 | 0.03799 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0376818 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0376389 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0367434 |
| TRIM37 | tripartite motif containing 37 | 0.0359934 |
| PLPP1 | phospholipid phosphatase 1 | 0.0354783 |
| AUTS2 | autism susceptibility candidate 2 | 0.0348788 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0345588 |
| HMBOX1 | homeobox containing 1 | 0.0344417 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0343204 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0341708 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0338735 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0337631 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0324159 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0322727 |
| AOPEP | aminopeptidase O (putative) | 0.0320746 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0316936 |
| ANXA2 | annexin A2 | 0.0307058 |
| COL1A1 | collagen, type I, alpha 1 | 0.0306027 |
| RPL4 | ribosomal protein L4 | 0.0295926 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0295457 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0292416 |
| FMN1 | formin 1 | 0.0291704 |
| PCM1 | pericentriolar material 1 | 0.0282359 |
| FOXO3 | forkhead box O3 | 0.028002 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0272699 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0268205 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0263901 |
| ZNF804A | zinc finger protein 804A | 0.026379 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0262551 |
| MRTFA | myocardin related transcription factor A | 0.0261862 |
| EPHA3 | EPH receptor A3 | 0.0261625 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0261378 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0260922 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.025915 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0258168 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0257045 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0254346 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0251509 |
| MEMO1 | mediator of cell motility 1 | 0.0251004 |
| SETD2 | SET domain containing 2 | 0.0249344 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0248953 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.0248099 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0247129 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0244819 |
| TNS3 | tensin 3 | 0.0243089 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0240242 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0239337 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0239271 |
| DGKH | diacylglycerol kinase, eta | 0.0238501 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0234297 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0233448 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.023012 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.02269 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0226889 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0225922 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0223785 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.022199 |
| FAM219A | family with sequence similarity 219, member A | 0.0220985 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0219621 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0219501 |
| TNPO1 | transportin 1 | 0.0219245 |
| PANK3 | pantothenate kinase 3 | 0.0218999 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0217679 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0216207 |
| PCDH9 | protocadherin 9 | 0.0215246 |
| NCKAP1 | NCK-associated protein 1 | 0.0213543 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0211676 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.021112 |
| LMNA | lamin A/C | 0.0209776 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0206134 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0205546 |
| VWA8 | von Willebrand factor A domain containing 8 | 0.0204555 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0203581 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 0.0202389 |
| FBXO32 | F-box protein 32 | 0.0199571 |
| SLMAP | sarcolemma associated protein | 0.0197729 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0197416 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0196643 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.019454 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0192766 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.0192367 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0189346 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0186031 |
| ZNF148 | zinc finger protein 148 | 0.0185974 |
| KDM5A | lysine (K)-specific demethylase 5A | 0.018497 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.208551 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.173775 |
| EXT1 | exostosin glycosyltransferase 1 | -0.149667 |
| LSAMP | limbic system-associated membrane protein | -0.122636 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.108605 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0991698 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.096156 |
| PLAT | plasminogen activator, tissue | -0.094415 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0748576 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0741063 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0700518 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0688898 |
| STC1 | stanniocalcin 1 | -0.0686023 |
| VCL | vinculin | -0.0684842 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0672791 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0630211 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0626426 |
| FRMD4A | FERM domain containing 4A | -0.0620559 |
| DPH6 | diphthamine biosynthesis 6 | -0.0620361 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0612625 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0605799 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0586825 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0556864 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0544708 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0539475 |
| MCL1 | myeloid cell leukemia 1 | -0.053644 |
| CENPF | centromere protein F, 350/400kDa | -0.053036 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0527116 |
| GOLGA4 | golgin A4 | -0.0521604 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0518743 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0504774 |
| GPC5 | glypican 5 | -0.0502972 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0496197 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0476074 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0464442 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0462856 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0451622 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0445374 |
| VIM | vimentin | -0.0444215 |
| MAPK10 | mitogen-activated protein kinase 10 | -0.0440331 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0439961 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0432155 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0430829 |
| NDRG1 | N-myc downstream regulated 1 | -0.0422553 |
| FAM13A | family with sequence similarity 13, member A | -0.0410286 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0401904 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0398258 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0393547 |
| TOP1 | topoisomerase (DNA) I | -0.0384628 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0384281 |
| NREP | neuronal regeneration related protein | -0.0383746 |
| FN1 | fibronectin 1 | -0.0379723 |
| EGR1 | early growth response 1 | -0.0378736 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | -0.0378364 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0371977 |
| MORF4L2 | mortality factor 4 like 2 | -0.0367058 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0365358 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0363153 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.035668 |
| PRKCA | protein kinase C, alpha | -0.0354973 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0350849 |
| HMGA2 | high mobility group AT-hook 2 | -0.0349661 |
| BPTF | bromodomain PHD finger transcription factor | -0.0346013 |
| GDF15 | growth differentiation factor 15 | -0.0344681 |
| IER3 | immediate early response 3 | -0.0342102 |
| MEF2A | myocyte enhancer factor 2A | -0.0341415 |
| LMAN1 | lectin, mannose-binding, 1 | -0.034095 |
| ASPH | aspartate beta-hydroxylase | -0.0334134 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0331083 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0329955 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0326509 |
| CANX | calnexin | -0.0326344 |
| KLHL13 | kelch-like family member 13 | -0.0325774 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0323597 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0320245 |
| MSI2 | musashi RNA-binding protein 2 | -0.0316947 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0315455 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0314498 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0312929 |
| PCBP3 | poly(rC) binding protein 3 | -0.0308053 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0305819 |
| HM13 | histocompatibility (minor) 13 | -0.0304028 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0303852 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0300507 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0299154 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0298974 |
| KIAA1217 | KIAA1217 | -0.0296128 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0294682 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0292985 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0291498 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0291436 |
| TPM1 | tropomyosin 1 (alpha) | -0.0289574 |
| CDH13 | cadherin 13 | -0.0289063 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0287823 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0283644 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0281137 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0280582 |
| PHF3 | PHD finger protein 3 | -0.0274824 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0274476 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0274427 |
