Trametinib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trametinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trametinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.162328
COL1A1 collagen, type I, alpha 1 0.132766
PSD3 pleckstrin and Sec7 domain containing 3 0.111275
SOD2 superoxide dismutase 2, mitochondrial 0.102841
ACTG1 actin gamma 1 0.0840198
TIMP3 TIMP metallopeptidase inhibitor 3 0.0825948
EEF2 eukaryotic translation elongation factor 2 0.0662734
TPM4 tropomyosin 4 0.0651456
PLEC plectin 0.0598536
TGFBI transforming growth factor, beta-induced, 68kDa 0.0573644
DPYSL3 dihydropyrimidinase-like 3 0.0547285
TRIO trio Rho guanine nucleotide exchange factor 0.0523196
CALD1 caldesmon 1 0.0495648
FLNA filamin A, alpha 0.0482327
DST dystonin 0.044483
CFB complement factor B 0.042974
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0407639
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0395536
FN1 fibronectin 1 0.0392538
CSF1 colony stimulating factor 1 (macrophage) 0.0375783
COL5A1 collagen, type V, alpha 1 0.0349756
FBN1 fibrillin 1 0.0325109
RPL3 ribosomal protein L3 0.0319868
COL6A3 collagen, type VI, alpha 3 0.0318611
HDAC9 histone deacetylase 9 0.0313216
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0311457
LPP LIM domain containing preferred translocation partner in lipoma 0.0304975
FBXO32 F-box protein 32 0.0295689
NREP neuronal regeneration related protein 0.0284212
IGFBP3 insulin-like growth factor binding protein 3 0.0281536
MYOF myoferlin 0.0277129
TNS3 tensin 3 0.027138
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.0268611
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0267015
AHNAK AHNAK nucleoprotein 0.0255502
CAVIN1 caveolae associated protein 1 0.0253085
CALR calreticulin 0.0252119
COL3A1 collagen, type III, alpha 1 0.0239371
PARP14 poly (ADP-ribose) polymerase family, member 14 0.023409
DCLK1 doublecortin-like kinase 1 0.0228886
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0219382
SQSTM1 sequestosome 1 0.0219269
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.021758
ACTN4 actinin, alpha 4 0.0215958
ZFPM2 zinc finger protein, FOG family member 2 0.0213984
SAMD4A sterile alpha motif domain containing 4A 0.0213149
STC2 stanniocalcin 2 0.0211135
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0207849
PALLD palladin, cytoskeletal associated protein 0.020722
SULF1 sulfatase 1 0.0206818
JAG1 jagged 1 0.0206264
PRKCSH protein kinase C substrate 80K-H 0.020368
ENAH enabled homolog (Drosophila) 0.0202079
HLA-E major histocompatibility complex, class I, E 0.0201423
GBP2 guanylate binding protein 2, interferon-inducible 0.0198905
RIGI RNA sensor RIG-I 0.0197382
IFI44L interferon-induced protein 44-like 0.0196412
OPTN optineurin 0.0194242
FOXP1 forkhead box P1 0.0193991
RSAD2 radical S-adenosyl methionine domain containing 2 0.0190143
TNS1 tensin 1 0.0189462
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0188501
COL5A2 collagen, type V, alpha 2 0.0185903
CUX1 cut-like homeobox 1 0.0184556
TRAM2 translocation associated membrane protein 2 0.0184258
B2M beta-2-microglobulin 0.0180133
COL4A2 collagen, type IV, alpha 2 0.0179707
ZMIZ1 zinc finger, MIZ-type containing 1 0.0175451
HSPA8 heat shock 70kDa protein 8 0.0168101
CCDC80 coiled-coil domain containing 80 0.0166211
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0164537
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0164201
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0162738
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0161873
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0160307
COL4A1 collagen, type IV, alpha 1 0.015568
ZMAT4 zinc finger, matrin-type 4 0.0155432
AOPEP aminopeptidase O (putative) 0.0155244
PARP9 poly (ADP-ribose) polymerase family, member 9 0.0153471
ATXN1 ataxin 1 0.015194
LMNA lamin A/C 0.0150584
COL6A2 collagen, type VI, alpha 2 0.0148396
IFI6 interferon, alpha-inducible protein 6 0.014187
LIMCH1 LIM and calponin homology domains 1 0.014069
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0140146
CNOT12 CCR4-NOT transcription complex subunit 12 0.0138761
PRUNE2 prune homolog 2 (Drosophila) 0.0137481
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0137402
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0135988
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0135023
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0134067
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0133774
COL7A1 collagen, type VII, alpha 1 0.0133527
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.0133464
SLC12A8 solute carrier family 12, member 8 0.0132605
NCOR2 nuclear receptor corepressor 2 0.0132023
CNTN5 contactin 5 0.0130325
SAMD9 sterile alpha motif domain containing 9 0.0129364
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0129318
APP amyloid beta (A4) precursor protein 0.0128247

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.235068
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.203673
CDH13 cadherin 13 -0.145682
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.145362
MT2A metallothionein 2A -0.135956
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.133166
CD44 CD44 molecule (Indian blood group) -0.131465
STC1 stanniocalcin 1 -0.123485
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.117963
HMGA2 high mobility group AT-hook 2 -0.11231
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.109634
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0922228
PDE10A phosphodiesterase 10A -0.0762408
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0724593
NALF1 NALCN channel auxiliary factor 1 -0.0719102
ASPH aspartate beta-hydroxylase -0.0709118
GOLGA4 golgin A4 -0.0682169
TM4SF1 transmembrane 4 L six family member 1 -0.06419
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0626153
ATP13A3 ATPase type 13A3 -0.0614394
TMSB10 thymosin beta 10 -0.0611591
NDRG1 N-myc downstream regulated 1 -0.0605075
ELL2 elongation factor, RNA polymerase II, 2 -0.0583533
WWTR1 WW domain containing transcription regulator 1 -0.0571423
FTH1 ferritin, heavy polypeptide 1 -0.0568015
EFNA5 ephrin-A5 -0.0543763
IER3 immediate early response 3 -0.0522594
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0512554
F3 coagulation factor III (thromboplastin, tissue factor) -0.0504991
NAMPT nicotinamide phosphoribosyltransferase -0.0504618
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0500529
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0499806
LMAN1 lectin, mannose-binding, 1 -0.0488114
EGR1 early growth response 1 -0.0486144
DLG1 discs, large homolog 1 (Drosophila) -0.0486009
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0479437
ANTXR2 anthrax toxin receptor 2 -0.0470828
ECE1 endothelin converting enzyme 1 -0.0445473
DOCK5 dedicator of cytokinesis 5 -0.0427306
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0425089
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0424953
TIMP1 TIMP metallopeptidase inhibitor 1 -0.041469
CAMTA1 calmodulin binding transcription activator 1 -0.040317
IL6 interleukin 6 -0.0402634
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0400491
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0396517
CANX calnexin -0.0394861
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0391613
VEGFA vascular endothelial growth factor A -0.0390325
KMT2E lysine (K)-specific methyltransferase 2E -0.0387113
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0385669
RASA2 RAS p21 protein activator 2 -0.0383668
MTSS1 metastasis suppressor 1 -0.0380003
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0376541
TTC3 tetratricopeptide repeat domain 3 -0.0362196
COG5 component of oligomeric golgi complex 5 -0.0358792
HMGA1 high mobility group AT-hook 1 -0.0357752
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0353708
IL6ST interleukin 6 signal transducer -0.0352849
MRPS6 mitochondrial ribosomal protein S6 -0.035201
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.034958
KDM7A lysine (K)-specific demethylase 7A -0.0349132
RUNX1 runt-related transcription factor 1 -0.0347366
POSTN periostin, osteoblast specific factor -0.0340139
BBX bobby sox homolog (Drosophila) -0.0327358
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0325894
GOLGB1 golgin B1 -0.0322555
RTN4 reticulon 4 -0.0319687
CLMP CXADR-like membrane protein -0.0314872
FNDC3B fibronectin type III domain containing 3B -0.031183
TMEM165 transmembrane protein 165 -0.0308296
PRELID2 PRELI domain containing 2 -0.0307275
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0303931
RRBP1 ribosome binding protein 1 -0.0303642
PDIA3 protein disulfide isomerase family A, member 3 -0.0302408
OSMR oncostatin M receptor -0.0300435
FBXL13 F-box and leucine-rich repeat protein 13 -0.0300343
VIM vimentin -0.0298353
RAB2A RAB2A, member RAS oncogene family -0.0298318
JARID2 jumonji, AT rich interactive domain 2 -0.0291696
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0290398
SPAG9 sperm associated antigen 9 -0.0287537
RPS8 ribosomal protein S8 -0.0287247
SEC24A SEC24 family member A -0.0286867
SMYD3 SET and MYND domain containing 3 -0.0285709
ZBTB38 zinc finger and BTB domain containing 38 -0.0280656
RPL35A ribosomal protein L35a -0.028019
ALCAM activated leukocyte cell adhesion molecule -0.0275848
GRB10 growth factor receptor-bound protein 10 -0.0271637
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0270845
EVI5 ecotropic viral integration site 5 -0.0269684
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0269562
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0267981
DPYD dihydropyrimidine dehydrogenase -0.02672
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0267195
EXT1 exostosin glycosyltransferase 1 -0.0267009
NKTR natural killer cell triggering receptor -0.0265868
SEC24D SEC24 family member D -0.0265411
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.026507
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0262722