| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trametinib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trametinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0895 |
| NDRG1 | N-myc downstream regulated 1 | 0.0830339 |
| MUC13 | mucin 13, cell surface associated | 0.0515849 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0465368 |
| RNF213 | ring finger protein 213 | 0.0460392 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0394731 |
| OCLN | occludin | 0.0326652 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.032434 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0312915 |
| PDZD8 | PDZ domain containing 8 | 0.0306008 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0302505 |
| DST | dystonin | 0.0292204 |
| ATP10B | ATPase, class V, type 10B | 0.0291534 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0231094 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0227841 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0224247 |
| KIF16B | kinesin family member 16B | 0.0217163 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0215512 |
| MLPH | melanophilin | 0.0213626 |
| TRIM2 | tripartite motif containing 2 | 0.0204633 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0199767 |
| HKDC1 | hexokinase domain containing 1 | 0.0199289 |
| NEBL | nebulette | 0.0199089 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0196146 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0192725 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0185427 |
| GOLGA2 | golgin A2 | 0.0172554 |
| SERINC5 | serine incorporator 5 | 0.0169019 |
| FHL2 | four and a half LIM domains 2 | 0.016791 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0167401 |
| TUFT1 | tuftelin 1 | 0.0166781 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0163225 |
| FRK | fyn-related Src family tyrosine kinase | 0.0162958 |
| PHF3 | PHD finger protein 3 | 0.0162203 |
| GALNT15 | polypeptide N-acetylgalactosaminyltransferase 15 | 0.0159131 |
| CDHR2 | cadherin-related family member 2 | 0.015772 |
| MUC20 | mucin 20, cell surface associated | 0.0156937 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.015584 |
| MYO1E | myosin IE | 0.0154739 |
| APOL2 | apolipoprotein L, 2 | 0.0153639 |
| TMC5 | transmembrane channel-like 5 | 0.0149443 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.0146155 |
| USP12 | ubiquitin specific peptidase 12 | 0.0145755 |
| CGN | cingulin | 0.0144737 |
| MYO5B | myosin VB | 0.0141652 |
| FNBP4 | formin binding protein 4 | 0.0140588 |
| CLOCK | clock circadian regulator | 0.0138732 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0138505 |
| RPAIN | RPA interacting protein | 0.0138481 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0138023 |
| DUSP10 | dual specificity phosphatase 10 | 0.0137141 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0136597 |
| RPL3 | ribosomal protein L3 | 0.013469 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0134044 |
| VEGFA | vascular endothelial growth factor A | 0.0133487 |
| TSPYL2 | TSPY-like 2 | 0.0132937 |
| UBL3 | ubiquitin-like 3 | 0.0132698 |
| HDLBP | high density lipoprotein binding protein | 0.0132608 |
| TMEM51 | transmembrane protein 51 | 0.0130755 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0128351 |
| FNIP2 | folliculin interacting protein 2 | 0.012715 |
| TSPAN3 | tetraspanin 3 | 0.0126831 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0125709 |
| RBM47 | RNA binding motif protein 47 | 0.0123767 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0122645 |
| DAND5 | DAN domain family member 5, BMP antagonist | 0.0121953 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0121656 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0121331 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.0118584 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0118042 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.01174 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.0116112 |
| ATF3 | activating transcription factor 3 | 0.0115375 |
| GOLGA3 | golgin A3 | 0.0114105 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0113051 |
| BNIP5 | BCL2 interacting protein 5 | 0.0112658 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.0112258 |
| PNPLA7 | patatin-like phospholipase domain containing 7 | 0.0111612 |
| XPOT | exportin, tRNA | 0.0109277 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0108476 |
| ARFGAP1 | ADP-ribosylation factor GTPase activating protein 1 | 0.0107649 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0106714 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0106688 |
| RASSF6 | Ras association (RalGDS/AF-6) domain family member 6 | 0.0105824 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0105507 |
| TRIM31 | tripartite motif containing 31 | 0.0105159 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0104063 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0103703 |
| EXPH5 | exophilin 5 | 0.0103546 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0102734 |
| CFB | complement factor B | 0.0100792 |
| KAZN | kazrin, periplakin interacting protein | 0.0100611 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0100479 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | 0.00999561 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.00994167 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.00991161 |
| RBM33 | RNA binding motif protein 33 | 0.00982738 |
| PALLD | palladin, cytoskeletal associated protein | 0.00980902 |
| PPP1R3B | protein phosphatase 1, regulatory subunit 3B | 0.00974089 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.00970129 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.139735 |
| EGR1 | early growth response 1 | -0.125772 |
| ANXA2 | annexin A2 | -0.122563 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.11184 |
| ITGA6 | integrin, alpha 6 | -0.0987334 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.090769 |
| PRKCA | protein kinase C, alpha | -0.0893489 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0881007 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0878156 |
| B2M | beta-2-microglobulin | -0.0871177 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0834536 |
| RUNX1 | runt-related transcription factor 1 | -0.0834045 |
| LCN2 | lipocalin 2 | -0.0793518 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0788002 |
| AREG | amphiregulin | -0.0759776 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0759274 |
| EFNB2 | ephrin-B2 | -0.0752906 |
| PKM | pyruvate kinase, muscle | -0.0709122 |
| ASPH | aspartate beta-hydroxylase | -0.0706778 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.069238 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0692002 |
| PTMA | prothymosin, alpha | -0.0684016 |
| PERP | PERP, TP53 apoptosis effector | -0.06834 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0656446 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0620013 |
| INTS6 | integrator complex subunit 6 | -0.0598817 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0596043 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0539796 |
| MSI2 | musashi RNA-binding protein 2 | -0.0529723 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0523575 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0518279 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.051077 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0502864 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0499053 |
| LYZ | lysozyme | -0.048639 |
| MEIS2 | Meis homeobox 2 | -0.0483845 |
| EZR | ezrin | -0.0481506 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0478353 |
| EPHB2 | EPH receptor B2 | -0.0474274 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0461321 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0455081 |
| ABHD2 | abhydrolase domain containing 2 | -0.0453634 |
| MAP7 | microtubule-associated protein 7 | -0.0446174 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.043399 |
| LAMA4 | laminin, alpha 4 | -0.0431989 |
| TXNIP | thioredoxin interacting protein | -0.0422143 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0419022 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0418573 |
| ATP11A | ATPase, class VI, type 11A | -0.0416511 |
| HLA-B | major histocompatibility complex, class I, B | -0.0415708 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0405964 |
| NF1 | neurofibromin 1 | -0.040455 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0402272 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0401261 |
| NCKAP5 | NCK-associated protein 5 | -0.0398778 |
| SDC4 | syndecan 4 | -0.0398647 |
| ABLIM1 | actin binding LIM protein 1 | -0.0394589 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0385843 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0372223 |
| TMSB10 | thymosin beta 10 | -0.0368897 |
| NPSR1 | neuropeptide S receptor 1 | -0.0365867 |
| ERBIN | erbb2 interacting protein | -0.0359673 |
| TRERF1 | transcriptional regulating factor 1 | -0.0358335 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0357258 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0352433 |
| ENO1 | enolase 1, (alpha) | -0.0348961 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.034638 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0345762 |
| S100A10 | S100 calcium binding protein A10 | -0.0343557 |
| PLSCR1 | phospholipid scramblase 1 | -0.0343048 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.0341133 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0338348 |
| RIGI | RNA sensor RIG-I | -0.0337156 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0335079 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0333296 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0324071 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0318969 |
| MCL1 | myeloid cell leukemia 1 | -0.0317648 |
| SP100 | SP100 nuclear antigen | -0.0317353 |
| IRS2 | insulin receptor substrate 2 | -0.0315732 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0313531 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0312161 |
| VCL | vinculin | -0.0300832 |
| S100A6 | S100 calcium binding protein A6 | -0.0300526 |
| SMAD3 | SMAD family member 3 | -0.0300334 |
| RPL35A | ribosomal protein L35a | -0.030023 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0299193 |
| POTEF | POTE ankyrin domain family, member F | -0.0297375 |
| PTK2 | protein tyrosine kinase 2 | -0.0294996 |
| TNS4 | tensin 4 | -0.0292953 |
| SQSTM1 | sequestosome 1 | -0.0291534 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.028789 |
| CCNL1 | cyclin L1 | -0.0286539 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0285883 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.0282368 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0276798 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0268825 |
| PARD3 | par-3 family cell polarity regulator | -0.0267972 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0267023 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0266003 |
